Functional and structural change in diabetic eyes. Interim results from an ongoing longitudinal prospective study.
(2013) In Acta Ophthalmologica 91(7). p.672-677- Abstract
- Purpose: To presents results after 18 months of follow-up of a longitudinal study aiming at exploring the correlation between diabetic retinal vascular lesions and functional change. Methods: Patients were consecutively recruited from attendees to the screening program for diabetic retinopathy. Subjects are followed every sixth month for the first 3 years and thereafter annually up to 5 years. Progression of diabetic retinopathy is evaluated using the Early Treatment Diabetic Retinopathy Study (ETDRS) scale and improvement/deterioration in visual fields by predefined significance limits for change. Results: Of 81 subjects, with no/mild/moderate diabetic retinopathy included, 76 have passed the 18-month visit. At that time, retinal... (More)
- Purpose: To presents results after 18 months of follow-up of a longitudinal study aiming at exploring the correlation between diabetic retinal vascular lesions and functional change. Methods: Patients were consecutively recruited from attendees to the screening program for diabetic retinopathy. Subjects are followed every sixth month for the first 3 years and thereafter annually up to 5 years. Progression of diabetic retinopathy is evaluated using the Early Treatment Diabetic Retinopathy Study (ETDRS) scale and improvement/deterioration in visual fields by predefined significance limits for change. Results: Of 81 subjects, with no/mild/moderate diabetic retinopathy included, 76 have passed the 18-month visit. At that time, retinal progression by two steps according to the ETDRS scale had occurred in two subjects. Visual acuity was -0.14 logMAR and had decreased with two letters (0.04 logMAR) (p < 0.001) from baseline. The global visual field index mean deviation was almost unchanged with a negligible improvement of 0.03 dB (p = 0.79). In 21 subjects, repeated significant deterioration was seen in ≥10% of all points tested in the field, while almost no improved points were noted. The two subjects with retinal progression were not among those 21 with indication of perimetric progression. Conclusions: This is, to our knowledge, the first longitudinal study evaluating change of visual fields in a representative diabetic cohort with no or mild/moderate retinopathy. In this interim report, we demonstrate deteriorated perimetric sensitivity in subjects already at 18 months of follow-up. The results will have implications for evaluating change in visual function in future clinical trials. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3161356
- author
- Hellgren, Karl-Johan LU ; Bengtsson, Boel LU and Agardh, Elisabet LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Ophthalmologica
- volume
- 91
- issue
- 7
- pages
- 672 - 677
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000328323000032
- pmid:23025256
- scopus:84885956398
- ISSN
- 1755-3768
- DOI
- 10.1111/j.1755-3768.2012.02508.x
- language
- English
- LU publication?
- yes
- id
- 1b998cbd-54c7-41c2-ae2a-31643d89193d (old id 3161356)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23025256?dopt=Abstract
- date added to LUP
- 2016-04-01 10:43:06
- date last changed
- 2022-04-12 08:59:03
@article{1b998cbd-54c7-41c2-ae2a-31643d89193d, abstract = {{Purpose: To presents results after 18 months of follow-up of a longitudinal study aiming at exploring the correlation between diabetic retinal vascular lesions and functional change. Methods: Patients were consecutively recruited from attendees to the screening program for diabetic retinopathy. Subjects are followed every sixth month for the first 3 years and thereafter annually up to 5 years. Progression of diabetic retinopathy is evaluated using the Early Treatment Diabetic Retinopathy Study (ETDRS) scale and improvement/deterioration in visual fields by predefined significance limits for change. Results: Of 81 subjects, with no/mild/moderate diabetic retinopathy included, 76 have passed the 18-month visit. At that time, retinal progression by two steps according to the ETDRS scale had occurred in two subjects. Visual acuity was -0.14 logMAR and had decreased with two letters (0.04 logMAR) (p < 0.001) from baseline. The global visual field index mean deviation was almost unchanged with a negligible improvement of 0.03 dB (p = 0.79). In 21 subjects, repeated significant deterioration was seen in ≥10% of all points tested in the field, while almost no improved points were noted. The two subjects with retinal progression were not among those 21 with indication of perimetric progression. Conclusions: This is, to our knowledge, the first longitudinal study evaluating change of visual fields in a representative diabetic cohort with no or mild/moderate retinopathy. In this interim report, we demonstrate deteriorated perimetric sensitivity in subjects already at 18 months of follow-up. The results will have implications for evaluating change in visual function in future clinical trials.}}, author = {{Hellgren, Karl-Johan and Bengtsson, Boel and Agardh, Elisabet}}, issn = {{1755-3768}}, language = {{eng}}, number = {{7}}, pages = {{672--677}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Ophthalmologica}}, title = {{Functional and structural change in diabetic eyes. Interim results from an ongoing longitudinal prospective study.}}, url = {{http://dx.doi.org/10.1111/j.1755-3768.2012.02508.x}}, doi = {{10.1111/j.1755-3768.2012.02508.x}}, volume = {{91}}, year = {{2013}}, }