Effects of thermal degradation products from polyurethane foams based on toluene diisocyanate and diphenylmethane diisocyanate on isolated, perfused lung of guinea pig
(2003) In Scandinavian Journal of Work, Environment and Health 29(2). p.152-158- Abstract
- Objectives The composition of thermal degradation products from two types of polyurethane foams, one based on toluene diisocyanate (TDI) and the other on diphenylmethane diisocyanate (MDI), was analyzed and their toxic lung effects were compared. Methods Isolated perfused lungs of guinea pig were subjected to thermal decomposition products of polyurethane foams from an aerosol generator with compartments for diluting, mixing, and sampling. Results Thermal degradation of MDI-based polyurethane foams released MDI, phenyl isocyanate, and methyl isocyanate. The emitted particulate fraction was 75% for MDI, whereas that for TDI from TDI-based polyurethane foam was 3%. Thermal degradation products from MDI-based foam caused a pronounced... (More)
- Objectives The composition of thermal degradation products from two types of polyurethane foams, one based on toluene diisocyanate (TDI) and the other on diphenylmethane diisocyanate (MDI), was analyzed and their toxic lung effects were compared. Methods Isolated perfused lungs of guinea pig were subjected to thermal decomposition products of polyurethane foams from an aerosol generator with compartments for diluting, mixing, and sampling. Results Thermal degradation of MDI-based polyurethane foams released MDI, phenyl isocyanate, and methyl isocyanate. The emitted particulate fraction was 75% for MDI, whereas that for TDI from TDI-based polyurethane foam was 3%. Thermal degradation products from MDI-based foam caused a pronounced dose-dependent decrease in the measured lung function parameters (conductance and compliance). In contrast, the thermal degradation products from TDI-based foam did not cause any decrease in lung function. Conclusions Thermal degradation products generated from MDI-based polyurethane foam were more toxic to the lung than those generated from TDI-based polyurethane foam. This difference was probable due to MDI in the particle phase. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/313903
- author
- Lastbom, L ; Colmsjo, A ; Johansson, R ; Karlsson, Daniel LU ; Melin, J ; Nordqvist, Y and Skarping, Gunnar LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- phenyl isocyanate, mineral wool, aerosol, methyl isocyanate
- in
- Scandinavian Journal of Work, Environment and Health
- volume
- 29
- issue
- 2
- pages
- 152 - 158
- publisher
- Finnish Institute of Occupational Health
- external identifiers
-
- pmid:12718501
- wos:000182038500010
- scopus:0242668732
- ISSN
- 0355-3140
- language
- English
- LU publication?
- yes
- id
- 89add9b0-ccd0-4ba6-acf9-6af2922195d6 (old id 313903)
- alternative location
- http://www.sjweh.fi/show_abstract.php?abstract_id=717
- date added to LUP
- 2016-04-01 11:35:00
- date last changed
- 2022-01-26 07:15:10
@article{89add9b0-ccd0-4ba6-acf9-6af2922195d6, abstract = {{Objectives The composition of thermal degradation products from two types of polyurethane foams, one based on toluene diisocyanate (TDI) and the other on diphenylmethane diisocyanate (MDI), was analyzed and their toxic lung effects were compared. Methods Isolated perfused lungs of guinea pig were subjected to thermal decomposition products of polyurethane foams from an aerosol generator with compartments for diluting, mixing, and sampling. Results Thermal degradation of MDI-based polyurethane foams released MDI, phenyl isocyanate, and methyl isocyanate. The emitted particulate fraction was 75% for MDI, whereas that for TDI from TDI-based polyurethane foam was 3%. Thermal degradation products from MDI-based foam caused a pronounced dose-dependent decrease in the measured lung function parameters (conductance and compliance). In contrast, the thermal degradation products from TDI-based foam did not cause any decrease in lung function. Conclusions Thermal degradation products generated from MDI-based polyurethane foam were more toxic to the lung than those generated from TDI-based polyurethane foam. This difference was probable due to MDI in the particle phase.}}, author = {{Lastbom, L and Colmsjo, A and Johansson, R and Karlsson, Daniel and Melin, J and Nordqvist, Y and Skarping, Gunnar}}, issn = {{0355-3140}}, keywords = {{phenyl isocyanate; mineral wool; aerosol; methyl isocyanate}}, language = {{eng}}, number = {{2}}, pages = {{152--158}}, publisher = {{Finnish Institute of Occupational Health}}, series = {{Scandinavian Journal of Work, Environment and Health}}, title = {{Effects of thermal degradation products from polyurethane foams based on toluene diisocyanate and diphenylmethane diisocyanate on isolated, perfused lung of guinea pig}}, url = {{http://www.sjweh.fi/show_abstract.php?abstract_id=717}}, volume = {{29}}, year = {{2003}}, }