Does aspirin protect against Alzheimer's dementia? A study in a Swedish population-based sample aged >= 80 years
(2003) In European Journal of Clinical Pharmacology 59(4). p.313-319- Abstract
- Objective. It has been reported that aspirin and other non-steroidal anti-inflammatory drugs (NSAID) may protect against dementia of Alzheimer's type and/or vascular dementia. However, co-morbidity and the dose of aspirin may be critical. A major indication for low-dose aspirin is prophylaxis after stroke and transient ischaemic attacks, conditions that may obscure an anti-dementia effect by the drug. Alternatively, low-dose aspirin may be insufficient if the protective effect is due to an anti-inflammatory mechanism. The aim of this study was to assess whether high-dose or low-dose aspirin may protect against Alzheimer's dementia in subjects aged greater than or equal to80 years. For comparison, effects of (other) NSAID, paracetamol and... (More)
- Objective. It has been reported that aspirin and other non-steroidal anti-inflammatory drugs (NSAID) may protect against dementia of Alzheimer's type and/or vascular dementia. However, co-morbidity and the dose of aspirin may be critical. A major indication for low-dose aspirin is prophylaxis after stroke and transient ischaemic attacks, conditions that may obscure an anti-dementia effect by the drug. Alternatively, low-dose aspirin may be insufficient if the protective effect is due to an anti-inflammatory mechanism. The aim of this study was to assess whether high-dose or low-dose aspirin may protect against Alzheimer's dementia in subjects aged greater than or equal to80 years. For comparison, effects of (other) NSAID, paracetamol and D-propoxyphene were studied. Methods. Global, cross-sectional, and longitudinal (1991-2000) epidemiological analyses of clinical, cognitive and drug treatment data on 702 individuals 80 years old or more (351 twin pairs of same sex), all alive at inclusion: mean age 83.9 years (80-99 years). Calculations were made with logistic regression of associations between use of various analgesics and cognitive function, after adjustment for age, gender, and cardiovascular and cerebrovascular diseases. Results. Users of high-dose aspirin had significantly lower prevalence of Alzheimer's dementia and better-maintained cognitive function than non-users. There were numerically similar but not significant associations with use of low-dose aspirin and other NSAID. There were no such associations with use of either paracetamol or D-propoxyphene. Conclusion. Aspirin might protect against Alzheimer's disease, but controlled trials are warranted. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/303958
- author
- Nilsson, SE ; Johansson, B ; Takkinen, S ; Berg, S ; Zarit, S ; McClearn, G and Melander, Arne LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer, aspirin, NSAID
- in
- European Journal of Clinical Pharmacology
- volume
- 59
- issue
- 4
- pages
- 313 - 319
- publisher
- Springer
- external identifiers
-
- wos:000184777200008
- pmid:12827329
- scopus:0042913340
- pmid:12827329
- ISSN
- 1432-1041
- DOI
- 10.1007/s00228-003-0618-y
- language
- English
- LU publication?
- yes
- id
- 7dfa3d7d-db3c-4ce0-86c0-6bfa58356bc8 (old id 303958)
- date added to LUP
- 2016-04-01 15:46:40
- date last changed
- 2022-02-20 00:57:51
@article{7dfa3d7d-db3c-4ce0-86c0-6bfa58356bc8,
abstract = {{Objective. It has been reported that aspirin and other non-steroidal anti-inflammatory drugs (NSAID) may protect against dementia of Alzheimer's type and/or vascular dementia. However, co-morbidity and the dose of aspirin may be critical. A major indication for low-dose aspirin is prophylaxis after stroke and transient ischaemic attacks, conditions that may obscure an anti-dementia effect by the drug. Alternatively, low-dose aspirin may be insufficient if the protective effect is due to an anti-inflammatory mechanism. The aim of this study was to assess whether high-dose or low-dose aspirin may protect against Alzheimer's dementia in subjects aged greater than or equal to80 years. For comparison, effects of (other) NSAID, paracetamol and D-propoxyphene were studied. Methods. Global, cross-sectional, and longitudinal (1991-2000) epidemiological analyses of clinical, cognitive and drug treatment data on 702 individuals 80 years old or more (351 twin pairs of same sex), all alive at inclusion: mean age 83.9 years (80-99 years). Calculations were made with logistic regression of associations between use of various analgesics and cognitive function, after adjustment for age, gender, and cardiovascular and cerebrovascular diseases. Results. Users of high-dose aspirin had significantly lower prevalence of Alzheimer's dementia and better-maintained cognitive function than non-users. There were numerically similar but not significant associations with use of low-dose aspirin and other NSAID. There were no such associations with use of either paracetamol or D-propoxyphene. Conclusion. Aspirin might protect against Alzheimer's disease, but controlled trials are warranted.}},
author = {{Nilsson, SE and Johansson, B and Takkinen, S and Berg, S and Zarit, S and McClearn, G and Melander, Arne}},
issn = {{1432-1041}},
keywords = {{Alzheimer; aspirin; NSAID}},
language = {{eng}},
number = {{4}},
pages = {{313--319}},
publisher = {{Springer}},
series = {{European Journal of Clinical Pharmacology}},
title = {{Does aspirin protect against Alzheimer's dementia? A study in a Swedish population-based sample aged >= 80 years}},
url = {{http://dx.doi.org/10.1007/s00228-003-0618-y}},
doi = {{10.1007/s00228-003-0618-y}},
volume = {{59}},
year = {{2003}},
}