The Renalase Asp37Glu polymorphism is not associated with hypertension and cardiovascular events in an urban-based prospective cohort: the Malmo Diet and cancer study
Fava, Cristiano LU ; Montagnana, Martina LU ; Danese, Elisa ; Sjögren, Marketa LU ; Almgren, Peter LU ; Engström, Gunnar LU ; Hedblad, Bo LU ; Guidi, Gian Cesare ; Minuz, Pietro and Melander, Olle LU
(2012)
In BMC Medical Genetics
13.
- Abstract
- Background: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies delineate a possible role of this enzyme in blood pressure (BP) maintenance and cardiac protection and two single nucleotide polymorphisms, RNLS rs2576178 A > G and rs2296545 C > G have been associated with hypertension. The latter SNP leads to a non synonymous Asp to Glu substitution deleting a flavin adenine dinucleotide (FAD) binding site with possible impaired functionality. We tested the hypothesis that these polymorphisms could affect BP levels, hypertension prevalence, and risk of incident cardiovascular events in middle-aged Swedes. Methods: The polymorphisms... (More)
- Background: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies delineate a possible role of this enzyme in blood pressure (BP) maintenance and cardiac protection and two single nucleotide polymorphisms, RNLS rs2576178 A > G and rs2296545 C > G have been associated with hypertension. The latter SNP leads to a non synonymous Asp to Glu substitution deleting a flavin adenine dinucleotide (FAD) binding site with possible impaired functionality. We tested the hypothesis that these polymorphisms could affect BP levels, hypertension prevalence, and risk of incident cardiovascular events in middle-aged Swedes. Methods: The polymorphisms were genotyped in 5696 participants of the population-based Cardiovascular Cohort of the "Malmo Diet and Cancer" (MDC-CC). The incidence of cardiovascular events (coronary events [n = 408], strokes [n = 330], heart failure [n = 190] and atrial fibrillation/flutter [n = 406]) was monitored for an average of approximately 15 years of follow-up. Results: Both before and after adjustment for sex, age and BMI the polymorphisms did not show any effect on BP level and hypertension prevalence. Before and after adjustment for major cardiovascular risk factors, the hazard ratio for cardiac and cerebrovascular events was not significantly different in carriers of different genotypes. A significant interaction was found between the rs2296545 C > G and age with respect to BP/hypertension. Conclusions: Our data do not support a major role for these RNLS polymorphisms in determining BP level and incident events at population level. The positive interaction with age suggest that the effect of the rs2296545 C > G polymorphism, if any, could vary between different ages. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3191535
- author
- Fava, Cristiano
LU
; Montagnana, Martina
LU
; Danese, Elisa
; Sjögren, Marketa
LU
; Almgren, Peter
LU
; Engström, Gunnar
LU
; Hedblad, Bo
LU
; Guidi, Gian Cesare
; Minuz, Pietro
and Melander, Olle
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Renalase, Blood pressure, Cardiovascular events, Hypertension, Polymorphisms
- in
- BMC Medical Genetics
- volume
- 13
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000309176700001
- scopus:84866752868
- pmid:22812913
- ISSN
- 1471-2350
- DOI
- 10.1186/1471-2350-13-57
- language
- English
- LU publication?
- yes
- id
- deee5895-0c99-4edc-894c-fe2c49ab63e7 (old id 3191535)
- date added to LUP
- 2016-04-01 13:31:50
- date last changed
- 2024-03-13 10:18:56
@article{deee5895-0c99-4edc-894c-fe2c49ab63e7,
abstract = {{Background: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies delineate a possible role of this enzyme in blood pressure (BP) maintenance and cardiac protection and two single nucleotide polymorphisms, RNLS rs2576178 A > G and rs2296545 C > G have been associated with hypertension. The latter SNP leads to a non synonymous Asp to Glu substitution deleting a flavin adenine dinucleotide (FAD) binding site with possible impaired functionality. We tested the hypothesis that these polymorphisms could affect BP levels, hypertension prevalence, and risk of incident cardiovascular events in middle-aged Swedes. Methods: The polymorphisms were genotyped in 5696 participants of the population-based Cardiovascular Cohort of the "Malmo Diet and Cancer" (MDC-CC). The incidence of cardiovascular events (coronary events [n = 408], strokes [n = 330], heart failure [n = 190] and atrial fibrillation/flutter [n = 406]) was monitored for an average of approximately 15 years of follow-up. Results: Both before and after adjustment for sex, age and BMI the polymorphisms did not show any effect on BP level and hypertension prevalence. Before and after adjustment for major cardiovascular risk factors, the hazard ratio for cardiac and cerebrovascular events was not significantly different in carriers of different genotypes. A significant interaction was found between the rs2296545 C > G and age with respect to BP/hypertension. Conclusions: Our data do not support a major role for these RNLS polymorphisms in determining BP level and incident events at population level. The positive interaction with age suggest that the effect of the rs2296545 C > G polymorphism, if any, could vary between different ages.}},
author = {{Fava, Cristiano and Montagnana, Martina and Danese, Elisa and Sjögren, Marketa and Almgren, Peter and Engström, Gunnar and Hedblad, Bo and Guidi, Gian Cesare and Minuz, Pietro and Melander, Olle}},
issn = {{1471-2350}},
keywords = {{Renalase; Blood pressure; Cardiovascular events; Hypertension; Polymorphisms}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Medical Genetics}},
title = {{The Renalase Asp37Glu polymorphism is not associated with hypertension and cardiovascular events in an urban-based prospective cohort: the Malmo Diet and cancer study}},
url = {{https://lup.lub.lu.se/search/files/3432079/3629594.pdf}},
doi = {{10.1186/1471-2350-13-57}},
volume = {{13}},
year = {{2012}},
}