Changes in insulin-like growth factor 1 receptor density after transient cerebral ischemia in the rat : Lack of protection against ischemic brain damage following injection of insulin-like growth factor 1
(1993) In Journal of Cerebral Blood Flow and Metabolism 13(5). p.895-898- Abstract
Binding of 125I-insulin-like growth factor-1 (125I-IGF-1) to rat brain slices was studied after 15 min of two-vessel occlusion ischemia and 1 h to 4 days of recirculation. Ligand binding in the hippocampus increased at 6 h post ischemia in the CA1 and CA3 regions and the dentate gyrus, suggesting that the IGF-1 receptors were up-regulated, while no change was seen in neocortex and striatum. Intracerebroventricular injections of IGF-1 (2 μg) prior to and after transient cerebral ischemia did not reduce neuronal damage. The increased up-regulation on IGF-1 receptors and the absence of neuroprotection by IGF-1 suggest that the intracellular signal transduction chain activated by the IGF-1... (More)
Binding of 125I-insulin-like growth factor-1 (125I-IGF-1) to rat brain slices was studied after 15 min of two-vessel occlusion ischemia and 1 h to 4 days of recirculation. Ligand binding in the hippocampus increased at 6 h post ischemia in the CA1 and CA3 regions and the dentate gyrus, suggesting that the IGF-1 receptors were up-regulated, while no change was seen in neocortex and striatum. Intracerebroventricular injections of IGF-1 (2 μg) prior to and after transient cerebral ischemia did not reduce neuronal damage. The increased up-regulation on IGF-1 receptors and the absence of neuroprotection by IGF-1 suggest that the intracellular signal transduction chain activated by the IGF-1 receptor may be interrupted.
(Less)
- author
- Bergstedt, K. and Wieloch, T. LU
- organization
- publishing date
- 1993-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cerebral ischemia, Insulin-like growth factor 1, Neuronal damage, Protein synthesis
- in
- Journal of Cerebral Blood Flow and Metabolism
- volume
- 13
- issue
- 5
- pages
- 4 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:0027272556
- pmid:8360296
- ISSN
- 0271-678X
- DOI
- 10.1038/jcbfm.1993.112
- language
- English
- LU publication?
- yes
- id
- 2cfafd80-012b-4bfd-aeb2-954ad70ef206
- date added to LUP
- 2019-06-13 16:21:28
- date last changed
- 2024-01-01 10:18:02
@article{2cfafd80-012b-4bfd-aeb2-954ad70ef206, abstract = {{<p>Binding of <sup>125</sup>I-insulin-like growth factor-1 (<sup>125</sup>I-IGF-1) to rat brain slices was studied after 15 min of two-vessel occlusion ischemia and 1 h to 4 days of recirculation. Ligand binding in the hippocampus increased at 6 h post ischemia in the CA<sub>1</sub> and CA<sub>3</sub> regions and the dentate gyrus, suggesting that the IGF-1 receptors were up-regulated, while no change was seen in neocortex and striatum. Intracerebroventricular injections of IGF-1 (2 μg) prior to and after transient cerebral ischemia did not reduce neuronal damage. The increased up-regulation on IGF-1 receptors and the absence of neuroprotection by IGF-1 suggest that the intracellular signal transduction chain activated by the IGF-1 receptor may be interrupted.</p>}}, author = {{Bergstedt, K. and Wieloch, T.}}, issn = {{0271-678X}}, keywords = {{Cerebral ischemia; Insulin-like growth factor 1; Neuronal damage; Protein synthesis}}, language = {{eng}}, month = {{01}}, number = {{5}}, pages = {{895--898}}, publisher = {{Nature Publishing Group}}, series = {{Journal of Cerebral Blood Flow and Metabolism}}, title = {{Changes in insulin-like growth factor 1 receptor density after transient cerebral ischemia in the rat : Lack of protection against ischemic brain damage following injection of insulin-like growth factor 1}}, url = {{http://dx.doi.org/10.1038/jcbfm.1993.112}}, doi = {{10.1038/jcbfm.1993.112}}, volume = {{13}}, year = {{1993}}, }