Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridization
(2003) In Acta Histochemica 105(1). p.67-72- Abstract
- Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL), and in minor proportion in triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). The gene coding for apoM has been detected in all mammal genomes. The function of apoM is unknown yet. In the present study, we demonstrated that apoM is exclusively expressed in a strong manner in adult liver and kidney, and is expressed weakly in fetal liver and kidney as detected with human multiple tissue expression array. Both immumohistochemical staining and apoM mRNA in situ hybridization demonstrated that apoM was exclusively expressed in hepatocytes in human liver and in tubular epithelial cells in human... (More)
- Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL), and in minor proportion in triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). The gene coding for apoM has been detected in all mammal genomes. The function of apoM is unknown yet. In the present study, we demonstrated that apoM is exclusively expressed in a strong manner in adult liver and kidney, and is expressed weakly in fetal liver and kidney as detected with human multiple tissue expression array. Both immumohistochemical staining and apoM mRNA in situ hybridization demonstrated that apoM was exclusively expressed in hepatocytes in human liver and in tubular epithelial cells in human kidney. The present study helps to elucidate the pathophysiological functions of apoM in vivo. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/315611
- author
- Zhang, XY ; Dong, X ; Zheng, L ; Luo, GH ; Liu, YH ; Ekström, Ulf LU ; Nilsson-Ehle, Peter LU ; Ye, Q and Xu, Ning LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- in situ hybridization, kidney, liver, apolipoprotein M
- in
- Acta Histochemica
- volume
- 105
- issue
- 1
- pages
- 67 - 72
- publisher
- Elsevier
- external identifiers
-
- wos:000181692500006
- pmid:12666989
- scopus:0037219269
- ISSN
- 0065-1281
- DOI
- 10.1078/0065-1281-00687
- language
- English
- LU publication?
- yes
- id
- 56241ed6-6289-410a-8240-118f1fb98bbf (old id 315611)
- date added to LUP
- 2016-04-01 12:23:45
- date last changed
- 2022-01-27 03:10:51
@article{56241ed6-6289-410a-8240-118f1fb98bbf, abstract = {{Apolipoprotein M (apoM) is a recently discovered human apolipoprotein predominantly present in high-density lipoprotein (HDL), and in minor proportion in triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). The gene coding for apoM has been detected in all mammal genomes. The function of apoM is unknown yet. In the present study, we demonstrated that apoM is exclusively expressed in a strong manner in adult liver and kidney, and is expressed weakly in fetal liver and kidney as detected with human multiple tissue expression array. Both immumohistochemical staining and apoM mRNA in situ hybridization demonstrated that apoM was exclusively expressed in hepatocytes in human liver and in tubular epithelial cells in human kidney. The present study helps to elucidate the pathophysiological functions of apoM in vivo.}}, author = {{Zhang, XY and Dong, X and Zheng, L and Luo, GH and Liu, YH and Ekström, Ulf and Nilsson-Ehle, Peter and Ye, Q and Xu, Ning}}, issn = {{0065-1281}}, keywords = {{in situ hybridization; kidney; liver; apolipoprotein M}}, language = {{eng}}, number = {{1}}, pages = {{67--72}}, publisher = {{Elsevier}}, series = {{Acta Histochemica}}, title = {{Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridization}}, url = {{http://dx.doi.org/10.1078/0065-1281-00687}}, doi = {{10.1078/0065-1281-00687}}, volume = {{105}}, year = {{2003}}, }