Patch testing with Finn Chambers could give false positive reactions in patients with contact allergy to aluminium
(2021) In Contact Dermatitis- Abstract
- Background
Earlier laboratory studies have shown that sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride trigger the release of aluminium (Al) from Finn Chambers (FC).
Objectives
To investigate whether aluminium realease from FC could influence the diagnostic outcome of patch testing with FC.
Method
A retrospective analysis of patch test results from 2010 to 2019 was performed. A two-sided Fisher's exact test was used to calculate any overrepresentation of contact allergy to Al among patients with positive reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride.
Results
A total of 5446 patients had been tested with FC... (More) - Background
Earlier laboratory studies have shown that sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride trigger the release of aluminium (Al) from Finn Chambers (FC).
Objectives
To investigate whether aluminium realease from FC could influence the diagnostic outcome of patch testing with FC.
Method
A retrospective analysis of patch test results from 2010 to 2019 was performed. A two-sided Fisher's exact test was used to calculate any overrepresentation of contact allergy to Al among patients with positive reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride.
Results
A total of 5446 patients had been tested with FC during the study period. There was a significant overrepresentation of contact allergy to Al among patients with positive reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride. Patients with a strong Al allergy had significantly higher amounts of concomitant reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride compared to patients with weak Al allergy. These results were not seen for patients tested with Finn Chambers AQUA.
Conclusion
In patients with contact allergy to Al, patch testing with Finn chambers could give false-positive reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/260330a6-9758-403d-8ab0-e7b95081d346
- author
- Rosholm Comstedt, Lisbeth LU ; Dahlin, Jakob LU ; Bruze, Magnus LU ; Hedberg, Yolanda ; Matura, Mihály and Svedman, Cecilia LU
- organization
- publishing date
- 2021-04-26
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aluminium corrosion, caine mix II, contact allergy to aluminium, Finn chambers, Myroxylon pereirae, palladium chloride, sodium tetrachloropalladate
- in
- Contact Dermatitis
- pages
- 8 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85108851988
- pmid:33896001
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.13870
- language
- English
- LU publication?
- yes
- id
- 260330a6-9758-403d-8ab0-e7b95081d346
- date added to LUP
- 2021-05-28 09:06:53
- date last changed
- 2022-11-08 02:25:47
@article{260330a6-9758-403d-8ab0-e7b95081d346,
abstract = {{Background<br/>Earlier laboratory studies have shown that sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride trigger the release of aluminium (Al) from Finn Chambers (FC).<br/><br/>Objectives<br/>To investigate whether aluminium realease from FC could influence the diagnostic outcome of patch testing with FC.<br/><br/>Method<br/>A retrospective analysis of patch test results from 2010 to 2019 was performed. A two-sided Fisher's exact test was used to calculate any overrepresentation of contact allergy to Al among patients with positive reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride.<br/><br/>Results<br/>A total of 5446 patients had been tested with FC during the study period. There was a significant overrepresentation of contact allergy to Al among patients with positive reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride. Patients with a strong Al allergy had significantly higher amounts of concomitant reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride compared to patients with weak Al allergy. These results were not seen for patients tested with Finn Chambers AQUA.<br/><br/>Conclusion<br/>In patients with contact allergy to Al, patch testing with Finn chambers could give false-positive reactions to sodium tetrachloropalladate, Myroxylon pereirae, caine mix II, and palladium chloride.}},
author = {{Rosholm Comstedt, Lisbeth and Dahlin, Jakob and Bruze, Magnus and Hedberg, Yolanda and Matura, Mihály and Svedman, Cecilia}},
issn = {{0105-1873}},
keywords = {{aluminium corrosion; caine mix II; contact allergy to aluminium; Finn chambers; Myroxylon pereirae; palladium chloride; sodium tetrachloropalladate}},
language = {{eng}},
month = {{04}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Patch testing with Finn Chambers could give false positive reactions in patients with contact allergy to aluminium}},
url = {{http://dx.doi.org/10.1111/cod.13870}},
doi = {{10.1111/cod.13870}},
year = {{2021}},
}