Palladium(II), platinum(II) and gold(I) complexes containing chiral diphosphines of the Josiphos and Walphos families - Synthesis and evaluation as anticancer agents
(2012) In Polyhedron 36(1). p.97-103- Abstract
- A series of palladium(II) and platinum(II) complexes ([PdCl2(J003)] (1), [PdCl2(W001)] (2), [PtCl2(J003)] (3) and [PtCl2(W001)] (4), where J003 = the Josiphos ligand (R)-1-[(S)-2-diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine and W001 = the Walphos ligand (R)-1[(R)-2-(2'-diphenylphosphinyl) ferrocenyl]ethyldo(bis-3,5-trifluoromethylphenyl)phosphine), were prepared from the reaction of the diphosphine ligands with [PdCl2(NCMe)(2)] or [PtCl2(cod)] and characterised by multinuclear NMR spectroscopy, mass spectrometry and elemental analyses. Single crystal X-ray structures were used to confirm the proposed structures. Attempts to use the same ligands to prepare isoelectronic d(8) Au(III) analogues of the palladium and platinum... (More)
- A series of palladium(II) and platinum(II) complexes ([PdCl2(J003)] (1), [PdCl2(W001)] (2), [PtCl2(J003)] (3) and [PtCl2(W001)] (4), where J003 = the Josiphos ligand (R)-1-[(S)-2-diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine and W001 = the Walphos ligand (R)-1[(R)-2-(2'-diphenylphosphinyl) ferrocenyl]ethyldo(bis-3,5-trifluoromethylphenyl)phosphine), were prepared from the reaction of the diphosphine ligands with [PdCl2(NCMe)(2)] or [PtCl2(cod)] and characterised by multinuclear NMR spectroscopy, mass spectrometry and elemental analyses. Single crystal X-ray structures were used to confirm the proposed structures. Attempts to use the same ligands to prepare isoelectronic d(8) Au(III) analogues of the palladium and platinum complexes resulted in the reduction of Au(III) to Au(I) and isolation of the Au(I) complexes [AuCl(J003)] (5), [Au2Cl2(J003)] (6) and [Au2Cl2(W001)] (7). The cytotoxicity of the four chiral, bidentate ferrocenylphosphine palladium and platinum complexes was investigated against HeLa cells and were found to have low to moderate cytotoxicity. In general, the two Josiphos complexes showed better cytotoxicity compared to the Walphos complexes, irrespective of the metal used. (c) 2012 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2571038
- author
- Segapelo, Tebogo V. ; Lillywhite, Stacy ; Nordlander, Ebbe LU ; Haukka, Matti and Darkwa, James
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Chiral ligands, Diphosphine ligands, Palladium complexes, Platinum, complexes, Anticancer agents
- in
- Polyhedron
- volume
- 36
- issue
- 1
- pages
- 97 - 103
- publisher
- Elsevier
- external identifiers
-
- wos:000302983900014
- scopus:84858282568
- ISSN
- 0277-5387
- DOI
- 10.1016/j.poly.2012.01.027
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Chemical Physics (S) (011001060)
- id
- 43eef79e-f3f8-43c9-ad42-7ba39e12f7eb (old id 2571038)
- date added to LUP
- 2016-04-01 14:26:58
- date last changed
- 2022-01-28 00:40:53
@article{43eef79e-f3f8-43c9-ad42-7ba39e12f7eb, abstract = {{A series of palladium(II) and platinum(II) complexes ([PdCl2(J003)] (1), [PdCl2(W001)] (2), [PtCl2(J003)] (3) and [PtCl2(W001)] (4), where J003 = the Josiphos ligand (R)-1-[(S)-2-diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine and W001 = the Walphos ligand (R)-1[(R)-2-(2'-diphenylphosphinyl) ferrocenyl]ethyldo(bis-3,5-trifluoromethylphenyl)phosphine), were prepared from the reaction of the diphosphine ligands with [PdCl2(NCMe)(2)] or [PtCl2(cod)] and characterised by multinuclear NMR spectroscopy, mass spectrometry and elemental analyses. Single crystal X-ray structures were used to confirm the proposed structures. Attempts to use the same ligands to prepare isoelectronic d(8) Au(III) analogues of the palladium and platinum complexes resulted in the reduction of Au(III) to Au(I) and isolation of the Au(I) complexes [AuCl(J003)] (5), [Au2Cl2(J003)] (6) and [Au2Cl2(W001)] (7). The cytotoxicity of the four chiral, bidentate ferrocenylphosphine palladium and platinum complexes was investigated against HeLa cells and were found to have low to moderate cytotoxicity. In general, the two Josiphos complexes showed better cytotoxicity compared to the Walphos complexes, irrespective of the metal used. (c) 2012 Elsevier Ltd. All rights reserved.}}, author = {{Segapelo, Tebogo V. and Lillywhite, Stacy and Nordlander, Ebbe and Haukka, Matti and Darkwa, James}}, issn = {{0277-5387}}, keywords = {{Chiral ligands; Diphosphine ligands; Palladium complexes; Platinum; complexes; Anticancer agents}}, language = {{eng}}, number = {{1}}, pages = {{97--103}}, publisher = {{Elsevier}}, series = {{Polyhedron}}, title = {{Palladium(II), platinum(II) and gold(I) complexes containing chiral diphosphines of the Josiphos and Walphos families - Synthesis and evaluation as anticancer agents}}, url = {{http://dx.doi.org/10.1016/j.poly.2012.01.027}}, doi = {{10.1016/j.poly.2012.01.027}}, volume = {{36}}, year = {{2012}}, }