Nanomodified surfaces and neurite outgrowth
(2011) In Progress in Brain Research 194. p.253-262- Abstract
- Here we describe our attempts to study the interaction of nanomodified surfaces with neurons and macrophages. Surfaces with nano-sized topographies produced by UV lithography, electrochemical etching, nanoimprint lithography, microdispensing, or by electrospinning of plastic nanofibers or by making plastic replicas of the extracellular matrix with nanoresolution were found to guide neurite outgrowth extending from the dorsal root and the superior cervical ganglion in tissue culture. Ordered arrays of nanowires acted as particularly potent guides for the neurites. Loose nanowires activated the macrophages. We conclude that relatively simple nanomodifications of surfaces can be utilized to guide neurites. This property could potentially be... (More)
- Here we describe our attempts to study the interaction of nanomodified surfaces with neurons and macrophages. Surfaces with nano-sized topographies produced by UV lithography, electrochemical etching, nanoimprint lithography, microdispensing, or by electrospinning of plastic nanofibers or by making plastic replicas of the extracellular matrix with nanoresolution were found to guide neurite outgrowth extending from the dorsal root and the superior cervical ganglion in tissue culture. Ordered arrays of nanowires acted as particularly potent guides for the neurites. Loose nanowires activated the macrophages. We conclude that relatively simple nanomodifications of surfaces can be utilized to guide neurites. This property could potentially be applied to guide neurite outgrowth on implants in the nervous system intended for recordings of electrical and/or chemical activities. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3470369
- author
- Kanje, Martin LU and Johansson, Fredrik LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- nanostructured materials, nerve regeneration, ganglia DRG, neurite, electrodes, implants
- in
- Progress in Brain Research
- volume
- 194
- pages
- 253 - 262
- publisher
- Elsevier
- external identifiers
-
- wos:000311038900020
- scopus:80051873976
- pmid:21867809
- ISSN
- 1875-7855
- DOI
- 10.1016/B978-0-444-53815-4.00002-9
- language
- English
- LU publication?
- yes
- id
- dd1224f2-bc36-4e8e-bc23-7ba4a54c24aa (old id 3470369)
- date added to LUP
- 2016-04-01 13:41:21
- date last changed
- 2022-03-14 01:20:43
@article{dd1224f2-bc36-4e8e-bc23-7ba4a54c24aa, abstract = {{Here we describe our attempts to study the interaction of nanomodified surfaces with neurons and macrophages. Surfaces with nano-sized topographies produced by UV lithography, electrochemical etching, nanoimprint lithography, microdispensing, or by electrospinning of plastic nanofibers or by making plastic replicas of the extracellular matrix with nanoresolution were found to guide neurite outgrowth extending from the dorsal root and the superior cervical ganglion in tissue culture. Ordered arrays of nanowires acted as particularly potent guides for the neurites. Loose nanowires activated the macrophages. We conclude that relatively simple nanomodifications of surfaces can be utilized to guide neurites. This property could potentially be applied to guide neurite outgrowth on implants in the nervous system intended for recordings of electrical and/or chemical activities.}}, author = {{Kanje, Martin and Johansson, Fredrik}}, issn = {{1875-7855}}, keywords = {{nanostructured materials; nerve regeneration; ganglia DRG; neurite; electrodes; implants}}, language = {{eng}}, pages = {{253--262}}, publisher = {{Elsevier}}, series = {{Progress in Brain Research}}, title = {{Nanomodified surfaces and neurite outgrowth}}, url = {{http://dx.doi.org/10.1016/B978-0-444-53815-4.00002-9}}, doi = {{10.1016/B978-0-444-53815-4.00002-9}}, volume = {{194}}, year = {{2011}}, }