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Towards enhanced cancer therapy; Leveraging bioresorbable optical fibers for improved treatment outcomes

Pandayil, Jawad T. ; Šušnjar, Stefan LU orcid ; Cortese, Lorenzo ; Boetti, Nadia G. ; Swartling, Johannes LU ; Janner, Davide and Durduran, Turgut (2024) 2024 EOS Annual Meeting, EOSAM 2024 309.
Abstract

Bioresorbable photonic implants are emerging as potential material choice for interstitial theranostic and monitoring applications. They gradually dissolve within the physiological environment in a clinically relevant period, eliminating the need for extraction surgeries. In the present study, we tested the suitability of in-house fabricated bioresorbable optical fibres based on calcium phosphate (CaP) glass for diffuse correlation spectroscopic (DCS) and diffuse fluorescence tomographic (DFT) applications. The results represent the potential of bioresorbable fibers for the monitoring of interstitial microvascular blood flow and the spatial distribution of fluorescent photosensitizer drugs that are administered prior to therapies.... (More)

Bioresorbable photonic implants are emerging as potential material choice for interstitial theranostic and monitoring applications. They gradually dissolve within the physiological environment in a clinically relevant period, eliminating the need for extraction surgeries. In the present study, we tested the suitability of in-house fabricated bioresorbable optical fibres based on calcium phosphate (CaP) glass for diffuse correlation spectroscopic (DCS) and diffuse fluorescence tomographic (DFT) applications. The results represent the potential of bioresorbable fibers for the monitoring of interstitial microvascular blood flow and the spatial distribution of fluorescent photosensitizer drugs that are administered prior to therapies. Together or separate, the continuous monitoring of these parameters can have significant implications in planning, optimizing and in predicting or monitoring the outcomes in interstitial photodynamic therapy (PDT).

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Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
EPJ Web of Conferences
volume
309
article number
04025
conference name
2024 EOS Annual Meeting, EOSAM 2024
conference location
Naples, Italy
conference dates
2024-09-09 - 2024-09-13
external identifiers
  • scopus:85212477465
DOI
10.1051/epjconf/202430904025
language
English
LU publication?
yes
id
2f5587a4-3fa8-4f9a-81ba-32f6b2403aa4
date added to LUP
2025-01-22 11:22:32
date last changed
2025-04-16 18:00:30
@inproceedings{2f5587a4-3fa8-4f9a-81ba-32f6b2403aa4,
  abstract     = {{<p>Bioresorbable photonic implants are emerging as potential material choice for interstitial theranostic and monitoring applications. They gradually dissolve within the physiological environment in a clinically relevant period, eliminating the need for extraction surgeries. In the present study, we tested the suitability of in-house fabricated bioresorbable optical fibres based on calcium phosphate (CaP) glass for diffuse correlation spectroscopic (DCS) and diffuse fluorescence tomographic (DFT) applications. The results represent the potential of bioresorbable fibers for the monitoring of interstitial microvascular blood flow and the spatial distribution of fluorescent photosensitizer drugs that are administered prior to therapies. Together or separate, the continuous monitoring of these parameters can have significant implications in planning, optimizing and in predicting or monitoring the outcomes in interstitial photodynamic therapy (PDT).</p>}},
  author       = {{Pandayil, Jawad T. and Šušnjar, Stefan and Cortese, Lorenzo and Boetti, Nadia G. and Swartling, Johannes and Janner, Davide and Durduran, Turgut}},
  booktitle    = {{EPJ Web of Conferences}},
  language     = {{eng}},
  title        = {{Towards enhanced cancer therapy; Leveraging bioresorbable optical fibers for improved treatment outcomes}},
  url          = {{http://dx.doi.org/10.1051/epjconf/202430904025}},
  doi          = {{10.1051/epjconf/202430904025}},
  volume       = {{309}},
  year         = {{2024}},
}