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RIFM fragrance ingredient safety assessment, p-α,α-trimethylbenzyl alcohol, CAS Registry Number 1197-01-9

Api, A. M. ; Belsito, D. ; Biserta, S. ; Botelho, D. ; Bruze, M. LU ; Burton, G. A. ; Buschmann, J. ; Cancellieri, M. A. ; Dagli, M. L. and Date, M. , et al. (2020) In Food and Chemical Toxicology 141.
Abstract

The existing information supports the use of this material as described in this safety assessment. p-α,α-Trimethylbenzyl alcohol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that p-α,α-trimethylbenzyl alcohol is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicological concern (TTC) for a Cramer Class I material, and the exposure to p-α,α-trimethylbenzyl alcohol is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the dermal... (More)

The existing information supports the use of this material as described in this safety assessment. p-α,α-Trimethylbenzyl alcohol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that p-α,α-trimethylbenzyl alcohol is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicological concern (TTC) for a Cramer Class I material, and the exposure to p-α,α-trimethylbenzyl alcohol is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for non-reactive materials (900 μg/cm2); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; p-α,α- trimethylbenzyl alcohol is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; p-α,α-trimethylbenzyl alcohol was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Food and Chemical Toxicology
volume
141
article number
111427
publisher
Elsevier
external identifiers
  • scopus:85085326095
  • pmid:32439589
ISSN
0278-6915
DOI
10.1016/j.fct.2020.111427
language
English
LU publication?
no
id
2918da9b-e512-4a25-b868-1365e775935d
date added to LUP
2020-06-18 12:40:17
date last changed
2024-04-03 08:47:47
@article{2918da9b-e512-4a25-b868-1365e775935d,
  abstract     = {{<p>The existing information supports the use of this material as described in this safety assessment. p-α,α-Trimethylbenzyl alcohol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that p-α,α-trimethylbenzyl alcohol is not genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicological concern (TTC) for a Cramer Class I material, and the exposure to p-α,α-trimethylbenzyl alcohol is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for non-reactive materials (900 μg/cm2); exposure is below the DST. The phototoxicity/photoallergenicity endpoints were evaluated based on ultraviolet (UV) spectra; p-α,α- trimethylbenzyl alcohol is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated; p-α,α-trimethylbenzyl alcohol was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are &lt;1.</p>}},
  author       = {{Api, A. M. and Belsito, D. and Biserta, S. and Botelho, D. and Bruze, M. and Burton, G. A. and Buschmann, J. and Cancellieri, M. A. and Dagli, M. L. and Date, M. and Dekant, W. and Deodhar, C. and Fryer, A. D. and Gadhia, S. and Jones, L. and Joshi, K. and Lapczynski, A. and Lavelle, M. and Liebler, D. C. and Na, M. and O'Brien, D. and Patel, A. and Penning, T. M. and Ritacco, G. and Rodriguez-Ropero, F. and Romine, J. and Sadekar, N. and Salvito, D. and Schultz, T. W. and Siddiqi, F. and Sipes, I. G. and Sullivan, G. and Thakkar, Y. and Tokura, Y. and Tsang, S.}},
  issn         = {{0278-6915}},
  language     = {{eng}},
  month        = {{12}},
  publisher    = {{Elsevier}},
  series       = {{Food and Chemical Toxicology}},
  title        = {{RIFM fragrance ingredient safety assessment, p-α,α-trimethylbenzyl alcohol, CAS Registry Number 1197-01-9}},
  url          = {{http://dx.doi.org/10.1016/j.fct.2020.111427}},
  doi          = {{10.1016/j.fct.2020.111427}},
  volume       = {{141}},
  year         = {{2020}},
}