Elastic, Dynamic Viscoelastic and Model-Derived Fibril-Reinforced Poroelastic Mechanical Properties of Normal and Osteoarthritic Human Femoral Condyle Cartilage
Ebrahimi, Mohammadhossein ; Finnilä, Mikko A.J. ; Turkiewicz, Aleksandra LU ; Englund, Martin LU
; Saarakkala, Simo
; Korhonen, Rami K.
and Tanska, Petri
(2021)
In Annals of Biomedical Engineering
49(9).
p.2622-2634
- Abstract
Osteoarthritis (OA) degrades articular cartilage and weakens its function. Modern fibril-reinforced poroelastic (FRPE) computational models can distinguish the mechanical properties of main cartilage constituents, namely collagen, proteoglycans, and fluid, thus, they can precisely characterize the complex mechanical behavior of the tissue. However, these properties are not known for human femoral condyle cartilage. Therefore, we aimed to characterize them from human subjects undergoing knee replacement and from deceased donors without known OA. Multi-step stress-relaxation measurements coupled with sample-specific finite element analyses were conducted to obtain the FRPE material properties. Samples were graded using OARSI scoring to... (More)
Osteoarthritis (OA) degrades articular cartilage and weakens its function. Modern fibril-reinforced poroelastic (FRPE) computational models can distinguish the mechanical properties of main cartilage constituents, namely collagen, proteoglycans, and fluid, thus, they can precisely characterize the complex mechanical behavior of the tissue. However, these properties are not known for human femoral condyle cartilage. Therefore, we aimed to characterize them from human subjects undergoing knee replacement and from deceased donors without known OA. Multi-step stress-relaxation measurements coupled with sample-specific finite element analyses were conducted to obtain the FRPE material properties. Samples were graded using OARSI scoring to determine the severity of histopathological cartilage degradation. The results suggest that alterations in the FRPE properties are not evident in the moderate stages of cartilage degradation (OARSI 2-3) as compared with normal tissue (OARSI 0-1). Drastic deterioration of the FRPE properties was observed in severely degraded cartilage (OARSI 4). We also found that the FRPE properties of femoral condyle cartilage related to the collagen network (initial fibril-network modulus) and proteoglycan matrix (non-fibrillar matrix modulus) were greater compared to tibial and patellar cartilage in OA. These findings may inform cartilage tissue-engineering efforts and help to improve the accuracy of cartilage representations in computational knee joint models.
(Less)
- author
- Ebrahimi, Mohammadhossein
; Finnilä, Mikko A.J.
; Turkiewicz, Aleksandra
LU
; Englund, Martin
LU
; Saarakkala, Simo
; Korhonen, Rami K.
and Tanska, Petri
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Articular cartilage, Finite element analysis, Mechanical properties, Mechanical testing, OARSI grading, Osteoarthritis
- in
- Annals of Biomedical Engineering
- volume
- 49
- issue
- 9
- pages
- 13 pages
- publisher
- Springer
- external identifiers
-
- scopus:85111797672
- pmid:34341898
- ISSN
- 0090-6964
- DOI
- 10.1007/s10439-021-02838-4
- language
- English
- LU publication?
- yes
- id
- 2b3dd2f1-b2cc-46fe-bf40-c7fe29ef1a62
- date added to LUP
- 2021-12-16 16:00:21
- date last changed
- 2024-06-29 23:51:34
@article{2b3dd2f1-b2cc-46fe-bf40-c7fe29ef1a62,
abstract = {{<p>Osteoarthritis (OA) degrades articular cartilage and weakens its function. Modern fibril-reinforced poroelastic (FRPE) computational models can distinguish the mechanical properties of main cartilage constituents, namely collagen, proteoglycans, and fluid, thus, they can precisely characterize the complex mechanical behavior of the tissue. However, these properties are not known for human femoral condyle cartilage. Therefore, we aimed to characterize them from human subjects undergoing knee replacement and from deceased donors without known OA. Multi-step stress-relaxation measurements coupled with sample-specific finite element analyses were conducted to obtain the FRPE material properties. Samples were graded using OARSI scoring to determine the severity of histopathological cartilage degradation. The results suggest that alterations in the FRPE properties are not evident in the moderate stages of cartilage degradation (OARSI 2-3) as compared with normal tissue (OARSI 0-1). Drastic deterioration of the FRPE properties was observed in severely degraded cartilage (OARSI 4). We also found that the FRPE properties of femoral condyle cartilage related to the collagen network (initial fibril-network modulus) and proteoglycan matrix (non-fibrillar matrix modulus) were greater compared to tibial and patellar cartilage in OA. These findings may inform cartilage tissue-engineering efforts and help to improve the accuracy of cartilage representations in computational knee joint models.</p>}},
author = {{Ebrahimi, Mohammadhossein and Finnilä, Mikko A.J. and Turkiewicz, Aleksandra and Englund, Martin and Saarakkala, Simo and Korhonen, Rami K. and Tanska, Petri}},
issn = {{0090-6964}},
keywords = {{Articular cartilage; Finite element analysis; Mechanical properties; Mechanical testing; OARSI grading; Osteoarthritis}},
language = {{eng}},
number = {{9}},
pages = {{2622--2634}},
publisher = {{Springer}},
series = {{Annals of Biomedical Engineering}},
title = {{Elastic, Dynamic Viscoelastic and Model-Derived Fibril-Reinforced Poroelastic Mechanical Properties of Normal and Osteoarthritic Human Femoral Condyle Cartilage}},
url = {{http://dx.doi.org/10.1007/s10439-021-02838-4}},
doi = {{10.1007/s10439-021-02838-4}},
volume = {{49}},
year = {{2021}},
}