Prospective study of adult mental disturbance in offspring of women with psychosis
(2003) In Archives of General Psychiatry 60(5). p.473-480- Abstract
- Background: The high-risk method is an important strategy for studying the antecedents and causes of schizophrenia and other psychoses'. The Swedish High-Risk Project is a prospective longitudinal study of offspring of women with a history of schizophrenic, schizoaffective, affective, or unspecified functional psychoses and control women with no history of psychosis. The offspring and their environments were studied beginning before birth, and again during,childhood. This article reports the mental outcome results from the first adult follow-up at age 22 years. Methods: Of 178 offspring, 166 (93%) were followed up and blindly assessed using standardized methods, including a self-report scale for mental symptoms and the Structured Clinical... (More)
- Background: The high-risk method is an important strategy for studying the antecedents and causes of schizophrenia and other psychoses'. The Swedish High-Risk Project is a prospective longitudinal study of offspring of women with a history of schizophrenic, schizoaffective, affective, or unspecified functional psychoses and control women with no history of psychosis. The offspring and their environments were studied beginning before birth, and again during,childhood. This article reports the mental outcome results from the first adult follow-up at age 22 years. Methods: Of 178 offspring, 166 (93%) were followed up and blindly assessed using standardized methods, including a self-report scale for mental symptoms and the Structured Clinical Interview for DSM-III-R. Results: Compared with controls (n = 91), the offspring of mothers with schizophrenia (n = 28) showed a significantly increased frequency of DSM-III-R Axis I and Axis II disorders, poor global functioning, high Symptom Checklist-90 scores, and a history of mental, health care and psychopharmacologic medication use. Offspring of mothers with affective disorders (n = 22) showed high Symptom Checklist-90 scores, more frequent poor functioning, and receipt of mental health care, with a significant increase in Axis I depressive disorders and no increase in Axis II disorders. The extension of schizophrenia and affective risk groups to include additional maternal "spectrum cases" (10 and 15 individuals, respectively) generally yielded similar results. Conclusions: Maternal schizophrenia is associated with widespread increases in offspring mental disturbance in adolescence and young adulthood, differing from offspring disturbance associated with maternal affective disorder. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/312290
- author
- Schubert, Erland LU and McNeil, Thomas LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Archives of General Psychiatry
- volume
- 60
- issue
- 5
- pages
- 473 - 480
- publisher
- American Medical Association
- external identifiers
-
- wos:000182735000005
- pmid:12742868
- scopus:0038643576
- ISSN
- 0003-990X
- language
- English
- LU publication?
- yes
- id
- 99939be7-e539-458e-856d-2b4c251336ac (old id 312290)
- alternative location
- http://archpsyc.ama-assn.org/cgi/content/abstract/60/5/473
- date added to LUP
- 2016-04-01 12:22:38
- date last changed
- 2022-04-05 21:27:50
@article{99939be7-e539-458e-856d-2b4c251336ac,
abstract = {{Background: The high-risk method is an important strategy for studying the antecedents and causes of schizophrenia and other psychoses'. The Swedish High-Risk Project is a prospective longitudinal study of offspring of women with a history of schizophrenic, schizoaffective, affective, or unspecified functional psychoses and control women with no history of psychosis. The offspring and their environments were studied beginning before birth, and again during,childhood. This article reports the mental outcome results from the first adult follow-up at age 22 years. Methods: Of 178 offspring, 166 (93%) were followed up and blindly assessed using standardized methods, including a self-report scale for mental symptoms and the Structured Clinical Interview for DSM-III-R. Results: Compared with controls (n = 91), the offspring of mothers with schizophrenia (n = 28) showed a significantly increased frequency of DSM-III-R Axis I and Axis II disorders, poor global functioning, high Symptom Checklist-90 scores, and a history of mental, health care and psychopharmacologic medication use. Offspring of mothers with affective disorders (n = 22) showed high Symptom Checklist-90 scores, more frequent poor functioning, and receipt of mental health care, with a significant increase in Axis I depressive disorders and no increase in Axis II disorders. The extension of schizophrenia and affective risk groups to include additional maternal "spectrum cases" (10 and 15 individuals, respectively) generally yielded similar results. Conclusions: Maternal schizophrenia is associated with widespread increases in offspring mental disturbance in adolescence and young adulthood, differing from offspring disturbance associated with maternal affective disorder.}},
author = {{Schubert, Erland and McNeil, Thomas}},
issn = {{0003-990X}},
language = {{eng}},
number = {{5}},
pages = {{473--480}},
publisher = {{American Medical Association}},
series = {{Archives of General Psychiatry}},
title = {{Prospective study of adult mental disturbance in offspring of women with psychosis}},
url = {{http://archpsyc.ama-assn.org/cgi/content/abstract/60/5/473}},
volume = {{60}},
year = {{2003}},
}