Measurement of MR signal and T2* in lung to characterize a tight skin mouse model of emphysema using single-point imaging
(2007) In Journal of Magnetic Resonance Imaging 25(3). p.94-488- Abstract
PURPOSE: To evaluate whether MRI signal and T2* measurements of lung tissue acquired at ultrashort detection times (tds) can detect emphysematous changes in lungs.
MATERIALS AND METHODS: MR signal intensity of in vivo mouse lungs was measured at 4.7 T at tds of 0.2 and 0.4 msec using single-point imaging (SPI). T2* was calculated from the measurements obtained at the two tds. Two groups of 8- and 30-week-old Tight Skin (TS) and aged-matched CB57BL/6 mice were examined. The TS mice spontaneously developed emphysema-like alveolar enlargement. In vivo micro-computed tomography (microCT) scanning and histology were used as reference methods.
RESULTS: MR signal and T2* were significantly lower in the lungs of TS mice than in... (More)
PURPOSE: To evaluate whether MRI signal and T2* measurements of lung tissue acquired at ultrashort detection times (tds) can detect emphysematous changes in lungs.
MATERIALS AND METHODS: MR signal intensity of in vivo mouse lungs was measured at 4.7 T at tds of 0.2 and 0.4 msec using single-point imaging (SPI). T2* was calculated from the measurements obtained at the two tds. Two groups of 8- and 30-week-old Tight Skin (TS) and aged-matched CB57BL/6 mice were examined. The TS mice spontaneously developed emphysema-like alveolar enlargement. In vivo micro-computed tomography (microCT) scanning and histology were used as reference methods.
RESULTS: MR signal and T2* were significantly lower in the lungs of TS mice than in controls. There were no significant differences between the different age groups. MR signal in lung parenchyma correlated linearly (P < 0.0001, r = 0.89) with microCT mass density, and T2* correlated linearly (P < 0.0001, r = -0.91) with the alveoli size (mean linear intercept [MLI]).
CONCLUSION: The MR signal intensity and T2* measured at short tds can be used as imaging biomarkers to characterize parenchyma density and alveolar size, respectively.
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- author
- Olsson, Lars E LU ; Lindahl, Maria LU ; Onnervik, Per-Ola ; Johansson, Lars B ; Palmér, Malin ; Reimer, Martina Kvist LU ; Hultin, Leif and Hockings, Paul D
- publishing date
- 2007-03
- type
- Contribution to journal
- publication status
- published
- keywords
- Age Factors, Animals, Disease Models, Animal, Disease Progression, Emphysema, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Lung, Magnetic Resonance Imaging, Mice, Signal Processing, Computer-Assisted, Tomography, X-Ray Computed
- in
- Journal of Magnetic Resonance Imaging
- volume
- 25
- issue
- 3
- pages
- 7 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:17279537
- scopus:33847651296
- ISSN
- 1053-1807
- DOI
- 10.1002/jmri.20840
- language
- English
- LU publication?
- no
- id
- 31896240-951f-4139-a1a8-0a54f3b925e5
- date added to LUP
- 2016-08-16 12:11:53
- date last changed
- 2024-05-17 10:29:06
@article{31896240-951f-4139-a1a8-0a54f3b925e5, abstract = {{<p>PURPOSE: To evaluate whether MRI signal and T2* measurements of lung tissue acquired at ultrashort detection times (tds) can detect emphysematous changes in lungs.</p><p>MATERIALS AND METHODS: MR signal intensity of in vivo mouse lungs was measured at 4.7 T at tds of 0.2 and 0.4 msec using single-point imaging (SPI). T2* was calculated from the measurements obtained at the two tds. Two groups of 8- and 30-week-old Tight Skin (TS) and aged-matched CB57BL/6 mice were examined. The TS mice spontaneously developed emphysema-like alveolar enlargement. In vivo micro-computed tomography (microCT) scanning and histology were used as reference methods.</p><p>RESULTS: MR signal and T2* were significantly lower in the lungs of TS mice than in controls. There were no significant differences between the different age groups. MR signal in lung parenchyma correlated linearly (P < 0.0001, r = 0.89) with microCT mass density, and T2* correlated linearly (P < 0.0001, r = -0.91) with the alveoli size (mean linear intercept [MLI]).</p><p>CONCLUSION: The MR signal intensity and T2* measured at short tds can be used as imaging biomarkers to characterize parenchyma density and alveolar size, respectively.</p>}}, author = {{Olsson, Lars E and Lindahl, Maria and Onnervik, Per-Ola and Johansson, Lars B and Palmér, Malin and Reimer, Martina Kvist and Hultin, Leif and Hockings, Paul D}}, issn = {{1053-1807}}, keywords = {{Age Factors; Animals; Disease Models, Animal; Disease Progression; Emphysema; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Lung; Magnetic Resonance Imaging; Mice; Signal Processing, Computer-Assisted; Tomography, X-Ray Computed}}, language = {{eng}}, number = {{3}}, pages = {{94--488}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Journal of Magnetic Resonance Imaging}}, title = {{Measurement of MR signal and T2* in lung to characterize a tight skin mouse model of emphysema using single-point imaging}}, url = {{http://dx.doi.org/10.1002/jmri.20840}}, doi = {{10.1002/jmri.20840}}, volume = {{25}}, year = {{2007}}, }