5 ' flanking variants of resistin are associated with obesity
(2002) In Diabetes 51(5). p.1629-1634- Abstract
- Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated... (More)
- Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated with an increase in BMI (P = 0.03 and P = 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95% Cl 1.28-5.81) and the g.-420 variants (1.58, 1.06-2.35) were associated with an increased risk for a BMI greater than or equal to30 kg/m(2). In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples. (Less)
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https://lup.lub.lu.se/record/338383
- author
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes
- volume
- 51
- issue
- 5
- pages
- 1629 - 1634
- publisher
- American Diabetes Association Inc.
- external identifiers
-
- wos:000175492400042
- pmid:11978666
- scopus:0036020829
- ISSN
- 1939-327X
- DOI
- 10.2337/diabetes.51.5.1629
- language
- English
- LU publication?
- yes
- id
- 1be98e7d-01d0-40eb-870e-793f2bfda379 (old id 338383)
- date added to LUP
- 2016-04-01 15:51:06
- date last changed
- 2024-03-28 11:53:19
@article{1be98e7d-01d0-40eb-870e-793f2bfda379,
abstract = {{Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated with an increase in BMI (P = 0.03 and P = 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95% Cl 1.28-5.81) and the g.-420 variants (1.58, 1.06-2.35) were associated with an increased risk for a BMI greater than or equal to30 kg/m(2). In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples.}},
author = {{Engert, JC and Vohl, MC and Williams, SM and Lepage, P and Loredo-Osti, JC and Faith, J and Dore, C and Renaud, Y and Burtt, NP and Villeneuve, A and Hirschhorn, JN and Altshuler, D and Groop, Leif and Despres, JP and Gaudet, D and Hudson, TJ}},
issn = {{1939-327X}},
language = {{eng}},
number = {{5}},
pages = {{1629--1634}},
publisher = {{American Diabetes Association Inc.}},
series = {{Diabetes}},
title = {{5 ' flanking variants of resistin are associated with obesity}},
url = {{http://dx.doi.org/10.2337/diabetes.51.5.1629}},
doi = {{10.2337/diabetes.51.5.1629}},
volume = {{51}},
year = {{2002}},
}