Spontaneous epileptic rats show changes in sleep architecture and hypothalamic pathology
(2005) In Epilepsia 46(6). p.934-938- Abstract
- Purpose: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats. Methods: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) activity and spontaneous reoccurring seizures (SRSs). Results: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and... (More)
- Purpose: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats. Methods: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) activity and spontaneous reoccurring seizures (SRSs). Results: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and neuronal cell loss in the dorsomedial hypothalamus, a region important for normal sleep regulation. Interestingly, epileptic rats showed disturbances in sleep architecture, with a high percentage of the seizures occurring during sleep. Conclusions: Therefore we conclude that a close association exists between epileptiform activity and alterations in sleep architecture that may be related to hypothalamic pathology. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/236217
- author
- Bastlund, JF ; Jennum, P ; Mohapel, Paul LU ; Penschuck, S and Watson, WP
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- seizures, radiotelemetry, electroencephalogram, neurodegeneration, sleep architecture
- in
- Epilepsia
- volume
- 46
- issue
- 6
- pages
- 934 - 938
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:15946334
- wos:000229802200014
- scopus:20544472035
- ISSN
- 0013-9580
- DOI
- 10.1111/j.1528-1167.2005.63204.x
- language
- English
- LU publication?
- yes
- id
- 7e4b86e6-3df1-4ecf-abdf-e3a1a9e3edcf (old id 236217)
- date added to LUP
- 2016-04-01 11:55:32
- date last changed
- 2022-02-10 23:31:14
@article{7e4b86e6-3df1-4ecf-abdf-e3a1a9e3edcf,
abstract = {{Purpose: The goal of the present study was to investigate the relationship between sleep, hypothalamic pathology, and seizures in spontaneous epileptic rats. Methods: Rats were implanted with radiotelemetry transmitters for measuring electrocorticogram (ECoG) and stimulation electrodes in the hippocampus. Epileptogenesis was triggered by 2 h of electical stimulation-induced self-sustained status epilepticus (SSSE). After SSSE, ECoGs were monitored over a 15-week period for the occurrence of interictal high-amplitude low-frequency (HALF) activity and spontaneous reoccurring seizures (SRSs). Results: Spontaneous epileptic rats showed clinical features of temporal lobe epilepsy (TLE), such as spontaneous seizures, interictal activity and neuronal cell loss in the dorsomedial hypothalamus, a region important for normal sleep regulation. Interestingly, epileptic rats showed disturbances in sleep architecture, with a high percentage of the seizures occurring during sleep. Conclusions: Therefore we conclude that a close association exists between epileptiform activity and alterations in sleep architecture that may be related to hypothalamic pathology.}},
author = {{Bastlund, JF and Jennum, P and Mohapel, Paul and Penschuck, S and Watson, WP}},
issn = {{0013-9580}},
keywords = {{seizures; radiotelemetry; electroencephalogram; neurodegeneration; sleep architecture}},
language = {{eng}},
number = {{6}},
pages = {{934--938}},
publisher = {{Wiley-Blackwell}},
series = {{Epilepsia}},
title = {{Spontaneous epileptic rats show changes in sleep architecture and hypothalamic pathology}},
url = {{http://dx.doi.org/10.1111/j.1528-1167.2005.63204.x}},
doi = {{10.1111/j.1528-1167.2005.63204.x}},
volume = {{46}},
year = {{2005}},
}