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Cerebrospinal fluid platelet-derived growth factor receptor-beta is negatively correlated with depressive symptom severity in suicide attempters

Bontidean, A. ; Lindqvist, D. LU ; Grudet, C. LU orcid ; Träskman-Bendz, L. LU ; Brundin, L. LU and Ventorp, F. LU (2025) In Journal of Affective Disorders Reports 20.
Abstract

Background: Depression and suicidal behavior have been linked to increased blood-brain barrier (BBB) permeability. Platelet-derived growth factor receptor beta (PDGFR-β) is widely expressed in pericytes and promotes BBB integrity. Here, we investigated cerebrospinal fluid (CSF) levels of PDGFR-β in suicide attempters and healthy controls and correlated PDGFR-β to depression symptom severity. Methods: We measured levels of PDGFR-β in CSF from recent suicide attempters using electrochemiluminescence immunoassays. PDGFR-β was correlated to CSF/serum albumin ratio (Qalb), an established BBB integrity biomarker, and symptom severity according to the Montgomery-Åsberg Depression Rating Scale (MADRS). Results: There was a significant negative... (More)

Background: Depression and suicidal behavior have been linked to increased blood-brain barrier (BBB) permeability. Platelet-derived growth factor receptor beta (PDGFR-β) is widely expressed in pericytes and promotes BBB integrity. Here, we investigated cerebrospinal fluid (CSF) levels of PDGFR-β in suicide attempters and healthy controls and correlated PDGFR-β to depression symptom severity. Methods: We measured levels of PDGFR-β in CSF from recent suicide attempters using electrochemiluminescence immunoassays. PDGFR-β was correlated to CSF/serum albumin ratio (Qalb), an established BBB integrity biomarker, and symptom severity according to the Montgomery-Åsberg Depression Rating Scale (MADRS). Results: There was a significant negative correlation between PDGFR-β and total MADRS score in suicide attempters (r=-0.47, p = 0.003, n = 38). PDGFR-β did not correlate significantly with Qalb (r = 0.179, p = 0.268, n = 40). Conclusions: Although PDGFR-β levels may not reflect BBB integrity, low CSF levels of this biomarker were associated with more severe depressive symptoms. We hypothesize that this may be due to mechanisms unrelated to BBB integrity including the effects of PDGFR-β on neurogenesis and cellular proliferation.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
BBB, depression, PDGFR-β, Suicidal behavior
in
Journal of Affective Disorders Reports
volume
20
article number
100906
publisher
Elsevier
external identifiers
  • scopus:105002312694
ISSN
2666-9153
DOI
10.1016/j.jadr.2025.100906
language
English
LU publication?
yes
id
242da29a-0730-4ca1-9b7a-5b629dda0412
date added to LUP
2025-08-19 13:03:00
date last changed
2025-08-19 13:04:11
@article{242da29a-0730-4ca1-9b7a-5b629dda0412,
  abstract     = {{<p>Background: Depression and suicidal behavior have been linked to increased blood-brain barrier (BBB) permeability. Platelet-derived growth factor receptor beta (PDGFR-β) is widely expressed in pericytes and promotes BBB integrity. Here, we investigated cerebrospinal fluid (CSF) levels of PDGFR-β in suicide attempters and healthy controls and correlated PDGFR-β to depression symptom severity. Methods: We measured levels of PDGFR-β in CSF from recent suicide attempters using electrochemiluminescence immunoassays. PDGFR-β was correlated to CSF/serum albumin ratio (Qalb), an established BBB integrity biomarker, and symptom severity according to the Montgomery-Åsberg Depression Rating Scale (MADRS). Results: There was a significant negative correlation between PDGFR-β and total MADRS score in suicide attempters (r=-0.47, p = 0.003, n = 38). PDGFR-β did not correlate significantly with Qalb (r = 0.179, p = 0.268, n = 40). Conclusions: Although PDGFR-β levels may not reflect BBB integrity, low CSF levels of this biomarker were associated with more severe depressive symptoms. We hypothesize that this may be due to mechanisms unrelated to BBB integrity including the effects of PDGFR-β on neurogenesis and cellular proliferation.</p>}},
  author       = {{Bontidean, A. and Lindqvist, D. and Grudet, C. and Träskman-Bendz, L. and Brundin, L. and Ventorp, F.}},
  issn         = {{2666-9153}},
  keywords     = {{BBB; depression; PDGFR-β; Suicidal behavior}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Affective Disorders Reports}},
  title        = {{Cerebrospinal fluid platelet-derived growth factor receptor-beta is negatively correlated with depressive symptom severity in suicide attempters}},
  url          = {{http://dx.doi.org/10.1016/j.jadr.2025.100906}},
  doi          = {{10.1016/j.jadr.2025.100906}},
  volume       = {{20}},
  year         = {{2025}},
}