The Value of Induction Chemotherapy for Survival in Patients with Non-small Cell Lung Cancer Treated with Radiotherapy
(2012) In Anticancer research 32(4). p.1339-1346- Abstract
- Aim: The aim of the present study was to retrospectively investigate the impact of induction chemotherapy on treatment outcome in patients treated with curatively intended radiotherapy for non-small cell lung cancer (NSCLC). Patients and Methods: Patients with a diagnosed NSCLC that have been subjected to curatively intended irradiation (>= 50 Gy) and treated in an oncology department in Sweden during the years 1990-2000 were included in the study. Operated patients and patients having received concomitant chemotherapy were excluded. The included patients were localised by a manual search of all the oncology departments' medical records and radiation charts. Results: Patients treated with induction chemotherapy (n=79) had a... (More)
- Aim: The aim of the present study was to retrospectively investigate the impact of induction chemotherapy on treatment outcome in patients treated with curatively intended radiotherapy for non-small cell lung cancer (NSCLC). Patients and Methods: Patients with a diagnosed NSCLC that have been subjected to curatively intended irradiation (>= 50 Gy) and treated in an oncology department in Sweden during the years 1990-2000 were included in the study. Operated patients and patients having received concomitant chemotherapy were excluded. The included patients were localised by a manual search of all the oncology departments' medical records and radiation charts. Results: Patients treated with induction chemotherapy (n=79) had a significantly better overall survival compared with patients treated with radiotherapy alone (p=0.0097) in a univariate Cox regression analysis. A platinum/taxane combination produced the greatest survival benefit; hazard ratio=0.49 (95% confidence interval=0.31 to 0.75). Conclusion: We found that patients treated with induction chemotherapy in addition to radiotherapy for NSCLC have a better overall survival than patients treated with radiotherapy alone and that the best results are achieved using a platinum/taxane combination. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2587569
- author
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- NSCLC, lung cancer, radiotherapy, predictive value, age
- in
- Anticancer research
- volume
- 32
- issue
- 4
- pages
- 1339 - 1346
- publisher
- International Institute of Cancer Research
- external identifiers
-
- wos:000302492600028
- scopus:84859949728
- ISSN
- 1791-7530
- language
- English
- LU publication?
- yes
- id
- 7040a419-4451-4e21-8ae0-d1b2d04c4928 (old id 2587569)
- date added to LUP
- 2016-04-01 10:27:45
- date last changed
- 2025-04-04 13:56:09
@article{7040a419-4451-4e21-8ae0-d1b2d04c4928, abstract = {{Aim: The aim of the present study was to retrospectively investigate the impact of induction chemotherapy on treatment outcome in patients treated with curatively intended radiotherapy for non-small cell lung cancer (NSCLC). Patients and Methods: Patients with a diagnosed NSCLC that have been subjected to curatively intended irradiation (>= 50 Gy) and treated in an oncology department in Sweden during the years 1990-2000 were included in the study. Operated patients and patients having received concomitant chemotherapy were excluded. The included patients were localised by a manual search of all the oncology departments' medical records and radiation charts. Results: Patients treated with induction chemotherapy (n=79) had a significantly better overall survival compared with patients treated with radiotherapy alone (p=0.0097) in a univariate Cox regression analysis. A platinum/taxane combination produced the greatest survival benefit; hazard ratio=0.49 (95% confidence interval=0.31 to 0.75). Conclusion: We found that patients treated with induction chemotherapy in addition to radiotherapy for NSCLC have a better overall survival than patients treated with radiotherapy alone and that the best results are achieved using a platinum/taxane combination.}}, author = {{Holgersson, Georg and Sandelin, Martin and Hoye, Even and Bergstrom, Stefan and Henriksson, Roger and Ekman, Simon and Nyman, Jan and Helsing, Martin and Friesland, Signe and Brodin, Ola and Holgersson, Margareta and Lundstrom, Kristina Lamberg and Janson, Christer and Ekberg, Lars and Morth, Charlotte and Blystad, Thomas and Ewers, Sven-Börje and Loden, Britta and Bergqvist, Michael}}, issn = {{1791-7530}}, keywords = {{NSCLC; lung cancer; radiotherapy; predictive value; age}}, language = {{eng}}, number = {{4}}, pages = {{1339--1346}}, publisher = {{International Institute of Cancer Research}}, series = {{Anticancer research}}, title = {{The Value of Induction Chemotherapy for Survival in Patients with Non-small Cell Lung Cancer Treated with Radiotherapy}}, volume = {{32}}, year = {{2012}}, }