Anti-inflammatory effect of oligostilbenoids from Vitis heyneana in LPS-stimulated RAW 264.7 macrophages via suppressing the NF-ΚB activation
(2018) In Chemistry Central Journal 12(1).- Abstract
Background: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property. Results: Bioassay-guided fractionation of the EtOAc soluble fraction from the aerial part of Vitis heyneana resulted in the isolation of a series of oligostilbenoids as piceid (1), 2-r-viniferin (2), betulifol A (3), vitisinol C (4), (-)-trans-ε-viniferin (5), α-viniferin (6), shoreaketon (7), amurensin B (8), vitisinol B (9), and cis-vitisin B (10).... (More)
Background: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property. Results: Bioassay-guided fractionation of the EtOAc soluble fraction from the aerial part of Vitis heyneana resulted in the isolation of a series of oligostilbenoids as piceid (1), 2-r-viniferin (2), betulifol A (3), vitisinol C (4), (-)-trans-ε-viniferin (5), α-viniferin (6), shoreaketon (7), amurensin B (8), vitisinol B (9), and cis-vitisin B (10). Compound 5 showed the most potent inhibitory activities by suppressing LPS-induced COX-2 expression and PGE2 production. This compound exhibited significantly reduced LPS-induced nitric oxide (NO) release in a dose-dependent manner. These effects are accompanied with the inhibition of transcription factor NF-ΚB activation. Conclusion: The results suggested that trans-ε-viniferin exerts anti-inflammatory effects via suppression the NF-ΚB activation in RAW 264.7 cells. [Figure not available: see fulltext.]
(Less)
- author
- Ha, Do Thi ; Long, Phung Thanh ; Hien, Tran Thi LU ; Tuan, Dao Trong ; An, Nguyen Thi Thuy ; Khoi, Nguyen Minh ; Oanh, Ha and Hung, Tran Manh
- organization
- publishing date
- 2018-02-13
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- (-)-Trans-ε-viniferin, COX-2, NF-ΚB, NO, PGE2, Vitis heyneana
- in
- Chemistry Central Journal
- volume
- 12
- issue
- 1
- article number
- 14
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85042128726
- pmid:29442202
- ISSN
- 1752-153X
- DOI
- 10.1186/s13065-018-0386-5
- language
- English
- LU publication?
- yes
- id
- 231219a3-3959-483a-b9cf-636e662b57ab
- date added to LUP
- 2018-03-07 06:55:09
- date last changed
- 2024-04-29 05:07:39
@article{231219a3-3959-483a-b9cf-636e662b57ab, abstract = {{<p>Background: Vitis heyneana is widely distributed in the north of Vietnam, it has been used in Vietnamese traditional medicine as an agent for treatment of arthritis, bronchitis, carbuncles and inflammatory conditions, and menstrual irregularities. However, this plant has not been investigated in phytochemical constituents and biological effects, especially in the anti-inflammatory property. Results: Bioassay-guided fractionation of the EtOAc soluble fraction from the aerial part of Vitis heyneana resulted in the isolation of a series of oligostilbenoids as piceid (1), 2-r-viniferin (2), betulifol A (3), vitisinol C (4), (-)-trans-ε-viniferin (5), α-viniferin (6), shoreaketon (7), amurensin B (8), vitisinol B (9), and cis-vitisin B (10). Compound 5 showed the most potent inhibitory activities by suppressing LPS-induced COX-2 expression and PGE2 production. This compound exhibited significantly reduced LPS-induced nitric oxide (NO) release in a dose-dependent manner. These effects are accompanied with the inhibition of transcription factor NF-ΚB activation. Conclusion: The results suggested that trans-ε-viniferin exerts anti-inflammatory effects via suppression the NF-ΚB activation in RAW 264.7 cells. [Figure not available: see fulltext.]</p>}}, author = {{Ha, Do Thi and Long, Phung Thanh and Hien, Tran Thi and Tuan, Dao Trong and An, Nguyen Thi Thuy and Khoi, Nguyen Minh and Oanh, Ha and Hung, Tran Manh}}, issn = {{1752-153X}}, keywords = {{(-)-Trans-ε-viniferin; COX-2; NF-ΚB; NO; PGE2; Vitis heyneana}}, language = {{eng}}, month = {{02}}, number = {{1}}, publisher = {{BioMed Central (BMC)}}, series = {{Chemistry Central Journal}}, title = {{Anti-inflammatory effect of oligostilbenoids from Vitis heyneana in LPS-stimulated RAW 264.7 macrophages via suppressing the NF-ΚB activation}}, url = {{http://dx.doi.org/10.1186/s13065-018-0386-5}}, doi = {{10.1186/s13065-018-0386-5}}, volume = {{12}}, year = {{2018}}, }