Cutting edge : Evidence of direct TCR α-chain interaction with superantigen
(2007) In Journal of Immunology 179(5). p.2700-2704- Abstract
Superantigens are known to activate a large number of T cells. The SAg is presented by MHC class II on the APC and its classical feature is that it recognizes the variable region of the β-chain of the TCR. In this article, we report, by direct binding studies, that staphylococcal enterotoxin (SE) H (SEH), a bacterial SAg secreted by Staphylococcus aureus, instead recognizes the variable α-chain (TRAV27) of TCR. Furthermore, we show that different SAgs (e.g., SEH and SEA) can simultaneously bind to one TCR by binding the α-chain and the β-chain, respectively. Theoretical three-dimensional models of the penta complexes are presented. Hence, these findings open up a new dimension of the biology of the staphylococcal enterotoxins.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2d7421d2-8ebd-4757-9d48-2bcf15721958
- author
- Pumphrey, Nick ; Vuidepot, Annelise ; Jakobsen, Bent K ; Forsberg, Göran ; Walse, Björn LU and Lindkvist-Petersson, Karin LU
- publishing date
- 2007-09-01
- type
- Contribution to journal
- publication status
- published
- in
- Journal of Immunology
- volume
- 179
- issue
- 5
- pages
- 2700 - 2704
- publisher
- American Association of Immunologists
- external identifiers
-
- scopus:38449085891
- pmid:17709482
- ISSN
- 0022-1767
- language
- English
- LU publication?
- no
- id
- 2d7421d2-8ebd-4757-9d48-2bcf15721958
- date added to LUP
- 2017-02-15 15:05:56
- date last changed
- 2024-02-29 08:54:21
@article{2d7421d2-8ebd-4757-9d48-2bcf15721958, abstract = {{<p>Superantigens are known to activate a large number of T cells. The SAg is presented by MHC class II on the APC and its classical feature is that it recognizes the variable region of the β-chain of the TCR. In this article, we report, by direct binding studies, that staphylococcal enterotoxin (SE) H (SEH), a bacterial SAg secreted by Staphylococcus aureus, instead recognizes the variable α-chain (TRAV27) of TCR. Furthermore, we show that different SAgs (e.g., SEH and SEA) can simultaneously bind to one TCR by binding the α-chain and the β-chain, respectively. Theoretical three-dimensional models of the penta complexes are presented. Hence, these findings open up a new dimension of the biology of the staphylococcal enterotoxins.</p>}}, author = {{Pumphrey, Nick and Vuidepot, Annelise and Jakobsen, Bent K and Forsberg, Göran and Walse, Björn and Lindkvist-Petersson, Karin}}, issn = {{0022-1767}}, language = {{eng}}, month = {{09}}, number = {{5}}, pages = {{2700--2704}}, publisher = {{American Association of Immunologists}}, series = {{Journal of Immunology}}, title = {{Cutting edge : Evidence of direct TCR α-chain interaction with superantigen}}, volume = {{179}}, year = {{2007}}, }