Hyperbaric oxygen therapy as treatment of diabetic foot ulcers
(2012) In Diabetes/Metabolism Research & Reviews 28(Suppl. 1). p.78-84- Abstract
- Hyperbaric oxygen therapy (HBO) could be described as a short-term, high-dose oxygen inhalation and diffusion therapy, delivered systemically through airways and blood, achieved by having the patient breathing concentrated oxygen at a pressure higher than 1 absolute atmosphere. In clinical practice, monoplace or multiplace hyperbaric chambers are used to achieve this. Treatment is usually given as daily 90- to 120-min-long HBO sessions at pressures between 2.0 and 2.5 absolute atmosphere, aiming for 3040 treatment sessions. The use of HBO as treatment of diabetic foot ulcers has been founded on weak scientific ground, although the outcomes from previous studies are in concert with the conclusions from preclinical studies and supports the... (More)
- Hyperbaric oxygen therapy (HBO) could be described as a short-term, high-dose oxygen inhalation and diffusion therapy, delivered systemically through airways and blood, achieved by having the patient breathing concentrated oxygen at a pressure higher than 1 absolute atmosphere. In clinical practice, monoplace or multiplace hyperbaric chambers are used to achieve this. Treatment is usually given as daily 90- to 120-min-long HBO sessions at pressures between 2.0 and 2.5 absolute atmosphere, aiming for 3040 treatment sessions. The use of HBO as treatment of diabetic foot ulcers has been founded on weak scientific ground, although the outcomes from previous studies are in concert with the conclusions from preclinical studies and supports the theoretical framework of HBO reversing hypoxia-induced pathology. Two well-designed randomized double-blind trials have put HBO on firmer ground and may justify adjunctive HBO treatment to a selected group of patients with nonhealing diabetic foot ulcers. Some health economic studies suggest potential cost effectiveness, but these studies are limited by deficient primary clinical data and should be interpreted with caution. Several issues remain to be addressed, such as developing robust criteria to improve treatment protocols, determining which patients are likely to benefit, and when to start and stop treatment. Copyright (C) 2012 John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2348798
- author
- Löndahl, Magnus LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- diabetes, foot ulcer, hyperbaric oxygen, hyperbaric oxygen therapy, healing, review
- in
- Diabetes/Metabolism Research & Reviews
- volume
- 28
- issue
- Suppl. 1
- pages
- 78 - 84
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000299377700015
- pmid:22271728
- scopus:84856192847
- pmid:22271728
- ISSN
- 1520-7552
- DOI
- 10.1002/dmrr.2256
- language
- English
- LU publication?
- yes
- id
- f359102c-a54b-448b-b306-65d917d03aa8 (old id 2348798)
- date added to LUP
- 2016-04-01 10:24:21
- date last changed
- 2022-04-12 05:54:42
@article{f359102c-a54b-448b-b306-65d917d03aa8, abstract = {{Hyperbaric oxygen therapy (HBO) could be described as a short-term, high-dose oxygen inhalation and diffusion therapy, delivered systemically through airways and blood, achieved by having the patient breathing concentrated oxygen at a pressure higher than 1 absolute atmosphere. In clinical practice, monoplace or multiplace hyperbaric chambers are used to achieve this. Treatment is usually given as daily 90- to 120-min-long HBO sessions at pressures between 2.0 and 2.5 absolute atmosphere, aiming for 3040 treatment sessions. The use of HBO as treatment of diabetic foot ulcers has been founded on weak scientific ground, although the outcomes from previous studies are in concert with the conclusions from preclinical studies and supports the theoretical framework of HBO reversing hypoxia-induced pathology. Two well-designed randomized double-blind trials have put HBO on firmer ground and may justify adjunctive HBO treatment to a selected group of patients with nonhealing diabetic foot ulcers. Some health economic studies suggest potential cost effectiveness, but these studies are limited by deficient primary clinical data and should be interpreted with caution. Several issues remain to be addressed, such as developing robust criteria to improve treatment protocols, determining which patients are likely to benefit, and when to start and stop treatment. Copyright (C) 2012 John Wiley & Sons, Ltd.}}, author = {{Löndahl, Magnus}}, issn = {{1520-7552}}, keywords = {{diabetes; foot ulcer; hyperbaric oxygen; hyperbaric oxygen therapy; healing; review}}, language = {{eng}}, number = {{Suppl. 1}}, pages = {{78--84}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Diabetes/Metabolism Research & Reviews}}, title = {{Hyperbaric oxygen therapy as treatment of diabetic foot ulcers}}, url = {{http://dx.doi.org/10.1002/dmrr.2256}}, doi = {{10.1002/dmrr.2256}}, volume = {{28}}, year = {{2012}}, }