Gradient nanostructures for interfacing microfluidics and nanofluidics
(2002) In Applied Physics Letters 81(16). p.3058-3060- Abstract
It is difficult to introduce long genomic DNA molecules into nanometer scale fluidic channels directly from the macroscale world because of the steep entropic barrier caused by necessary stretching of the polymer. We present a very simple technique using optical lithography to fabricate continuous spatial gradient structures which smoothly narrow the cross section of a volume from the micron to the nanometer length scale, greatly reducing the local entropic barrier to nanochannel entry. This technique, diffraction gradient lithography, can be very valuable for the fabrication of micro/nano total analysis systems.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/24091303-d541-4093-aac4-ef6f050ff0a6
- author
- Cao, Han ; Tegenfeldt, Jonas O. LU ; Austin, Robert H. and Chou, Stephen Y.
- organization
- publishing date
- 2002-10-14
- type
- Contribution to journal
- publication status
- published
- in
- Applied Physics Letters
- volume
- 81
- issue
- 16
- pages
- 3 pages
- publisher
- American Institute of Physics (AIP)
- external identifiers
-
- scopus:79956006132
- ISSN
- 0003-6951
- DOI
- 10.1063/1.1515115
- language
- English
- LU publication?
- yes
- id
- 24091303-d541-4093-aac4-ef6f050ff0a6
- date added to LUP
- 2018-10-20 10:40:17
- date last changed
- 2022-03-17 18:25:31
@article{24091303-d541-4093-aac4-ef6f050ff0a6, abstract = {{<p>It is difficult to introduce long genomic DNA molecules into nanometer scale fluidic channels directly from the macroscale world because of the steep entropic barrier caused by necessary stretching of the polymer. We present a very simple technique using optical lithography to fabricate continuous spatial gradient structures which smoothly narrow the cross section of a volume from the micron to the nanometer length scale, greatly reducing the local entropic barrier to nanochannel entry. This technique, diffraction gradient lithography, can be very valuable for the fabrication of micro/nano total analysis systems.</p>}}, author = {{Cao, Han and Tegenfeldt, Jonas O. and Austin, Robert H. and Chou, Stephen Y.}}, issn = {{0003-6951}}, language = {{eng}}, month = {{10}}, number = {{16}}, pages = {{3058--3060}}, publisher = {{American Institute of Physics (AIP)}}, series = {{Applied Physics Letters}}, title = {{Gradient nanostructures for interfacing microfluidics and nanofluidics}}, url = {{http://dx.doi.org/10.1063/1.1515115}}, doi = {{10.1063/1.1515115}}, volume = {{81}}, year = {{2002}}, }