The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain
(1996) In Acta Physiologica Scandinavica 158(2). p.155-159- Abstract
The effect of the immunosuppressant FK506 on ischaemic neuronal damage was studied in a rat model of transient cerebral ischemia induced by occlusion of both common carotid arteries in combination with hypotension for 10 min. Neuronal damage was assessed morphologically after 4 days of recovery. Treatment with FK506, given at a dose of 2 mg kg-1 by intraperitoneal injections 30 min prior to ischemia and once daily during recovery, decreased neuronal damage by 52% in the hippocampal CA1 region and by 48% in the temporal cortex. The protection was not due to diminished body temperature or a marked reduction of ischaemia-induced synaptic overflow of glutamate. We propose that FK506 decreases neuronal damage either by inhibiting... (More)
The effect of the immunosuppressant FK506 on ischaemic neuronal damage was studied in a rat model of transient cerebral ischemia induced by occlusion of both common carotid arteries in combination with hypotension for 10 min. Neuronal damage was assessed morphologically after 4 days of recovery. Treatment with FK506, given at a dose of 2 mg kg-1 by intraperitoneal injections 30 min prior to ischemia and once daily during recovery, decreased neuronal damage by 52% in the hippocampal CA1 region and by 48% in the temporal cortex. The protection was not due to diminished body temperature or a marked reduction of ischaemia-induced synaptic overflow of glutamate. We propose that FK506 decreases neuronal damage either by inhibiting calcineurin-mediated events or by preserving mitochondrial function.
(Less)
- author
- Drake, M. ; Friberg, H. LU ; Boris-Möller, F. LU ; Sakata, K. and Wieloch, T. LU
- organization
- publishing date
- 1996-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- FK506, Glutamate, Immunophilin, Ischaemia, Mitochondria, Neuronal death
- in
- Acta Physiologica Scandinavica
- volume
- 158
- issue
- 2
- pages
- 5 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0029846173
- pmid:8899062
- ISSN
- 0001-6772
- DOI
- 10.1046/j.1365-201X.1996.535298000.x
- language
- English
- LU publication?
- yes
- id
- 238967d3-7091-4532-be68-23701eb0bcf5
- date added to LUP
- 2019-06-13 15:49:51
- date last changed
- 2024-02-15 12:03:01
@article{238967d3-7091-4532-be68-23701eb0bcf5,
abstract = {{<p>The effect of the immunosuppressant FK506 on ischaemic neuronal damage was studied in a rat model of transient cerebral ischemia induced by occlusion of both common carotid arteries in combination with hypotension for 10 min. Neuronal damage was assessed morphologically after 4 days of recovery. Treatment with FK506, given at a dose of 2 mg kg<sup>-1</sup> by intraperitoneal injections 30 min prior to ischemia and once daily during recovery, decreased neuronal damage by 52% in the hippocampal CA1 region and by 48% in the temporal cortex. The protection was not due to diminished body temperature or a marked reduction of ischaemia-induced synaptic overflow of glutamate. We propose that FK506 decreases neuronal damage either by inhibiting calcineurin-mediated events or by preserving mitochondrial function.</p>}},
author = {{Drake, M. and Friberg, H. and Boris-Möller, F. and Sakata, K. and Wieloch, T.}},
issn = {{0001-6772}},
keywords = {{FK506; Glutamate; Immunophilin; Ischaemia; Mitochondria; Neuronal death}},
language = {{eng}},
month = {{01}},
number = {{2}},
pages = {{155--159}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Physiologica Scandinavica}},
title = {{The immunosuppressant FK506 ameliorates ischaemic damage in the rat brain}},
url = {{http://dx.doi.org/10.1046/j.1365-201X.1996.535298000.x}},
doi = {{10.1046/j.1365-201X.1996.535298000.x}},
volume = {{158}},
year = {{1996}},
}