Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia
(2004) In Neurobiology of Disease 17(2). p.219-236- Abstract
- We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (L-DOPA)-induced dyskinesia and Parkinson disease (PD). 6-Hydroxydopamine (6-OHDA)-lesioned rats were treated with L-DOPA or physiological saline for 22 days and repeatedly tested for antiakinetic response to L-DOPA and the development of abnormal involuntary movements (AIMs). In a comparison of rats that developed a dyskinetic motor response to rats that did not, we found striking differences in gene expression patterns. In rats that developed dyskinesia, GABA neurons had an increased transcriptional activity, and genes involved in Ca2+ homeostasis, in Ca2+-dependent signaling, and in structural and synaptic plasticity were... (More)
- We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (L-DOPA)-induced dyskinesia and Parkinson disease (PD). 6-Hydroxydopamine (6-OHDA)-lesioned rats were treated with L-DOPA or physiological saline for 22 days and repeatedly tested for antiakinetic response to L-DOPA and the development of abnormal involuntary movements (AIMs). In a comparison of rats that developed a dyskinetic motor response to rats that did not, we found striking differences in gene expression patterns. In rats that developed dyskinesia, GABA neurons had an increased transcriptional activity, and genes involved in Ca2+ homeostasis, in Ca2+-dependent signaling, and in structural and synaptic plasticity were upregulated. The gene expression patterns implied that the dyskinetic striatum had increased transcriptional, as well as synaptic activity, and decreased capacity for energy production. Some basic maintenance chores such as ribosome protein biosynthesis were downregulated, possibly a response to expended of ATP levels. (C) 2004 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/262322
- author
- Konradi, C ; Westin, Jenny LU ; Carta, Manolo LU ; Eaton, ME ; Kuter, Katarzyna LU ; Dekundy, A ; Lundblad, Martin LU and Cenci Nilsson, Angela LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- calcium, striatum, microarrays, gene, 6-hydroxydopamine, Parkinson's disease, L-DOPA, dyskinesia, GABA, ATPases, ribosomes
- in
- Neurobiology of Disease
- volume
- 17
- issue
- 2
- pages
- 219 - 236
- publisher
- Elsevier
- external identifiers
-
- pmid:15474360
- wos:000224757500011
- scopus:5144228175
- ISSN
- 0969-9961
- DOI
- 10.1016/j.nbd.2004.07.005
- language
- English
- LU publication?
- yes
- id
- 926387a3-19fe-44a2-bda6-a845b7c8973b (old id 262322)
- date added to LUP
- 2016-04-01 11:57:05
- date last changed
- 2022-04-05 07:28:30
@article{926387a3-19fe-44a2-bda6-a845b7c8973b, abstract = {{We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (L-DOPA)-induced dyskinesia and Parkinson disease (PD). 6-Hydroxydopamine (6-OHDA)-lesioned rats were treated with L-DOPA or physiological saline for 22 days and repeatedly tested for antiakinetic response to L-DOPA and the development of abnormal involuntary movements (AIMs). In a comparison of rats that developed a dyskinetic motor response to rats that did not, we found striking differences in gene expression patterns. In rats that developed dyskinesia, GABA neurons had an increased transcriptional activity, and genes involved in Ca2+ homeostasis, in Ca2+-dependent signaling, and in structural and synaptic plasticity were upregulated. The gene expression patterns implied that the dyskinetic striatum had increased transcriptional, as well as synaptic activity, and decreased capacity for energy production. Some basic maintenance chores such as ribosome protein biosynthesis were downregulated, possibly a response to expended of ATP levels. (C) 2004 Elsevier Inc. All rights reserved.}}, author = {{Konradi, C and Westin, Jenny and Carta, Manolo and Eaton, ME and Kuter, Katarzyna and Dekundy, A and Lundblad, Martin and Cenci Nilsson, Angela}}, issn = {{0969-9961}}, keywords = {{calcium; striatum; microarrays; gene; 6-hydroxydopamine; Parkinson's disease; L-DOPA; dyskinesia; GABA; ATPases; ribosomes}}, language = {{eng}}, number = {{2}}, pages = {{219--236}}, publisher = {{Elsevier}}, series = {{Neurobiology of Disease}}, title = {{Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia}}, url = {{http://dx.doi.org/10.1016/j.nbd.2004.07.005}}, doi = {{10.1016/j.nbd.2004.07.005}}, volume = {{17}}, year = {{2004}}, }