Neocartilage after artificial cartilage repair in the rabbit : Histology and proteoglycan fragments in joint fluid
(1993) In Journal of Biomedical Materials Research 27(7). p.949-954- Abstract
Repair of full-thickness cartilage defects of the rabbit medial femoral condyle with artificial plugs and periosteal grafts was followed for 1 year. The morphological characteristics of the neocartilage after repair and the concentration of proteoglycan fragments in the joint fluid (CPFF) were evaluated. The CPFF showed only a weak correlation to the histological score of the neocartilage. Normal cartilage and subchondral bone did not develop with any of the repair alternatives. With a Dacron plug, neocartilage formation appeared earlier than with natural repair and was better than with periosteal grafting. We conclude that Dacron plugs could serve as a scaffold for neocartilage formation. The CPFF reflected surgical trauma and late... (More)
Repair of full-thickness cartilage defects of the rabbit medial femoral condyle with artificial plugs and periosteal grafts was followed for 1 year. The morphological characteristics of the neocartilage after repair and the concentration of proteoglycan fragments in the joint fluid (CPFF) were evaluated. The CPFF showed only a weak correlation to the histological score of the neocartilage. Normal cartilage and subchondral bone did not develop with any of the repair alternatives. With a Dacron plug, neocartilage formation appeared earlier than with natural repair and was better than with periosteal grafting. We conclude that Dacron plugs could serve as a scaffold for neocartilage formation. The CPFF reflected surgical trauma and late degeneration of neocartilage but did not indicate minor differences in quality between cartilage repair techniques, probably because of the limited size of the grafted defect.
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- author
- Messner, K. ; Lohmander, L. S. LU and Gillquist, J.
- organization
- publishing date
- 1993-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Biomedical Materials Research
- volume
- 27
- issue
- 7
- pages
- 6 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:8360221
- scopus:0027627382
- ISSN
- 0021-9304
- language
- English
- LU publication?
- yes
- id
- 2844671f-986e-4492-b9ce-9bbeba5ba009
- date added to LUP
- 2016-05-04 23:40:40
- date last changed
- 2024-01-04 02:50:00
@article{2844671f-986e-4492-b9ce-9bbeba5ba009, abstract = {{<p>Repair of full-thickness cartilage defects of the rabbit medial femoral condyle with artificial plugs and periosteal grafts was followed for 1 year. The morphological characteristics of the neocartilage after repair and the concentration of proteoglycan fragments in the joint fluid (CPFF) were evaluated. The CPFF showed only a weak correlation to the histological score of the neocartilage. Normal cartilage and subchondral bone did not develop with any of the repair alternatives. With a Dacron plug, neocartilage formation appeared earlier than with natural repair and was better than with periosteal grafting. We conclude that Dacron plugs could serve as a scaffold for neocartilage formation. The CPFF reflected surgical trauma and late degeneration of neocartilage but did not indicate minor differences in quality between cartilage repair techniques, probably because of the limited size of the grafted defect.</p>}}, author = {{Messner, K. and Lohmander, L. S. and Gillquist, J.}}, issn = {{0021-9304}}, language = {{eng}}, number = {{7}}, pages = {{949--954}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Journal of Biomedical Materials Research}}, title = {{Neocartilage after artificial cartilage repair in the rabbit : Histology and proteoglycan fragments in joint fluid}}, volume = {{27}}, year = {{1993}}, }