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Effect of Continuous Positive Airway Pressure on Lipid Profiles in Obstructive Sleep Apnea : A Meta-Analysis

Chen, Baixin ; Guo, Miaolan ; Peker, Yüksel LU ; Salord, Neus ; Drager, Luciano F. ; Lorenzi-Filho, Geraldo ; Tang, Xiangdong and Li, Yun (2022) In Journal of Clinical Medicine 11(3).
Abstract

Background: Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, the effects of continuous positive airway pressure (CPAP) treatment on lipid profiles are unclear. Methods: PubMed/Medline, Embase and Cochrane were searched up to July 2021. Randomized controlled trials (RCTs) of CPAP versus controls with ≥4 weeks treatment and reported pre-and post-intervention lipid profiles were included. Weighted mean difference (WMD) was used to assess the effect size. Meta-regression was used to explore the potential moderators of post-CPAP treatment changes in lipid profiles. Results: A total of 14 RCTs with 1792 subjects were included. CPAP treatment was associated with a significant decrease in total cholesterol compared to... (More)

Background: Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, the effects of continuous positive airway pressure (CPAP) treatment on lipid profiles are unclear. Methods: PubMed/Medline, Embase and Cochrane were searched up to July 2021. Randomized controlled trials (RCTs) of CPAP versus controls with ≥4 weeks treatment and reported pre-and post-intervention lipid profiles were included. Weighted mean difference (WMD) was used to assess the effect size. Meta-regression was used to explore the potential moderators of post-CPAP treatment changes in lipid profiles. Results: A total of 14 RCTs with 1792 subjects were included. CPAP treatment was associated with a significant decrease in total cholesterol compared to controls (WMD = −0.098 mmol/L, 95% CI = −0.169 to −0.027, p = 0.007, I2 = 0.0%). No significant changes in triglyceride, high-density lipoprotein nor low-density lipoprotein were observed after CPAP treatment (all p > 0.2). Furthermore, meta-regression models showed that age, gender, body mass index, daytime sleepiness, OSA severity, follow-up study duration, CPAP compliance nor patients with cardiometabolic disease did not moderate the effects of CPAP treatment on lipid profiles (all p > 0.05). Conclusions: CPAP treatment decreases total cholesterol at a small magnitude but has no effect on other markers of dyslipidemia in OSA patients. Future studies of CPAP therapy should target combined treatment strategies with lifestyle modifications and/or anti-hyperlipidemic medications in the primary as well as secondary cardiovascular prevention models.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Continuous positive airway pressure, Lipid profile, Obstructive sleep apnea, Total cholesterol
in
Journal of Clinical Medicine
volume
11
issue
3
article number
596
publisher
MDPI AG
external identifiers
  • pmid:35160050
  • scopus:85123380276
ISSN
2077-0383
DOI
10.3390/jcm11030596
language
English
LU publication?
yes
id
2f2ac94b-54ed-4a65-a569-d1c00c54e6cf
date added to LUP
2022-03-18 14:33:15
date last changed
2024-07-11 13:47:58
@article{2f2ac94b-54ed-4a65-a569-d1c00c54e6cf,
  abstract     = {{<p>Background: Obstructive sleep apnea (OSA) is associated with dyslipidemia. However, the effects of continuous positive airway pressure (CPAP) treatment on lipid profiles are unclear. Methods: PubMed/Medline, Embase and Cochrane were searched up to July 2021. Randomized controlled trials (RCTs) of CPAP versus controls with ≥4 weeks treatment and reported pre-and post-intervention lipid profiles were included. Weighted mean difference (WMD) was used to assess the effect size. Meta-regression was used to explore the potential moderators of post-CPAP treatment changes in lipid profiles. Results: A total of 14 RCTs with 1792 subjects were included. CPAP treatment was associated with a significant decrease in total cholesterol compared to controls (WMD = −0.098 mmol/L, 95% CI = −0.169 to −0.027, p = 0.007, I<sup>2</sup> = 0.0%). No significant changes in triglyceride, high-density lipoprotein nor low-density lipoprotein were observed after CPAP treatment (all p &gt; 0.2). Furthermore, meta-regression models showed that age, gender, body mass index, daytime sleepiness, OSA severity, follow-up study duration, CPAP compliance nor patients with cardiometabolic disease did not moderate the effects of CPAP treatment on lipid profiles (all p &gt; 0.05). Conclusions: CPAP treatment decreases total cholesterol at a small magnitude but has no effect on other markers of dyslipidemia in OSA patients. Future studies of CPAP therapy should target combined treatment strategies with lifestyle modifications and/or anti-hyperlipidemic medications in the primary as well as secondary cardiovascular prevention models.</p>}},
  author       = {{Chen, Baixin and Guo, Miaolan and Peker, Yüksel and Salord, Neus and Drager, Luciano F. and Lorenzi-Filho, Geraldo and Tang, Xiangdong and Li, Yun}},
  issn         = {{2077-0383}},
  keywords     = {{Continuous positive airway pressure; Lipid profile; Obstructive sleep apnea; Total cholesterol}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of Clinical Medicine}},
  title        = {{Effect of Continuous Positive Airway Pressure on Lipid Profiles in Obstructive Sleep Apnea : A Meta-Analysis}},
  url          = {{http://dx.doi.org/10.3390/jcm11030596}},
  doi          = {{10.3390/jcm11030596}},
  volume       = {{11}},
  year         = {{2022}},
}