Sequential chemotherapy/radiotherapy was comparable with concurrent chemoradiotherapy for stage I/II NK/T-cell lymphoma

Kwong, Y. L.; Kim, S. J.; Tse, E.; Oh, S. Y.; Kwak, J. Y.; Eom, H. S.; Do, Y. R.; Mun, Y. C.; Lee, S. R.; Shin, H. J.; Suh, C.; Chuang, S. S.; Lee, Y. S.; Lim, S. T.; Izutsu, K.; Suzuki, R.; Relander, T.; d'Amore, F.; Schmitz, N.; Jaccard, A.; Kim, W. S.

Sequential chemotherapy/radiotherapy was comparable with concurrent chemoradiotherapy for stage I/II NK/T-cell lymphoma

Mark

Kwong, Y. L. ; Kim, S. J. ; Tse, E. ; Oh, S. Y. ; Kwak, J. Y. ; Eom, H. S. ; Do, Y. R. ; Mun, Y. C. ; Lee, S. R. and Shin, H. J. , et al. (2018) In Annals of Oncology 29(1). p.256-263

Abstract: Background: In stage I/II natural killer (NK)/T-cell lymphoma, concurrent chemoradiotherapy (CCRT) had previously been shown to result in superior outcome compared with anthracycline-containing regimens, which have since been considered ineffective. The role of CCRT in comparison with approaches employing nonanthracycline-containing chemotherapy (CT) and sequential radiotherapy (RT) in such patients remains to be defined. Patients and methods: Three hundred and three untreated patients (207 men, 96 women; median age: 51, 18-86 years) with stage I/II NK/T-cell lymphoma who had received nonanthracycline-containing regimens were collected from an international consortium and retrospectively analyzed. Treatment included single modality (CT... (More); Background: In stage I/II natural killer (NK)/T-cell lymphoma, concurrent chemoradiotherapy (CCRT) had previously been shown to result in superior outcome compared with anthracycline-containing regimens, which have since been considered ineffective. The role of CCRT in comparison with approaches employing nonanthracycline-containing chemotherapy (CT) and sequential radiotherapy (RT) in such patients remains to be defined. Patients and methods: Three hundred and three untreated patients (207 men, 96 women; median age: 51, 18-86 years) with stage I/II NK/T-cell lymphoma who had received nonanthracycline-containing regimens were collected from an international consortium and retrospectively analyzed. Treatment included single modality (CT and RT), sequential modalities (CT+RT; RT+CT) and concurrent modalities (CCRT; CCRT+CT). The impact of clinicopathologic parameters and types of treatment on complete response (CR) rate, progression-free-survival (PFS) and overall-survival (OS) was evaluated. Results: For CR, stage (P=0.027), prognostic index for NK/T-cell lymphoma (PINK) (P=0.026) and types of initial treatment (P=0.011) were significant prognostic factors on multivariate analysis. On Cox regression analysis, ECOG performance score (P=0.021) and PINK-EBV DNA (PINK-E) (P=0.002) significantly impacted on PFS; whereas ECOG performance score (P=0.008) and stage (P<0.001) significantly impacted on OS. For comparing CCRT6CT and sequential CT+RT, CCRT6CT patients (n=190) were similar to sequential CT+RT patients (n=54) in all evaluated clinicopathologic parameters except two significantly superior features (higher proportion of undetectable circulating EBV DNA on diagnosis and lower PINK-E scores). Despite more favorable pre-treatment characteristics, CCRT6CT patients had CR rate, PFS and OS comparable with sequential CT+RT patients on multivariate and Cox regression analyses. Conclusions: In stage I/II NK/T-cell lymphomas, when effective chemotherapeutic regimens were used, CCRT and sequential CT+RT gave similar outcome.
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Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/308fa5ad-0013-4958-b944-4fb765460c39

author

Kwong, Y. L. ; Kim, S. J. ; Tse, E. ; Oh, S. Y. ; Kwak, J. Y. ; Eom, H. S. ; Do, Y. R. ; Mun, Y. C. ; Lee, S. R. and Shin, H. J. , et al. (More)

Kwong, Y. L. ; Kim, S. J. ; Tse, E. ; Oh, S. Y. ; Kwak, J. Y. ; Eom, H. S. ; Do, Y. R. ; Mun, Y. C. ; Lee, S. R. ; Shin, H. J. ; Suh, C. ; Chuang, S. S. ; Lee, Y. S. ; Lim, S. T. ; Izutsu, K. ; Suzuki, R. ; Relander, T. ^LU ; d'Amore, F. ; Schmitz, N. ; Jaccard, A. and Kim, W. S. (Less)

organization

BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

publishing date

2018-01-01

type

Contribution to journal

publication status

published

subject

Cancer and Oncology

keywords

Concurrent chemoradiotherapy, Sequential chemotherapy and radiotherapy, Stage I/II NK/T-cell lymphomas

in

Annals of Oncology

volume

29

issue

1

article number

mdx684

pages

256 - 263

publisher

Oxford University Press

external identifiers

scopus:85041196676
pmid:29077846

ISSN

0923-7534

DOI

10.1093/annonc/mdx684

language

English

LU publication?

yes

id

308fa5ad-0013-4958-b944-4fb765460c39

date added to LUP

2018-02-23 10:58:26

date last changed

2024-04-01 01:39:58

@article{308fa5ad-0013-4958-b944-4fb765460c39,
  abstract     = {{<p>Background: In stage I/II natural killer (NK)/T-cell lymphoma, concurrent chemoradiotherapy (CCRT) had previously been shown to result in superior outcome compared with anthracycline-containing regimens, which have since been considered ineffective. The role of CCRT in comparison with approaches employing nonanthracycline-containing chemotherapy (CT) and sequential radiotherapy (RT) in such patients remains to be defined. Patients and methods: Three hundred and three untreated patients (207 men, 96 women; median age: 51, 18-86 years) with stage I/II NK/T-cell lymphoma who had received nonanthracycline-containing regimens were collected from an international consortium and retrospectively analyzed. Treatment included single modality (CT and RT), sequential modalities (CT+RT; RT+CT) and concurrent modalities (CCRT; CCRT+CT). The impact of clinicopathologic parameters and types of treatment on complete response (CR) rate, progression-free-survival (PFS) and overall-survival (OS) was evaluated. Results: For CR, stage (P=0.027), prognostic index for NK/T-cell lymphoma (PINK) (P=0.026) and types of initial treatment (P=0.011) were significant prognostic factors on multivariate analysis. On Cox regression analysis, ECOG performance score (P=0.021) and PINK-EBV DNA (PINK-E) (P=0.002) significantly impacted on PFS; whereas ECOG performance score (P=0.008) and stage (P&lt;0.001) significantly impacted on OS. For comparing CCRT6CT and sequential CT+RT, CCRT6CT patients (n=190) were similar to sequential CT+RT patients (n=54) in all evaluated clinicopathologic parameters except two significantly superior features (higher proportion of undetectable circulating EBV DNA on diagnosis and lower PINK-E scores). Despite more favorable pre-treatment characteristics, CCRT6CT patients had CR rate, PFS and OS comparable with sequential CT+RT patients on multivariate and Cox regression analyses. Conclusions: In stage I/II NK/T-cell lymphomas, when effective chemotherapeutic regimens were used, CCRT and sequential CT+RT gave similar outcome.</p>}},
  author       = {{Kwong, Y. L. and Kim, S. J. and Tse, E. and Oh, S. Y. and Kwak, J. Y. and Eom, H. S. and Do, Y. R. and Mun, Y. C. and Lee, S. R. and Shin, H. J. and Suh, C. and Chuang, S. S. and Lee, Y. S. and Lim, S. T. and Izutsu, K. and Suzuki, R. and Relander, T. and d'Amore, F. and Schmitz, N. and Jaccard, A. and Kim, W. S.}},
  issn         = {{0923-7534}},
  keywords     = {{Concurrent chemoradiotherapy; Sequential chemotherapy and radiotherapy; Stage I/II NK/T-cell lymphomas}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{256--263}},
  publisher    = {{Oxford University Press}},
  series       = {{Annals of Oncology}},
  title        = {{Sequential chemotherapy/radiotherapy was comparable with concurrent chemoradiotherapy for stage I/II NK/T-cell lymphoma}},
  url          = {{http://dx.doi.org/10.1093/annonc/mdx684}},
  doi          = {{10.1093/annonc/mdx684}},
  volume       = {{29}},
  year         = {{2018}},
}

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Sequential chemotherapy/radiotherapy was comparable with concurrent chemoradiotherapy for stage I/II NK/T-cell lymphoma