Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate
(2011) In Reproductive BioMedicine Online 23(2). p.187-195- Abstract
- Using data from a large prospective randomized controlled trial that evaluated the effect of recombinant LH (rLH) co-administration for ovarian stimulation, the present study assessed whether progesterone concentration on the day of human chorionic gonadotrophin (HCG) administration was associated with pregnancy outcome. Progesterone concentration was measured on stimulation day 1 and on the day of HCG administration in 475 patients who underwent IVF/intracytoplasmic sperm injection treatment following ovarian stimulation with gonadotrophin-releasing hormone (GnRH) agonist and recombinant FSH with or without rLH administration from day 6 of stimulation. There was no significant association between the late-follicular-phase progesterone... (More)
- Using data from a large prospective randomized controlled trial that evaluated the effect of recombinant LH (rLH) co-administration for ovarian stimulation, the present study assessed whether progesterone concentration on the day of human chorionic gonadotrophin (HCG) administration was associated with pregnancy outcome. Progesterone concentration was measured on stimulation day 1 and on the day of HCG administration in 475 patients who underwent IVF/intracytoplasmic sperm injection treatment following ovarian stimulation with gonadotrophin-releasing hormone (GnRH) agonist and recombinant FSH with or without rLH administration from day 6 of stimulation. There was no significant association between the late-follicular-phase progesterone concentration and the clinical pregnancy rate. However, progesterone concentration was strongly associated with the number of follicles and retrieved oocytes. Late-follicular-phase LH concentration also showed a significant positive association with progesterone concentration (P = 0.018). Administration of rLH during ovarian stimulation did not affect progesterone concentration. The present study does not support an association between progesterone concentration on the day of HCG administration and the probability of clinical pregnancy in women undergoing ovarian stimulation with GnRH agonists and gonadotrophins for assisted reproduction treatment. Instead, late-follicular-phase progesterone concentration appears to be governed by the number of preovulatory follicles and LH concentration. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2594759
- author
- Andersen, Claus Yding ; Bungum, Leif LU ; Andersen, Anders Nyboe and Humaidan, Peter
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ovarian stimulation, pregnancy outcome, progesterone elevation
- in
- Reproductive BioMedicine Online
- volume
- 23
- issue
- 2
- pages
- 187 - 195
- publisher
- Elsevier
- external identifiers
-
- wos:000303044500005
- scopus:79961173173
- pmid:21665546
- ISSN
- 1472-6491
- DOI
- 10.1016/j.rbmo.2011.04.003
- language
- English
- LU publication?
- yes
- id
- e88436bf-fa43-47ae-861f-08b0937c2545 (old id 2594759)
- date added to LUP
- 2016-04-01 10:52:42
- date last changed
- 2024-02-22 12:55:27
@article{e88436bf-fa43-47ae-861f-08b0937c2545,
abstract = {{Using data from a large prospective randomized controlled trial that evaluated the effect of recombinant LH (rLH) co-administration for ovarian stimulation, the present study assessed whether progesterone concentration on the day of human chorionic gonadotrophin (HCG) administration was associated with pregnancy outcome. Progesterone concentration was measured on stimulation day 1 and on the day of HCG administration in 475 patients who underwent IVF/intracytoplasmic sperm injection treatment following ovarian stimulation with gonadotrophin-releasing hormone (GnRH) agonist and recombinant FSH with or without rLH administration from day 6 of stimulation. There was no significant association between the late-follicular-phase progesterone concentration and the clinical pregnancy rate. However, progesterone concentration was strongly associated with the number of follicles and retrieved oocytes. Late-follicular-phase LH concentration also showed a significant positive association with progesterone concentration (P = 0.018). Administration of rLH during ovarian stimulation did not affect progesterone concentration. The present study does not support an association between progesterone concentration on the day of HCG administration and the probability of clinical pregnancy in women undergoing ovarian stimulation with GnRH agonists and gonadotrophins for assisted reproduction treatment. Instead, late-follicular-phase progesterone concentration appears to be governed by the number of preovulatory follicles and LH concentration. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.}},
author = {{Andersen, Claus Yding and Bungum, Leif and Andersen, Anders Nyboe and Humaidan, Peter}},
issn = {{1472-6491}},
keywords = {{ovarian stimulation; pregnancy outcome; progesterone elevation}},
language = {{eng}},
number = {{2}},
pages = {{187--195}},
publisher = {{Elsevier}},
series = {{Reproductive BioMedicine Online}},
title = {{Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate}},
url = {{http://dx.doi.org/10.1016/j.rbmo.2011.04.003}},
doi = {{10.1016/j.rbmo.2011.04.003}},
volume = {{23}},
year = {{2011}},
}