Mechanistic modelling of drug release from a polymer matrix using magnetic resonance microimaging.
(2013) In European Journal of Pharmaceutical Sciences 48(4-5). p.698-708- Abstract
- In this paper a new model describing drug release from a polymer matrix tablet is presented. The utilization of the model is described as a two step process where, initially, polymer parameters are obtained from a previously published pure polymer dissolution model. The results are then combined with drug parameters obtained from literature data in the new model to predict solvent and drug concentration profiles and polymer and drug release profiles. The modelling approach was applied to the case of a HPMC matrix highly loaded with mannitol (model drug). The results showed that the drug release rate can be successfully predicted, using the suggested modelling approach. However, the model was not able to accurately predict the polymer... (More)
- In this paper a new model describing drug release from a polymer matrix tablet is presented. The utilization of the model is described as a two step process where, initially, polymer parameters are obtained from a previously published pure polymer dissolution model. The results are then combined with drug parameters obtained from literature data in the new model to predict solvent and drug concentration profiles and polymer and drug release profiles. The modelling approach was applied to the case of a HPMC matrix highly loaded with mannitol (model drug). The results showed that the drug release rate can be successfully predicted, using the suggested modelling approach. However, the model was not able to accurately predict the polymer release profile, possibly due to the sparse amount of usable pure polymer dissolution data. In addition to the case study, a sensitivity analysis of model parameters relevant to drug release was performed. The analysis revealed important information that can be useful in the drug formulation process. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3438931
- author
- Kaunisto, Erik LU ; Tajarobi, Farhad ; Abrahmsen-Alami, Susanna ; Larsson, Anette ; Nilsson, Bernt LU and Axelsson, Anders LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Pharmaceutical Sciences
- volume
- 48
- issue
- 4-5
- pages
- 698 - 708
- publisher
- Elsevier
- external identifiers
-
- wos:000317087300013
- pmid:23298576
- scopus:84873451299
- pmid:23298576
- ISSN
- 1879-0720
- DOI
- 10.1016/j.ejps.2012.12.030
- language
- English
- LU publication?
- yes
- id
- 40ae278f-1b07-4a45-adb2-be42e72c0bc2 (old id 3438931)
- date added to LUP
- 2016-04-01 10:21:25
- date last changed
- 2023-08-31 00:38:21
@article{40ae278f-1b07-4a45-adb2-be42e72c0bc2,
abstract = {{In this paper a new model describing drug release from a polymer matrix tablet is presented. The utilization of the model is described as a two step process where, initially, polymer parameters are obtained from a previously published pure polymer dissolution model. The results are then combined with drug parameters obtained from literature data in the new model to predict solvent and drug concentration profiles and polymer and drug release profiles. The modelling approach was applied to the case of a HPMC matrix highly loaded with mannitol (model drug). The results showed that the drug release rate can be successfully predicted, using the suggested modelling approach. However, the model was not able to accurately predict the polymer release profile, possibly due to the sparse amount of usable pure polymer dissolution data. In addition to the case study, a sensitivity analysis of model parameters relevant to drug release was performed. The analysis revealed important information that can be useful in the drug formulation process.}},
author = {{Kaunisto, Erik and Tajarobi, Farhad and Abrahmsen-Alami, Susanna and Larsson, Anette and Nilsson, Bernt and Axelsson, Anders}},
issn = {{1879-0720}},
language = {{eng}},
number = {{4-5}},
pages = {{698--708}},
publisher = {{Elsevier}},
series = {{European Journal of Pharmaceutical Sciences}},
title = {{Mechanistic modelling of drug release from a polymer matrix using magnetic resonance microimaging.}},
url = {{http://dx.doi.org/10.1016/j.ejps.2012.12.030}},
doi = {{10.1016/j.ejps.2012.12.030}},
volume = {{48}},
year = {{2013}},
}