Measurements of total and regional tumor blood flow and organ blood flow using 99Tcm labelled microspheres. An experimental study in rats
Sundqvist, K. ; Hafstrom, L. and Persson, B. LU
(1978)
In European Surgical Research
10(6).
p.433-443
- Abstract
Cardiac output, regional tissue and arterial tumor blood flow were studied in rats, with 99Tcm labelled microspheres using a reference sample simultaneously drawn as the spheres were injected. Both cardiac output and regional blood flow can be estimated in absolute values (ml x min-1 x g-1). Cardiac output and normal tissue blood flow were not affected by tumor growth in the liver or subcutaneously. In small tumors total blood flow was inversely proportional to tumor size, a finding similar in all 3 tumors studied. A relation found in liver as well as in subcutaneously implanted tumors. Blood flow in subcutaneous tumors was greater than muscle or skin blood flow. Benzpyrene-induced sarcoma had... (More)
Cardiac output, regional tissue and arterial tumor blood flow were studied in rats, with 99Tcm labelled microspheres using a reference sample simultaneously drawn as the spheres were injected. Both cardiac output and regional blood flow can be estimated in absolute values (ml x min-1 x g-1). Cardiac output and normal tissue blood flow were not affected by tumor growth in the liver or subcutaneously. In small tumors total blood flow was inversely proportional to tumor size, a finding similar in all 3 tumors studied. A relation found in liver as well as in subcutaneously implanted tumors. Blood flow in subcutaneous tumors was greater than muscle or skin blood flow. Benzpyrene-induced sarcoma had higher blood flow than the hepatoma and the adenocarcinoma. In big tumors the peripheral blood flow was larger than that in the centre of the tumor.
(Less)
- author
- Sundqvist, K.
; Hafstrom, L.
and Persson, B.
LU
- organization
- publishing date
- 1978-01-01
- type
- Contribution to journal
- publication status
- published
- in
- European Surgical Research
- volume
- 10
- issue
- 6
- pages
- 11 pages
- publisher
- Karger
- external identifiers
-
- pmid:216551
- scopus:0018230260
- ISSN
- 0014-312X
- DOI
- 10.1159/000128035
- language
- English
- LU publication?
- yes
- id
- 2cf3c366-5e16-4a3d-ac8c-071f7d6c1909
- date added to LUP
- 2020-08-30 20:58:01
- date last changed
- 2024-01-02 17:21:23
@article{2cf3c366-5e16-4a3d-ac8c-071f7d6c1909,
abstract = {{<p>Cardiac output, regional tissue and arterial tumor blood flow were studied in rats, with <sup>99</sup>Tc<sup>m</sup> labelled microspheres using a reference sample simultaneously drawn as the spheres were injected. Both cardiac output and regional blood flow can be estimated in absolute values (ml x min<sup>-1</sup> x g<sup>-1</sup>). Cardiac output and normal tissue blood flow were not affected by tumor growth in the liver or subcutaneously. In small tumors total blood flow was inversely proportional to tumor size, a finding similar in all 3 tumors studied. A relation found in liver as well as in subcutaneously implanted tumors. Blood flow in subcutaneous tumors was greater than muscle or skin blood flow. Benzpyrene-induced sarcoma had higher blood flow than the hepatoma and the adenocarcinoma. In big tumors the peripheral blood flow was larger than that in the centre of the tumor.</p>}},
author = {{Sundqvist, K. and Hafstrom, L. and Persson, B.}},
issn = {{0014-312X}},
language = {{eng}},
month = {{01}},
number = {{6}},
pages = {{433--443}},
publisher = {{Karger}},
series = {{European Surgical Research}},
title = {{Measurements of total and regional tumor blood flow and organ blood flow using <sup>99</sup>Tc<sup>m</sup> labelled microspheres. An experimental study in rats}},
url = {{http://dx.doi.org/10.1159/000128035}},
doi = {{10.1159/000128035}},
volume = {{10}},
year = {{1978}},
}