The fragrance hand immersion study - an experimental model simulating real-life exposure for allergic contact dermatitis on the hands
(2003) In Contact Dermatitis 48(6). p.324-330- Abstract
- Recently, we showed that 10.2% of consecutively patch-tested hand eczema patients had a positive patch test to a selection of fragrances containing fragrances relevant to hand exposure. In this study, we used repeated skin exposure to a patch test-positive fragrance allergen in patients previously diagnosed with hand eczema to explore whether immersion of fingers in a solution with or without the patch-test-positive fragrance allergen would cause or exacerbate hand eczema on the exposed finger. The study was double blinded and randomized. All participants had a positive patch test to either hydroxycitronellal or Lyral(R) (hydroxyisohexyl 3-cyclohexene carboxaldehyde). Each participant immersed a finger from each hand, once a day, in a... (More)
- Recently, we showed that 10.2% of consecutively patch-tested hand eczema patients had a positive patch test to a selection of fragrances containing fragrances relevant to hand exposure. In this study, we used repeated skin exposure to a patch test-positive fragrance allergen in patients previously diagnosed with hand eczema to explore whether immersion of fingers in a solution with or without the patch-test-positive fragrance allergen would cause or exacerbate hand eczema on the exposed finger. The study was double blinded and randomized. All participants had a positive patch test to either hydroxycitronellal or Lyral(R) (hydroxyisohexyl 3-cyclohexene carboxaldehyde). Each participant immersed a finger from each hand, once a day, in a solution containing the fragrance allergen or placebo. During the first 2 weeks, the concentration of fragrance allergen in the solution was low (approximately 10 p.p.m.), whilst during the following 2 weeks, the concentration was relatively high (approximately 250 p.p.m.), imitating real-life exposure to a household product like dishwashing liquid diluted in water and the undiluted product, respectively. Evaluation was made using a clinical scale and laser Doppler flow meter. 3 of 15 hand eczema patients developed eczema on the finger immersed in the fragrance-containing solution, 3 of 15 on the placebo finger and 3 of 15 on both fingers. Using this experimental exposure model simulating real-fife exposure, we found no association between immersion of a finger in a solution containing fragrance and development of clinically visible eczema on the finger in 15 participants previously diagnosed with hand eczema and with a positive patch test to the fragrance in question. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/297302
- author
- Heydorn, S ; Menne, T ; Andersen, KE ; Bruze, Magnus LU ; Svedman, Cecilia LU ; Basketter, D and Johansen, JD
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- carboxaldehyde, 3-cyclohexene, hydroxyisohexyl, hydroxycitronellal, fragrance allergy, hand eczema, repeated skin exposure, Lyral (R)
- in
- Contact Dermatitis
- volume
- 48
- issue
- 6
- pages
- 324 - 330
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000186231100006
- pmid:14531871
- scopus:0142257910
- ISSN
- 0105-1873
- DOI
- 10.1034/j.1600-0536.2003.00145.x
- language
- English
- LU publication?
- yes
- id
- 26947699-c821-4040-b848-e956482a93fa (old id 297302)
- date added to LUP
- 2016-04-01 11:48:11
- date last changed
- 2022-05-25 22:02:32
@article{26947699-c821-4040-b848-e956482a93fa,
abstract = {{Recently, we showed that 10.2% of consecutively patch-tested hand eczema patients had a positive patch test to a selection of fragrances containing fragrances relevant to hand exposure. In this study, we used repeated skin exposure to a patch test-positive fragrance allergen in patients previously diagnosed with hand eczema to explore whether immersion of fingers in a solution with or without the patch-test-positive fragrance allergen would cause or exacerbate hand eczema on the exposed finger. The study was double blinded and randomized. All participants had a positive patch test to either hydroxycitronellal or Lyral(R) (hydroxyisohexyl 3-cyclohexene carboxaldehyde). Each participant immersed a finger from each hand, once a day, in a solution containing the fragrance allergen or placebo. During the first 2 weeks, the concentration of fragrance allergen in the solution was low (approximately 10 p.p.m.), whilst during the following 2 weeks, the concentration was relatively high (approximately 250 p.p.m.), imitating real-life exposure to a household product like dishwashing liquid diluted in water and the undiluted product, respectively. Evaluation was made using a clinical scale and laser Doppler flow meter. 3 of 15 hand eczema patients developed eczema on the finger immersed in the fragrance-containing solution, 3 of 15 on the placebo finger and 3 of 15 on both fingers. Using this experimental exposure model simulating real-fife exposure, we found no association between immersion of a finger in a solution containing fragrance and development of clinically visible eczema on the finger in 15 participants previously diagnosed with hand eczema and with a positive patch test to the fragrance in question.}},
author = {{Heydorn, S and Menne, T and Andersen, KE and Bruze, Magnus and Svedman, Cecilia and Basketter, D and Johansen, JD}},
issn = {{0105-1873}},
keywords = {{carboxaldehyde; 3-cyclohexene; hydroxyisohexyl; hydroxycitronellal; fragrance allergy; hand eczema; repeated skin exposure; Lyral (R)}},
language = {{eng}},
number = {{6}},
pages = {{324--330}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{The fragrance hand immersion study - an experimental model simulating real-life exposure for allergic contact dermatitis on the hands}},
url = {{http://dx.doi.org/10.1034/j.1600-0536.2003.00145.x}},
doi = {{10.1034/j.1600-0536.2003.00145.x}},
volume = {{48}},
year = {{2003}},
}