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Spotlight on innovation : key insights from the extracellular vesicle cluster meeting at the European Innovation Council

Adamo, Giorgia ; Amarantos, Ioannis ; Arzimanoglou, Iordanis ; Bergese, Paolo ; Bongiovanni, Antonella ; Bussolati, Benedetta ; Cauda, Valentina ; Chiari, Marcella ; Garinis, George A. and Giebel, Bernd , et al. (2025) In Cytotherapy
Abstract

The field of extracellular vesicles (EVs) is rapidly advancing, offering promising applications in diagnostics, therapeutics, and drug delivery. However, the translation of EV-based technologies to the clinic faces significant challenges related to heterogeneity, scalable biomanufacturing, and regulatory compliance. To address these issues, the European Innovation Council (EIC), in collaboration with the Horizon2020-funded BOW project, organized the “Extracellular Vesicle EIC Cluster Meeting,” bringing together researchers, startups, and regulatory stakeholders across Europe. Discussions focused on overcoming bottlenecks in EV production, standardization, and clinical readiness. Key outcomes included the need for application-specific... (More)

The field of extracellular vesicles (EVs) is rapidly advancing, offering promising applications in diagnostics, therapeutics, and drug delivery. However, the translation of EV-based technologies to the clinic faces significant challenges related to heterogeneity, scalable biomanufacturing, and regulatory compliance. To address these issues, the European Innovation Council (EIC), in collaboration with the Horizon2020-funded BOW project, organized the “Extracellular Vesicle EIC Cluster Meeting,” bringing together researchers, startups, and regulatory stakeholders across Europe. Discussions focused on overcoming bottlenecks in EV production, standardization, and clinical readiness. Key outcomes included the need for application-specific benchmarks, robust manufacturing pipelines, and regulatory frameworks tailored to EVs. The event emphasized the importance of interdisciplinary collaboration, coopetition, and continued EU funding to drive innovation and strengthen Europe's leadership in the EV field.

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publishing date
type
Contribution to journal
publication status
in press
subject
keywords
biomanufacturing, clinical translation, extracellular vesicles, regulatory landscape, standardization
in
Cytotherapy
article number
101976
publisher
Taylor & Francis
external identifiers
  • pmid:41137847
  • scopus:105020089379
ISSN
1465-3249
DOI
10.1016/j.jcyt.2025.08.008
language
English
LU publication?
no
additional info
Publisher Copyright: © 2025 International Society for Cell & Gene Therapy
id
270505db-8b2b-486e-9700-f252cd83d0db
date added to LUP
2025-12-01 13:45:52
date last changed
2025-12-15 15:17:23
@article{270505db-8b2b-486e-9700-f252cd83d0db,
  abstract     = {{<p>The field of extracellular vesicles (EVs) is rapidly advancing, offering promising applications in diagnostics, therapeutics, and drug delivery. However, the translation of EV-based technologies to the clinic faces significant challenges related to heterogeneity, scalable biomanufacturing, and regulatory compliance. To address these issues, the European Innovation Council (EIC), in collaboration with the Horizon2020-funded BOW project, organized the “Extracellular Vesicle EIC Cluster Meeting,” bringing together researchers, startups, and regulatory stakeholders across Europe. Discussions focused on overcoming bottlenecks in EV production, standardization, and clinical readiness. Key outcomes included the need for application-specific benchmarks, robust manufacturing pipelines, and regulatory frameworks tailored to EVs. The event emphasized the importance of interdisciplinary collaboration, coopetition, and continued EU funding to drive innovation and strengthen Europe's leadership in the EV field.</p>}},
  author       = {{Adamo, Giorgia and Amarantos, Ioannis and Arzimanoglou, Iordanis and Bergese, Paolo and Bongiovanni, Antonella and Bussolati, Benedetta and Cauda, Valentina and Chiari, Marcella and Garinis, George A. and Giebel, Bernd and Guazzi, Paolo and Jurga, Marcin and Neri, Christian and Ohlsson, Pelle and Rohde, Eva and Sales, Goreti and Trapani, Irene and Vader, Pieter and Vainio, Seppo and Wauben, Marca H.M. and Yáñez-Mó, María and Zarovni, Natasa}},
  issn         = {{1465-3249}},
  keywords     = {{biomanufacturing; clinical translation; extracellular vesicles; regulatory landscape; standardization}},
  language     = {{eng}},
  month        = {{08}},
  publisher    = {{Taylor & Francis}},
  series       = {{Cytotherapy}},
  title        = {{Spotlight on innovation : key insights from the extracellular vesicle cluster meeting at the European Innovation Council}},
  url          = {{http://dx.doi.org/10.1016/j.jcyt.2025.08.008}},
  doi          = {{10.1016/j.jcyt.2025.08.008}},
  year         = {{2025}},
}