Selected contribution: role of spleen emptying in prolonging apneas in humans
Schagatay, Erica ; Andersson, Johan P. A. LU
; Hallén, Magnus
LU
and Pålsson, Birger
LU
(2001)
In Journal of Applied Physiology
90(4).
p.9-1623
- Abstract
- This study addressed the interaction between short-term adaptation to apneas with face immersion and erythrocyte release from the spleen. Twenty healthy volunteers, including ten splenectomized subjects, participated. After prone rest, they performed five maximal-duration apneas with face immersion in 10 degrees C water, with 2-min intervals. Cardiorespiratory parameters and venous blood samples were collected. In subjects with spleens, hematocrit and hemoglobin concentration increased by 6.4% and 3.3%, respectively, over the serial apneas and returned to baseline 10 min after the series. A delay of the physiological breaking point of apnea, by 30.5% (17 s), was seen only in this group. These parameters did not change in the splenectomized... (More)
- This study addressed the interaction between short-term adaptation to apneas with face immersion and erythrocyte release from the spleen. Twenty healthy volunteers, including ten splenectomized subjects, participated. After prone rest, they performed five maximal-duration apneas with face immersion in 10 degrees C water, with 2-min intervals. Cardiorespiratory parameters and venous blood samples were collected. In subjects with spleens, hematocrit and hemoglobin concentration increased by 6.4% and 3.3%, respectively, over the serial apneas and returned to baseline 10 min after the series. A delay of the physiological breaking point of apnea, by 30.5% (17 s), was seen only in this group. These parameters did not change in the splenectomized group. Plasma protein concentration, preapneic alveolar PCO2, inspired lung volume, and diving bradycardia remained unchanged throughout the series in both groups. Serial apneas thus triggered the hematological changes that have been previously observed after long apneic diving shifts; they were rapidly reversed and did not occur in splenectomized subjects. This suggests that splenic contraction occurs in humans as a part of the diving response and may prolong repeated apneas. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3052317
- author
- Schagatay, Erica
; Andersson, Johan P. A.
LU
; Hallén, Magnus
LU
and Pålsson, Birger
LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Apnea, Blood Pressure/physiology, Blood Proteins/metabolism, Carbon Dioxide/blood, Face, Female, Heart Rate/physiology, Hematocrit, Hemoglobins/metabolism, Humans, Immersion, Lung Volume Measurements, Male, Regional Blood Flow/physiology, Spleen/ physiology, Splenectomy
- in
- Journal of Applied Physiology
- volume
- 90
- issue
- 4
- pages
- 9 - 1623
- publisher
- American Physiological Society
- external identifiers
-
- scopus:0035107586
- ISSN
- 1522-1601
- language
- English
- LU publication?
- yes
- id
- d809e502-1468-41c1-9f6b-61004b896e1c (old id 3052317)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/11247970
- http://jap.physiology.org/content/90/4/1623.long
- date added to LUP
- 2016-04-04 08:12:44
- date last changed
- 2022-11-18 09:34:45
@article{d809e502-1468-41c1-9f6b-61004b896e1c,
abstract = {{This study addressed the interaction between short-term adaptation to apneas with face immersion and erythrocyte release from the spleen. Twenty healthy volunteers, including ten splenectomized subjects, participated. After prone rest, they performed five maximal-duration apneas with face immersion in 10 degrees C water, with 2-min intervals. Cardiorespiratory parameters and venous blood samples were collected. In subjects with spleens, hematocrit and hemoglobin concentration increased by 6.4% and 3.3%, respectively, over the serial apneas and returned to baseline 10 min after the series. A delay of the physiological breaking point of apnea, by 30.5% (17 s), was seen only in this group. These parameters did not change in the splenectomized group. Plasma protein concentration, preapneic alveolar PCO2, inspired lung volume, and diving bradycardia remained unchanged throughout the series in both groups. Serial apneas thus triggered the hematological changes that have been previously observed after long apneic diving shifts; they were rapidly reversed and did not occur in splenectomized subjects. This suggests that splenic contraction occurs in humans as a part of the diving response and may prolong repeated apneas.}},
author = {{Schagatay, Erica and Andersson, Johan P. A. and Hallén, Magnus and Pålsson, Birger}},
issn = {{1522-1601}},
keywords = {{Adult; Apnea; Blood Pressure/physiology; Blood Proteins/metabolism; Carbon Dioxide/blood; Face; Female; Heart Rate/physiology; Hematocrit; Hemoglobins/metabolism; Humans; Immersion; Lung Volume Measurements; Male; Regional Blood Flow/physiology; Spleen/ physiology; Splenectomy}},
language = {{eng}},
number = {{4}},
pages = {{9--1623}},
publisher = {{American Physiological Society}},
series = {{Journal of Applied Physiology}},
title = {{Selected contribution: role of spleen emptying in prolonging apneas in humans}},
url = {{http://www.ncbi.nlm.nih.gov/pubmed/11247970}},
volume = {{90}},
year = {{2001}},
}