Rapid resolution of EPO-induced pure red cell aplasia after a course of immunoadsorption therapy using protein a columns
(2005) In American Journal of Kidney Diseases 45(6). p.97-99- Abstract
- Pure red cell aplasia (PRCA) is a rare, but important, complication of erythropoietin (EPO) replacement therapy in patients with renal disease. There is no consensus about the best way to treat this condition; however, recent reports indicated that immunosuppressive therapy is beneficial. We report a patient with EPO-induced PRCA treated with a regimen initially designed for antifactor VIII antibodies in patients with hemophilia. This regimen consists of immunoadsorption therapy using protein A columns, followed by oral prednisolone and single bolus infusions of intravenous immunoglobulin G and cyclophosphamide. Shortly after the course, a swift and rapid increase in reticulocyte count was evident; the patient became transfusion... (More)
- Pure red cell aplasia (PRCA) is a rare, but important, complication of erythropoietin (EPO) replacement therapy in patients with renal disease. There is no consensus about the best way to treat this condition; however, recent reports indicated that immunosuppressive therapy is beneficial. We report a patient with EPO-induced PRCA treated with a regimen initially designed for antifactor VIII antibodies in patients with hemophilia. This regimen consists of immunoadsorption therapy using protein A columns, followed by oral prednisolone and single bolus infusions of intravenous immunoglobulin G and cyclophosphamide. Shortly after the course, a swift and rapid increase in reticulocyte count was evident; the patient became transfusion independent and has remained so during 2 years of follow-up. By means of this report, we wish to encourage others to consider this option when first-line treatments fail. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/235962
- author
- Westerlund, P ; Kurkus, Jan LU and Segelmark, Mårten LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- immunoadsorption, protein A, erythropoietin (EPO), pure red cell aplasia
- in
- American Journal of Kidney Diseases
- volume
- 45
- issue
- 6
- pages
- 97 - 99
- publisher
- Elsevier
- external identifiers
-
- wos:000229857000028
- pmid:15957124
- scopus:20444401927
- ISSN
- 1523-6838
- DOI
- 10.1053/j.ajkd.2005.03.011
- language
- English
- LU publication?
- yes
- id
- 2459a960-a36a-45cf-9ab4-f77baf1989a3 (old id 235962)
- date added to LUP
- 2016-04-01 12:08:04
- date last changed
- 2022-01-26 23:19:34
@article{2459a960-a36a-45cf-9ab4-f77baf1989a3, abstract = {{Pure red cell aplasia (PRCA) is a rare, but important, complication of erythropoietin (EPO) replacement therapy in patients with renal disease. There is no consensus about the best way to treat this condition; however, recent reports indicated that immunosuppressive therapy is beneficial. We report a patient with EPO-induced PRCA treated with a regimen initially designed for antifactor VIII antibodies in patients with hemophilia. This regimen consists of immunoadsorption therapy using protein A columns, followed by oral prednisolone and single bolus infusions of intravenous immunoglobulin G and cyclophosphamide. Shortly after the course, a swift and rapid increase in reticulocyte count was evident; the patient became transfusion independent and has remained so during 2 years of follow-up. By means of this report, we wish to encourage others to consider this option when first-line treatments fail.}}, author = {{Westerlund, P and Kurkus, Jan and Segelmark, Mårten}}, issn = {{1523-6838}}, keywords = {{immunoadsorption; protein A; erythropoietin (EPO); pure red cell aplasia}}, language = {{eng}}, number = {{6}}, pages = {{97--99}}, publisher = {{Elsevier}}, series = {{American Journal of Kidney Diseases}}, title = {{Rapid resolution of EPO-induced pure red cell aplasia after a course of immunoadsorption therapy using protein a columns}}, url = {{http://dx.doi.org/10.1053/j.ajkd.2005.03.011}}, doi = {{10.1053/j.ajkd.2005.03.011}}, volume = {{45}}, year = {{2005}}, }