Craniofacial dysmorphology in Swedish schizophrenia patients
(2005) In Acta Psychiatrica Scandinavica 111(3). p.202-207- Abstract
- Objective: To perform detailed assessments of craniofacial dysmorphology in individuals with schizophrenia and controls in Sweden, in order to further elucidate the neurodevelopmental origins of schizophrenia. Method: We performed detailed, anthropometric assessments of craniofacial dysmorphology in male patients with schizophrenia (n = 24), healthy controls (n = 16), and patients' siblings with schizophrenia (n = 2) in Sweden, while remaining as blind as possible to schizophrenia/control status. Results: Individuals with schizophrenia evidenced significantly more craniofacial dysmorphology than controls, especially in the ears and mouth. At a group level, there was a dose-response type relationship between total dysmorphology score and... (More)
- Objective: To perform detailed assessments of craniofacial dysmorphology in individuals with schizophrenia and controls in Sweden, in order to further elucidate the neurodevelopmental origins of schizophrenia. Method: We performed detailed, anthropometric assessments of craniofacial dysmorphology in male patients with schizophrenia (n = 24), healthy controls (n = 16), and patients' siblings with schizophrenia (n = 2) in Sweden, while remaining as blind as possible to schizophrenia/control status. Results: Individuals with schizophrenia evidenced significantly more craniofacial dysmorphology than controls, especially in the ears and mouth. At a group level, there was a dose-response type relationship between total dysmorphology score and patient/control status. Conclusion: The consistency of results across multiple studies supports the hypothesis that individuals with schizophrenia have increased rates of prenatal developmental disturbances. The presence of a dose-response type relationship between total dysmorphology score and patient/control status supports the importance of neurodevelopmental disturbance as a contributory cause of schizophrenia. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/253987
- author
- Kelly, B D ; Lane, A ; Agartz, I ; Henriksson, Karin LU and McNeil, Thomas LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- schizophrenia, aetiology, human development
- in
- Acta Psychiatrica Scandinavica
- volume
- 111
- issue
- 3
- pages
- 202 - 207
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000226899500006
- pmid:15701104
- scopus:14844291375
- pmid:15701104
- ISSN
- 1600-0447
- DOI
- 10.1111/j.1600-0447.2004.00473.x
- language
- English
- LU publication?
- yes
- id
- d129a152-0150-4bf6-be60-86591a150a75 (old id 253987)
- date added to LUP
- 2016-04-01 16:41:27
- date last changed
- 2022-01-28 21:28:31
@article{d129a152-0150-4bf6-be60-86591a150a75,
abstract = {{Objective: To perform detailed assessments of craniofacial dysmorphology in individuals with schizophrenia and controls in Sweden, in order to further elucidate the neurodevelopmental origins of schizophrenia. Method: We performed detailed, anthropometric assessments of craniofacial dysmorphology in male patients with schizophrenia (n = 24), healthy controls (n = 16), and patients' siblings with schizophrenia (n = 2) in Sweden, while remaining as blind as possible to schizophrenia/control status. Results: Individuals with schizophrenia evidenced significantly more craniofacial dysmorphology than controls, especially in the ears and mouth. At a group level, there was a dose-response type relationship between total dysmorphology score and patient/control status. Conclusion: The consistency of results across multiple studies supports the hypothesis that individuals with schizophrenia have increased rates of prenatal developmental disturbances. The presence of a dose-response type relationship between total dysmorphology score and patient/control status supports the importance of neurodevelopmental disturbance as a contributory cause of schizophrenia.}},
author = {{Kelly, B D and Lane, A and Agartz, I and Henriksson, Karin and McNeil, Thomas}},
issn = {{1600-0447}},
keywords = {{schizophrenia; aetiology; human development}},
language = {{eng}},
number = {{3}},
pages = {{202--207}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Psychiatrica Scandinavica}},
title = {{Craniofacial dysmorphology in Swedish schizophrenia patients}},
url = {{http://dx.doi.org/10.1111/j.1600-0447.2004.00473.x}},
doi = {{10.1111/j.1600-0447.2004.00473.x}},
volume = {{111}},
year = {{2005}},
}