Reactional changes in short-term levonorgestrel-releasing intrauterine system (lng-ius) use
(2019) In Revista da Associacao Medica Brasileira 65(6). p.857-863- Abstract
OBJECTIVE: To evaluate endocervical and vaginal environment changes in women using a levonorgestrel-releasing intrauterine system (LNG-IUS).
METHODS: A quasi-experimental study included sixty women who had an LNG-IUS inserted in the Family Planning Clinic of UNICAMP between April and November of 2016. Women in reproductive age, non-pregnant, without the use of antibiotics and contraceptives seeking for LNG-IUS insertion were selected for this study. All women were evaluated with regard to vaginal and endocervical pH, vaginal and endocervical Gram-stained bacterioscopy, and Pap-smear before and two months after LNG-IUS insertion. Clinical aspects such as cervical mucus, vaginal discharge, and cervical ectopy were also... (More)
OBJECTIVE: To evaluate endocervical and vaginal environment changes in women using a levonorgestrel-releasing intrauterine system (LNG-IUS).
METHODS: A quasi-experimental study included sixty women who had an LNG-IUS inserted in the Family Planning Clinic of UNICAMP between April and November of 2016. Women in reproductive age, non-pregnant, without the use of antibiotics and contraceptives seeking for LNG-IUS insertion were selected for this study. All women were evaluated with regard to vaginal and endocervical pH, vaginal and endocervical Gram-stained bacterioscopy, and Pap-smear before and two months after LNG-IUS insertion. Clinical aspects such as cervical mucus, vaginal discharge, and cervical ectopy were also observed.
RESULTS: After LNG-IUS insertion, there was an increase in the following parameters: endocervical pH>4.5 (p=0.02), endocervical neutrophil amount (p<0.0001), vaginal cytolysis (p=0.04). There was a decrease in vaginal discharge (p=0.01). No statistically significant changes were found in vaginal pH, neutrophils amount in the vaginal mucosa, vaginal discharge appearance, vaginal candidiasis, bacterial vaginosis, vaginal coccobacillary microbiota, cervical mucus appearance, or cervical ectopy size.
CONCLUSIONS: Short-term LNG-IUS use did not increase vulvovaginal candidiasis or bacterial vaginosis, and led to diminished vaginal discharge. Notwithstanding, this device promoted reactional changes in the vaginal and endocervical environment, without modification on cervical ectopy size.
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- author
- Giraldo, Paulo César ; Souza, Thais Coelho de ; Henrique, Guilherme Lindman ; Monteiro, Ilza ; Amaral, Rose ; Machado, Rogério Bonassi ; Discacciati, Michelle Garcia and Sanches, José Marcos LU
- publishing date
- 2019-07-22
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adolescent, Adult, Cervix Uteri/drug effects, Contraceptive Agents, Female/adverse effects, Endometrium/drug effects, Female, Humans, Intrauterine Devices, Medicated/adverse effects, Levonorgestrel/adverse effects, Middle Aged, Papanicolaou Test, Statistics, Nonparametric, Time Factors, Vagina/chemistry, Vaginal Smears, Young Adult
- in
- Revista da Associacao Medica Brasileira
- volume
- 65
- issue
- 6
- pages
- 7 pages
- publisher
- Associacao Medica Brasileira
- external identifiers
-
- pmid:31340317
- scopus:85070531044
- ISSN
- 0104-4230
- DOI
- 10.1590/1806-9282.65.6.857
- language
- English
- LU publication?
- no
- id
- 2719343a-c484-490d-b45a-29003bcfca40
- date added to LUP
- 2021-03-31 14:07:20
- date last changed
- 2024-06-01 08:21:25
@article{2719343a-c484-490d-b45a-29003bcfca40,
abstract = {{<p>OBJECTIVE: To evaluate endocervical and vaginal environment changes in women using a levonorgestrel-releasing intrauterine system (LNG-IUS).</p><p>METHODS: A quasi-experimental study included sixty women who had an LNG-IUS inserted in the Family Planning Clinic of UNICAMP between April and November of 2016. Women in reproductive age, non-pregnant, without the use of antibiotics and contraceptives seeking for LNG-IUS insertion were selected for this study. All women were evaluated with regard to vaginal and endocervical pH, vaginal and endocervical Gram-stained bacterioscopy, and Pap-smear before and two months after LNG-IUS insertion. Clinical aspects such as cervical mucus, vaginal discharge, and cervical ectopy were also observed.</p><p>RESULTS: After LNG-IUS insertion, there was an increase in the following parameters: endocervical pH>4.5 (p=0.02), endocervical neutrophil amount (p<0.0001), vaginal cytolysis (p=0.04). There was a decrease in vaginal discharge (p=0.01). No statistically significant changes were found in vaginal pH, neutrophils amount in the vaginal mucosa, vaginal discharge appearance, vaginal candidiasis, bacterial vaginosis, vaginal coccobacillary microbiota, cervical mucus appearance, or cervical ectopy size.</p><p>CONCLUSIONS: Short-term LNG-IUS use did not increase vulvovaginal candidiasis or bacterial vaginosis, and led to diminished vaginal discharge. Notwithstanding, this device promoted reactional changes in the vaginal and endocervical environment, without modification on cervical ectopy size.</p>}},
author = {{Giraldo, Paulo César and Souza, Thais Coelho de and Henrique, Guilherme Lindman and Monteiro, Ilza and Amaral, Rose and Machado, Rogério Bonassi and Discacciati, Michelle Garcia and Sanches, José Marcos}},
issn = {{0104-4230}},
keywords = {{Adolescent; Adult; Cervix Uteri/drug effects; Contraceptive Agents, Female/adverse effects; Endometrium/drug effects; Female; Humans; Intrauterine Devices, Medicated/adverse effects; Levonorgestrel/adverse effects; Middle Aged; Papanicolaou Test; Statistics, Nonparametric; Time Factors; Vagina/chemistry; Vaginal Smears; Young Adult}},
language = {{eng}},
month = {{07}},
number = {{6}},
pages = {{857--863}},
publisher = {{Associacao Medica Brasileira}},
series = {{Revista da Associacao Medica Brasileira}},
title = {{Reactional changes in short-term levonorgestrel-releasing intrauterine system (lng-ius) use}},
url = {{http://dx.doi.org/10.1590/1806-9282.65.6.857}},
doi = {{10.1590/1806-9282.65.6.857}},
volume = {{65}},
year = {{2019}},
}