Chronic hyperbaric exposure activates proinflammatory mediators in humans
(2002) In Journal of Applied Physiology 92(6). p.2375-2380- Abstract
- Decompression illness (DCI) is an illness affecting divers subjected to reductions in ambient pressure. Besides a mechanical explanation to DCI, an inflammatory mechanism has been suggested. In this study, levels of interleukin (IL)-8, IL-6, IL-1 receptor antagonist (IL-1ra), secretory leukocyte protease inhibitor (SLPI), and neutrophil gelatinase-associated lipocalcin (NGAL) were measured in divers before and after a 2-mo period of daily diving. The divers were military conscripts and completed their diving period with no clinical symptoms of DCI. We found no change in IL-6 and IL1-ra but did find an increase in IL-8 and NGAL together with a decrease in SLPI levels. The findings suggest an inflammatory activation. This activation is not... (More)
- Decompression illness (DCI) is an illness affecting divers subjected to reductions in ambient pressure. Besides a mechanical explanation to DCI, an inflammatory mechanism has been suggested. In this study, levels of interleukin (IL)-8, IL-6, IL-1 receptor antagonist (IL-1ra), secretory leukocyte protease inhibitor (SLPI), and neutrophil gelatinase-associated lipocalcin (NGAL) were measured in divers before and after a 2-mo period of daily diving. The divers were military conscripts and completed their diving period with no clinical symptoms of DCI. We found no change in IL-6 and IL1-ra but did find an increase in IL-8 and NGAL together with a decrease in SLPI levels. The findings suggest an inflammatory activation. This activation is not severe because no changes in IL-6 or IL-1ra were found. The increase in NGAL and IL-8 levels were interpreted as a sign of leukocyte activation. The decreased SLPI levels suggest an influence on the inflammatory defense mechanism. All in all, the findings of this study show a compensated activation of the inflammatory defense mechanism without loss of homeostasis of the inflammatory system. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/337183
- author
- Ersson, Anders LU ; Walles, Maria LU ; Ohlsson, K and Ekholm, A
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- decompression, diving, inflammatory activation
- in
- Journal of Applied Physiology
- volume
- 92
- issue
- 6
- pages
- 2375 - 2380
- publisher
- American Physiological Society
- external identifiers
-
- pmid:12015350
- wos:000175739200020
- scopus:0036082172
- ISSN
- 1522-1601
- DOI
- 10.1152/japplphysiol.00705.2001
- language
- English
- LU publication?
- yes
- id
- 4dce52fd-babb-40ae-b02d-557ea3285744 (old id 337183)
- date added to LUP
- 2016-04-01 12:30:09
- date last changed
- 2022-04-21 08:16:10
@article{4dce52fd-babb-40ae-b02d-557ea3285744,
abstract = {{Decompression illness (DCI) is an illness affecting divers subjected to reductions in ambient pressure. Besides a mechanical explanation to DCI, an inflammatory mechanism has been suggested. In this study, levels of interleukin (IL)-8, IL-6, IL-1 receptor antagonist (IL-1ra), secretory leukocyte protease inhibitor (SLPI), and neutrophil gelatinase-associated lipocalcin (NGAL) were measured in divers before and after a 2-mo period of daily diving. The divers were military conscripts and completed their diving period with no clinical symptoms of DCI. We found no change in IL-6 and IL1-ra but did find an increase in IL-8 and NGAL together with a decrease in SLPI levels. The findings suggest an inflammatory activation. This activation is not severe because no changes in IL-6 or IL-1ra were found. The increase in NGAL and IL-8 levels were interpreted as a sign of leukocyte activation. The decreased SLPI levels suggest an influence on the inflammatory defense mechanism. All in all, the findings of this study show a compensated activation of the inflammatory defense mechanism without loss of homeostasis of the inflammatory system.}},
author = {{Ersson, Anders and Walles, Maria and Ohlsson, K and Ekholm, A}},
issn = {{1522-1601}},
keywords = {{decompression; diving; inflammatory activation}},
language = {{eng}},
number = {{6}},
pages = {{2375--2380}},
publisher = {{American Physiological Society}},
series = {{Journal of Applied Physiology}},
title = {{Chronic hyperbaric exposure activates proinflammatory mediators in humans}},
url = {{http://dx.doi.org/10.1152/japplphysiol.00705.2001}},
doi = {{10.1152/japplphysiol.00705.2001}},
volume = {{92}},
year = {{2002}},
}