Calcium in Cell-Extracellular Matrix Interactions
(2020) In Advances in Experimental Medicine and Biology 1131. p.1079-1102- Abstract
In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/32424632-3195-4db7-bfe7-34e4387e38c4
- author
- Gopal, Sandeep LU ; Multhaupt, Hinke A B and Couchman, John R
- publishing date
- 2020
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Animals, Calcium/metabolism, Cell Movement, Extracellular Matrix/metabolism, Extracellular Matrix Proteins/metabolism
- host publication
- Calcium signaling
- series title
- Advances in Experimental Medicine and Biology
- editor
- Islam, Md Shahidul
- volume
- 1131
- edition
- 2
- pages
- 24 pages
- publisher
- Springer Nature
- external identifiers
-
- scopus:85074084646
- pmid:31646546
- ISSN
- 0065-2598
- ISBN
- 9783030124571
- DOI
- 10.1007/978-3-030-12457-1_43
- language
- English
- LU publication?
- no
- id
- 32424632-3195-4db7-bfe7-34e4387e38c4
- date added to LUP
- 2021-10-25 13:04:26
- date last changed
- 2024-08-10 23:44:01
@inbook{32424632-3195-4db7-bfe7-34e4387e38c4, abstract = {{<p>In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.</p>}}, author = {{Gopal, Sandeep and Multhaupt, Hinke A B and Couchman, John R}}, booktitle = {{Calcium signaling}}, editor = {{Islam, Md Shahidul}}, isbn = {{9783030124571}}, issn = {{0065-2598}}, keywords = {{Animals; Calcium/metabolism; Cell Movement; Extracellular Matrix/metabolism; Extracellular Matrix Proteins/metabolism}}, language = {{eng}}, pages = {{1079--1102}}, publisher = {{Springer Nature}}, series = {{Advances in Experimental Medicine and Biology}}, title = {{Calcium in Cell-Extracellular Matrix Interactions}}, url = {{http://dx.doi.org/10.1007/978-3-030-12457-1_43}}, doi = {{10.1007/978-3-030-12457-1_43}}, volume = {{1131}}, year = {{2020}}, }