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A genetic risk score for hypertension is associated with risk of thoracic aortic aneurysm

Tagetti, A. ; Bonafini, S. ; Ohlsson, T. LU ; Engström, G. LU ; Almgren, P. LU ; Minuz, P. ; Smith, G. LU ; Melander, O. LU orcid and Fava, C. LU (2019) In Journal of Human Hypertension 33(9). p.658-663
Abstract

A genetic risk score (GRS) based on 29 single nucleotide polymorpysms (SNPs) associated with high blood pressure (BP) was prospectively associated with development of hypertension, stroke and cardiovascular events. The aim of the present study was to evaluate the impact of this GRS on the incidence of aortic disease, including aortic dissection (AD), rupture or surgery of a thoracic (TAA) or abdominal (AAA) aortic aneurysm. More than 25,000 people from the Swedish Malmo Diet and Cancer Study had information on at least 24 SNPs and were followed up for a median ≥ 18 years. The number of BP elevating alleles of each SNPs, weighted by their effect size in the discovery studies, was summed into a BP-GRS. In Cox regression models, adjusted... (More)

A genetic risk score (GRS) based on 29 single nucleotide polymorpysms (SNPs) associated with high blood pressure (BP) was prospectively associated with development of hypertension, stroke and cardiovascular events. The aim of the present study was to evaluate the impact of this GRS on the incidence of aortic disease, including aortic dissection (AD), rupture or surgery of a thoracic (TAA) or abdominal (AAA) aortic aneurysm. More than 25,000 people from the Swedish Malmo Diet and Cancer Study had information on at least 24 SNPs and were followed up for a median ≥ 18 years. The number of BP elevating alleles of each SNPs, weighted by their effect size in the discovery studies, was summed into a BP-GRS. In Cox regression models, adjusted for traditional cardiovascular risk factors including hypertension, we found significant associations of the BP-GRS, prospectively, with incident TAA (hazard ratio (HR) 1.64 (95% confidence interval (CI) 1.081–2.475 comparing the third vs. the first tertile; p = 0.020) but not with either AAA or aortic dissection. Calibration, discrimination and reclassification analyses show modest improvement in prediction using the BP-GRS in addition to the model which used only traditional risk factors. A GRS for hypertension associates with TAA suggesting a link between genetic determinants of BP and aortic disease. The effect size is small but the addition of more SNPs to the GRS might improve its discriminatory capability.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Human Hypertension
volume
33
issue
9
pages
658 - 663
publisher
Nature Publishing Group
external identifiers
  • pmid:30659280
  • scopus:85060238949
ISSN
0950-9240
DOI
10.1038/s41371-018-0159-6
language
English
LU publication?
yes
id
253a6f05-79ef-4f45-8adf-4db6f85585a6
date added to LUP
2019-01-29 14:12:44
date last changed
2024-03-13 11:02:39
@article{253a6f05-79ef-4f45-8adf-4db6f85585a6,
  abstract     = {{<p>A genetic risk score (GRS) based on 29 single nucleotide polymorpysms (SNPs) associated with high blood pressure (BP) was prospectively associated with development of hypertension, stroke and cardiovascular events. The aim of the present study was to evaluate the impact of this GRS on the incidence of aortic disease, including aortic dissection (AD), rupture or surgery of a thoracic (TAA) or abdominal (AAA) aortic aneurysm. More than 25,000 people from the Swedish Malmo Diet and Cancer Study had information on at least 24 SNPs and were followed up for a median ≥ 18 years. The number of BP elevating alleles of each SNPs, weighted by their effect size in the discovery studies, was summed into a BP-GRS. In Cox regression models, adjusted for traditional cardiovascular risk factors including hypertension, we found significant associations of the BP-GRS, prospectively, with incident TAA (hazard ratio (HR) 1.64 (95% confidence interval (CI) 1.081–2.475 comparing the third vs. the first tertile; p = 0.020) but not with either AAA or aortic dissection. Calibration, discrimination and reclassification analyses show modest improvement in prediction using the BP-GRS in addition to the model which used only traditional risk factors. A GRS for hypertension associates with TAA suggesting a link between genetic determinants of BP and aortic disease. The effect size is small but the addition of more SNPs to the GRS might improve its discriminatory capability.</p>}},
  author       = {{Tagetti, A. and Bonafini, S. and Ohlsson, T. and Engström, G. and Almgren, P. and Minuz, P. and Smith, G. and Melander, O. and Fava, C.}},
  issn         = {{0950-9240}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{9}},
  pages        = {{658--663}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Journal of Human Hypertension}},
  title        = {{A genetic risk score for hypertension is associated with risk of thoracic aortic aneurysm}},
  url          = {{http://dx.doi.org/10.1038/s41371-018-0159-6}},
  doi          = {{10.1038/s41371-018-0159-6}},
  volume       = {{33}},
  year         = {{2019}},
}