Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis
(2003) In Journal of American Academy of Dermatology 48(1). p.48-54- Abstract
- Background: Calcipotriene and betamethasone dipropionate are topical treatments for psoriasis vulgaris. Their mode of action is different. Improved risk/benefit may result with concomitant use of the two compounds together. A new vehicle has been created with the objective of obtaining optimal stability of both calcipotriene and betamethasone dipropionate in the combination product. Objective. We compared the clinical efficacy of a fixed combination of calcipotriene and betamethasone clipropionate in a new vehicle to calcipotriene in the new vehicle, betamethasone in the new vehicle, and the new vehicle alone. Methods: This was an international, multicenter, prospective, randomized, double-blind, parallel-group, 4-week study in patients... (More)
- Background: Calcipotriene and betamethasone dipropionate are topical treatments for psoriasis vulgaris. Their mode of action is different. Improved risk/benefit may result with concomitant use of the two compounds together. A new vehicle has been created with the objective of obtaining optimal stability of both calcipotriene and betamethasone dipropionate in the combination product. Objective. We compared the clinical efficacy of a fixed combination of calcipotriene and betamethasone clipropionate in a new vehicle to calcipotriene in the new vehicle, betamethasone in the new vehicle, and the new vehicle alone. Methods: This was an international, multicenter, prospective, randomized, double-blind, parallel-group, 4-week study in patients with psoriasis vulgaris amenable to topical treatment. Results. The mean percentage reduction in PASI from baseline to end of treatment was 73.2% in the combination group (n = 301), 48.8% in the calcipotriene group (n = 308), 63.1% in the betamethasone dipropionate group (n = 312) and 28.8% in the new vehicle group (n = 107), (P < .001). The mean percentage reduction in PASI during the first week was 48.1%, 28.4%, 41.4%, and 21.5%, respectively (P < .001). Conclusion: A combination product of calcipotriene 50 mug/g and betamethasone dipropionate 0.5 mg/g in the new vehicle shows superior efficacy with a more rapid onset of action than the new vehicle containing either constituent alone in the treatment of psoriasis vulgaris. (Less)
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https://lup.lub.lu.se/record/319766
- author
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of American Academy of Dermatology
- volume
- 48
- issue
- 1
- pages
- 48 - 54
- publisher
- Elsevier
- external identifiers
-
- pmid:12522370
- wos:000180348600006
- scopus:0037231470
- pmid:12522370
- ISSN
- 0190-9622
- DOI
- 10.1067/mjd.2003.130
- language
- English
- LU publication?
- yes
- id
- 3d422e95-a465-462a-8b22-d7134223c5ee (old id 319766)
- date added to LUP
- 2016-04-01 12:19:05
- date last changed
- 2022-03-28 23:18:46
@article{3d422e95-a465-462a-8b22-d7134223c5ee, abstract = {{Background: Calcipotriene and betamethasone dipropionate are topical treatments for psoriasis vulgaris. Their mode of action is different. Improved risk/benefit may result with concomitant use of the two compounds together. A new vehicle has been created with the objective of obtaining optimal stability of both calcipotriene and betamethasone dipropionate in the combination product. Objective. We compared the clinical efficacy of a fixed combination of calcipotriene and betamethasone clipropionate in a new vehicle to calcipotriene in the new vehicle, betamethasone in the new vehicle, and the new vehicle alone. Methods: This was an international, multicenter, prospective, randomized, double-blind, parallel-group, 4-week study in patients with psoriasis vulgaris amenable to topical treatment. Results. The mean percentage reduction in PASI from baseline to end of treatment was 73.2% in the combination group (n = 301), 48.8% in the calcipotriene group (n = 308), 63.1% in the betamethasone dipropionate group (n = 312) and 28.8% in the new vehicle group (n = 107), (P < .001). The mean percentage reduction in PASI during the first week was 48.1%, 28.4%, 41.4%, and 21.5%, respectively (P < .001). Conclusion: A combination product of calcipotriene 50 mug/g and betamethasone dipropionate 0.5 mg/g in the new vehicle shows superior efficacy with a more rapid onset of action than the new vehicle containing either constituent alone in the treatment of psoriasis vulgaris.}}, author = {{Papp, KA and Guenther, L and Boyden, B and Larsen, FG and Harvima, RJ and Guilhou, JJ and Kaufmann, R and Rogers, S and van de Kerkhof, PCM and Hanssen, LI and Tegner, Eva and Burg, G and Talbot, D and Chu, A}}, issn = {{0190-9622}}, language = {{eng}}, number = {{1}}, pages = {{48--54}}, publisher = {{Elsevier}}, series = {{Journal of American Academy of Dermatology}}, title = {{Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis}}, url = {{http://dx.doi.org/10.1067/mjd.2003.130}}, doi = {{10.1067/mjd.2003.130}}, volume = {{48}}, year = {{2003}}, }