Autologous chondrocyte transplantation - Biomechanics and long-term durability
(2002) In The American journal of sports medicine 30(1). p.2-12- Abstract
- We evaluated the durability of autologous chondrocyte transplantation grafts in 61 patients treated for isolated cartilage defects on the femoral condyle or the patella and followed up for a mean of 7.4 years (range, 5 to 11). Durability was determined by comparing the clinical status at the long-term follow-up with that found 2 years after the transplantation. After 2 years, 50 of the 61 patients had good or excellent clinical results, and 51 of 61 had good or excellent results at 5 to 11 years later. Grafted areas from 11 of the patients were evaluated with an electromechanical indentation probe during a second-look arthroscopy procedure (mean follow-up, 54.3 months; range, 33 to 84); stiffness measurements were 90% or more of those of... (More)
- We evaluated the durability of autologous chondrocyte transplantation grafts in 61 patients treated for isolated cartilage defects on the femoral condyle or the patella and followed up for a mean of 7.4 years (range, 5 to 11). Durability was determined by comparing the clinical status at the long-term follow-up with that found 2 years after the transplantation. After 2 years, 50 of the 61 patients had good or excellent clinical results, and 51 of 61 had good or excellent results at 5 to 11 years later. Grafted areas from 11 of the patients were evaluated with an electromechanical indentation probe during a second-look arthroscopy procedure (mean follow-up, 54.3 months; range, 33 to 84); stiffness measurements were 90% or more of those of normal cartilage in eight patients. Eight of twelve 2-mm biopsy samples taken from these patients showed hyaline characteristics with safranin O staining and a homogeneous appearance in polarized light. Three fibrous and eight hyaline biopsy specimens stained positive to aggrecan and to cartilage oligomeric matrix protein. Hyaline-like specimens stained positive for type II collagen, and fibrous, for type I Collagen. Autologous chondrocyte transplantation for the treatment of articular cartilage injuries has a durable outcome for as long as 11 years. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/344612
- author
- Peterson, L ; Brittberg, M ; Kiviranta, I ; Lundgren-Åkerlund, Evy LU and Lindahl, A
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- The American journal of sports medicine
- volume
- 30
- issue
- 1
- pages
- 2 - 12
- publisher
- SAGE Publications
- external identifiers
-
- wos:000173349800002
- scopus:0036155852
- ISSN
- 1552-3365
- language
- English
- LU publication?
- yes
- id
- 15c6cf90-cda6-4c22-9774-d7f077e0b1ae (old id 344612)
- alternative location
- http://ajs.sagepub.com/cgi/content/abstract/30/1/2
- date added to LUP
- 2016-04-01 17:15:27
- date last changed
- 2022-04-23 03:31:01
@article{15c6cf90-cda6-4c22-9774-d7f077e0b1ae,
abstract = {{We evaluated the durability of autologous chondrocyte transplantation grafts in 61 patients treated for isolated cartilage defects on the femoral condyle or the patella and followed up for a mean of 7.4 years (range, 5 to 11). Durability was determined by comparing the clinical status at the long-term follow-up with that found 2 years after the transplantation. After 2 years, 50 of the 61 patients had good or excellent clinical results, and 51 of 61 had good or excellent results at 5 to 11 years later. Grafted areas from 11 of the patients were evaluated with an electromechanical indentation probe during a second-look arthroscopy procedure (mean follow-up, 54.3 months; range, 33 to 84); stiffness measurements were 90% or more of those of normal cartilage in eight patients. Eight of twelve 2-mm biopsy samples taken from these patients showed hyaline characteristics with safranin O staining and a homogeneous appearance in polarized light. Three fibrous and eight hyaline biopsy specimens stained positive to aggrecan and to cartilage oligomeric matrix protein. Hyaline-like specimens stained positive for type II collagen, and fibrous, for type I Collagen. Autologous chondrocyte transplantation for the treatment of articular cartilage injuries has a durable outcome for as long as 11 years.}},
author = {{Peterson, L and Brittberg, M and Kiviranta, I and Lundgren-Åkerlund, Evy and Lindahl, A}},
issn = {{1552-3365}},
language = {{eng}},
number = {{1}},
pages = {{2--12}},
publisher = {{SAGE Publications}},
series = {{The American journal of sports medicine}},
title = {{Autologous chondrocyte transplantation - Biomechanics and long-term durability}},
url = {{http://ajs.sagepub.com/cgi/content/abstract/30/1/2}},
volume = {{30}},
year = {{2002}},
}