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Diagnosis of multiple sclerosis subtype through machine learning analysis of frontal cortex metabolite profiles

Kurada, Abhinav V ; Swanberg, Kelley M. LU orcid ; Prinsen, Hetty and Juchem, Christoph (2019) 2019.
Abstract
The onset and progression of multiple sclerosis (MS) is accompanied by changes in brain biochemistry. Magnetic resonance spectroscopy (MRS) is a powerful tool for investigating these changes in vivo. Machine learning analysis of MRS-derived biochemical profiles may reveal metabolic patterns inherent in certain MS subtypes to inform their diagnosis. By employing a feature set of only metabolite concentrations derived from brain MRS data acquired at 7 Tesla, we achieved an 80% validation set accuracy for differentiating MS patients from healthy controls and a 70% validation set accuracy for differentiating relapsing-remitting and progressive MS patients.
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author
; ; and
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
host publication
Proc Int Soc Magn Reson Med
volume
2019
language
English
LU publication?
no
id
321b3fc6-cf02-4220-bdbc-b48e2f94dcd3
date added to LUP
2023-09-18 15:51:06
date last changed
2024-08-07 09:45:04
@inproceedings{321b3fc6-cf02-4220-bdbc-b48e2f94dcd3,
  abstract     = {{The onset and progression of multiple sclerosis (MS) is accompanied by changes in brain biochemistry. Magnetic resonance spectroscopy (MRS) is a powerful tool for investigating these changes in vivo. Machine learning analysis of MRS-derived biochemical profiles may reveal metabolic patterns inherent in certain MS subtypes to inform their diagnosis. By employing a feature set of only metabolite concentrations derived from brain MRS data acquired at 7 Tesla, we achieved an 80% validation set accuracy for differentiating MS patients from healthy controls and a 70% validation set accuracy for differentiating relapsing-remitting and progressive MS patients.}},
  author       = {{Kurada, Abhinav V and Swanberg, Kelley M. and Prinsen, Hetty and Juchem, Christoph}},
  booktitle    = {{Proc Int Soc Magn Reson Med}},
  language     = {{eng}},
  title        = {{Diagnosis of multiple sclerosis subtype through machine learning analysis of frontal cortex metabolite profiles}},
  volume       = {{2019}},
  year         = {{2019}},
}