Allergy to methyltetrahydrophthalic anhydride in epoxy resin workers
(1992) In British Journal of Industrial Medicine 49(11). p.769-775- Abstract
- One hundred and forty four current and 26
former workers in a plant producing barrels
for rocket guns from an epoxy resin containing
methyltetrahydrophthalic anhydride
(MTHPA; time weighted average air concentration
up to 150 uglm') were studied. They
showed higher frequencies of work related
symptoms from the eyes (31 v 0%; p < 0-001),
nose (53 v 9%; p < 0-001), pharynx (26 v 6%;
p < 0-01), and asthma (11 v 0%; p < 0 05) than
33 controls. Also they had higher rates of
positive skin prick test to a conjugate of
MTHPA and human serum albumin (16 v 0%;
p < 0-01), and more had specific IgE and IgG
serum... (More) - One hundred and forty four current and 26
former workers in a plant producing barrels
for rocket guns from an epoxy resin containing
methyltetrahydrophthalic anhydride
(MTHPA; time weighted average air concentration
up to 150 uglm') were studied. They
showed higher frequencies of work related
symptoms from the eyes (31 v 0%; p < 0-001),
nose (53 v 9%; p < 0-001), pharynx (26 v 6%;
p < 0-01), and asthma (11 v 0%; p < 0 05) than
33 controls. Also they had higher rates of
positive skin prick test to a conjugate of
MTHPA and human serum albumin (16 v 0%;
p < 0-01), and more had specific IgE and IgG
serum antibodies (18 v 0%; p < 0-01 and 12 v
0%; p < 0 05 respectively). There were statistically
significant exposure-response relations
between exposure and symptoms from eyes
and upper airways, dry cough, positive skin
prick test, and specific IgE and IgG antibodies.
There was a non-significant difference in reaction
to metacholine between exposed workers
and non-smoking controls. In workers with
and without specific IgE antibodies, differences
existed in frequency of nasal secretion (54 v
23%; p < 0-05) and dry cough (38 v 12%;
p < 0-05). Workers with specific IgG had more
dry cough (38 v 12%; p < 0-05), but less symptoms
ofnon-specific bronchial hyperreactivity
(0 v 26%; p < 0-05). Atopic workers sneezed
more than non-atopic workers (65 v 30%;
p < 0-01). In a prospective study five sensitised
workers who left the factory became less reactive
to metacholine, and became symptom
free. In 41 workers who stayed, there was no
improvement, despite a 10-fold reduction in
exposure. The results show the extreme sensitising
properties ofMTHPA. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3294508
- author
- Nielsen, Jörn LU ; Welinder, Hans LU ; Horstmann, Vibeke LU and Skerfving, Staffan LU
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Industrial Medicine
- volume
- 49
- issue
- 11
- pages
- 769 - 775
- publisher
- BMJ Publishing Group
- external identifiers
-
- scopus:0026460835
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Occupational Therapy (Closed 2012) (013025000), Division of Occupational and Environmental Medicine (013078001)
- id
- 7c5d2b6c-ceca-42c7-8e8c-9c4c81936cfd (old id 3294508)
- alternative location
- http://www.jstor.org/stable/27727526
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1039324/
- http://www.ncbi.nlm.nih.gov/pubmed/1463677
- date added to LUP
- 2016-04-04 14:28:27
- date last changed
- 2021-01-03 11:06:50
@article{7c5d2b6c-ceca-42c7-8e8c-9c4c81936cfd,
abstract = {{One hundred and forty four current and 26<br/><br>
former workers in a plant producing barrels<br/><br>
for rocket guns from an epoxy resin containing<br/><br>
methyltetrahydrophthalic anhydride<br/><br>
(MTHPA; time weighted average air concentration<br/><br>
up to 150 uglm') were studied. They<br/><br>
showed higher frequencies of work related<br/><br>
symptoms from the eyes (31 v 0%; p < 0-001),<br/><br>
nose (53 v 9%; p < 0-001), pharynx (26 v 6%;<br/><br>
p < 0-01), and asthma (11 v 0%; p < 0 05) than<br/><br>
33 controls. Also they had higher rates of<br/><br>
positive skin prick test to a conjugate of<br/><br>
MTHPA and human serum albumin (16 v 0%;<br/><br>
p < 0-01), and more had specific IgE and IgG<br/><br>
serum antibodies (18 v 0%; p < 0-01 and 12 v<br/><br>
0%; p < 0 05 respectively). There were statistically<br/><br>
significant exposure-response relations<br/><br>
between exposure and symptoms from eyes<br/><br>
and upper airways, dry cough, positive skin<br/><br>
prick test, and specific IgE and IgG antibodies.<br/><br>
There was a non-significant difference in reaction<br/><br>
to metacholine between exposed workers<br/><br>
and non-smoking controls. In workers with<br/><br>
and without specific IgE antibodies, differences<br/><br>
existed in frequency of nasal secretion (54 v<br/><br>
23%; p < 0-05) and dry cough (38 v 12%;<br/><br>
p < 0-05). Workers with specific IgG had more<br/><br>
dry cough (38 v 12%; p < 0-05), but less symptoms<br/><br>
ofnon-specific bronchial hyperreactivity<br/><br>
(0 v 26%; p < 0-05). Atopic workers sneezed<br/><br>
more than non-atopic workers (65 v 30%;<br/><br>
p < 0-01). In a prospective study five sensitised<br/><br>
workers who left the factory became less reactive<br/><br>
to metacholine, and became symptom<br/><br>
free. In 41 workers who stayed, there was no<br/><br>
improvement, despite a 10-fold reduction in<br/><br>
exposure. The results show the extreme sensitising<br/><br>
properties ofMTHPA.}},
author = {{Nielsen, Jörn and Welinder, Hans and Horstmann, Vibeke and Skerfving, Staffan}},
language = {{eng}},
number = {{11}},
pages = {{769--775}},
publisher = {{BMJ Publishing Group}},
series = {{British Journal of Industrial Medicine}},
title = {{Allergy to methyltetrahydrophthalic anhydride in epoxy resin workers}},
url = {{http://www.jstor.org/stable/27727526}},
volume = {{49}},
year = {{1992}},
}