Genistein as an anti-inflammatory agent
(2003) In Inflammation Research 52(8). p.341-346- Abstract
- Objective and design: The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice. Methods: Delayed type hypersensitivity reaction (DTH) to oxazolone and the inflammatory response to olive oil were measured in mice treated with genistein. In addition, the impact of genistein treatment on disease progression and outcome of collagen induced arthritis (CIA) was examined. Results: The DTH reaction to oxazolone and the granulocyte-mediated response were significantly suppressed in genistein-treated as compared to control mice. Also, genistein treatment led to decreased levels of... (More)
- Objective and design: The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice. Methods: Delayed type hypersensitivity reaction (DTH) to oxazolone and the inflammatory response to olive oil were measured in mice treated with genistein. In addition, the impact of genistein treatment on disease progression and outcome of collagen induced arthritis (CIA) was examined. Results: The DTH reaction to oxazolone and the granulocyte-mediated response were significantly suppressed in genistein-treated as compared to control mice. Also, genistein treatment led to decreased levels of oxazolone-specific antibodies. Histologically, mice exposed to genistein and immunized with collagen II displayed somewhat lower degree of inflammation and joint destruction. In addition, serum levels of autoantibodies to collagen II were significantly lower following genistein-treatment in immunized mice. Conclusion: We conclude that genistein exerts evident anti-inflammatory properties affecting granulocytes, monocytes, and lymphocytes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/302275
- author
- Verdrengh, M ; Jonsson, IM ; Holmdahl, Rikard LU and Tarkowski, A
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- delayed type, lymphocytes, collagen induced arthritis, granulocytes, hypersensitivity reaction
- in
- Inflammation Research
- volume
- 52
- issue
- 8
- pages
- 341 - 346
- publisher
- Birkhäuser Verlag
- external identifiers
-
- pmid:14504672
- wos:000184984000004
- scopus:0041661977
- ISSN
- 1420-908X
- DOI
- 10.1007/s00011-003-1182-8
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- 1cb19869-a3c3-4a43-83c9-9373ea3ac131 (old id 302275)
- date added to LUP
- 2016-04-01 11:51:34
- date last changed
- 2022-04-28 20:55:48
@article{1cb19869-a3c3-4a43-83c9-9373ea3ac131,
abstract = {{Objective and design: The aim of this study was to investigate the impact of the isoflavone genistein on in vivo cell-mediated responses. In addition, we wanted to study the influence of genistein on collagen induced arthritis (CIA) in mice. Methods: Delayed type hypersensitivity reaction (DTH) to oxazolone and the inflammatory response to olive oil were measured in mice treated with genistein. In addition, the impact of genistein treatment on disease progression and outcome of collagen induced arthritis (CIA) was examined. Results: The DTH reaction to oxazolone and the granulocyte-mediated response were significantly suppressed in genistein-treated as compared to control mice. Also, genistein treatment led to decreased levels of oxazolone-specific antibodies. Histologically, mice exposed to genistein and immunized with collagen II displayed somewhat lower degree of inflammation and joint destruction. In addition, serum levels of autoantibodies to collagen II were significantly lower following genistein-treatment in immunized mice. Conclusion: We conclude that genistein exerts evident anti-inflammatory properties affecting granulocytes, monocytes, and lymphocytes.}},
author = {{Verdrengh, M and Jonsson, IM and Holmdahl, Rikard and Tarkowski, A}},
issn = {{1420-908X}},
keywords = {{delayed type; lymphocytes; collagen induced arthritis; granulocytes; hypersensitivity reaction}},
language = {{eng}},
number = {{8}},
pages = {{341--346}},
publisher = {{Birkhäuser Verlag}},
series = {{Inflammation Research}},
title = {{Genistein as an anti-inflammatory agent}},
url = {{http://dx.doi.org/10.1007/s00011-003-1182-8}},
doi = {{10.1007/s00011-003-1182-8}},
volume = {{52}},
year = {{2003}},
}