Nucleolar proteins with altered expression in leukemic cell lines.
(2012) In Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 36(2). p.232-236- Abstract
- The function of the nucleolus is intimately connected to cell proliferation, division and growth. Many cancer cells have enlarged nucleoli, and several nucleolar proteins have been linked to tumorigenesis. In order to find proteins whose expression is altered in the nucleoli of leukemic cells, we carried out two-dimensional difference gel electrophoresis (2-D DIGE) analyses. Prohibitin (PHB) and TAR-DNA-binding protein-43 (TDP-43) were strongly expressed in the nucleoli of the pre-B-ALL cell line MHH-CALL3. Our results demonstrate that leukemic cells have differences in their nucleolar protein composition, and suggest that it may be possible to exploit these differences in identification of leukemia subtypes.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3634639
- author
- Teittinen, Kaisa J ; Kärkkäinen, Pauliina ; Salonen, Johanna ; Rönnholm, Gunilla ; Korkeamäki, Hanna ; Vihinen, Mauno LU ; Kalkkinen, Nisse and Lohi, Olli
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Repressor Proteins: metabolism, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: metabolism, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: diagnosis, Nuclear Proteins: metabolism, Cell Nucleolus: metabolism, DNA-Binding Proteins: metabolism, Tumor Markers, Biological: metabolism
- in
- Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
- volume
- 36
- issue
- 2
- pages
- 232 - 236
- publisher
- Elsevier
- external identifiers
-
- pmid:21783252
- scopus:84855194324
- ISSN
- 1873-5835
- DOI
- 10.1016/j.leukres.2011.06.038
- language
- English
- LU publication?
- no
- id
- b8afcc29-3609-41b6-877f-09d899d16f09 (old id 3634639)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21783252?dopt=Abstract
- date added to LUP
- 2016-04-04 08:41:40
- date last changed
- 2022-02-20 22:06:55
@article{b8afcc29-3609-41b6-877f-09d899d16f09, abstract = {{The function of the nucleolus is intimately connected to cell proliferation, division and growth. Many cancer cells have enlarged nucleoli, and several nucleolar proteins have been linked to tumorigenesis. In order to find proteins whose expression is altered in the nucleoli of leukemic cells, we carried out two-dimensional difference gel electrophoresis (2-D DIGE) analyses. Prohibitin (PHB) and TAR-DNA-binding protein-43 (TDP-43) were strongly expressed in the nucleoli of the pre-B-ALL cell line MHH-CALL3. Our results demonstrate that leukemic cells have differences in their nucleolar protein composition, and suggest that it may be possible to exploit these differences in identification of leukemia subtypes.}}, author = {{Teittinen, Kaisa J and Kärkkäinen, Pauliina and Salonen, Johanna and Rönnholm, Gunilla and Korkeamäki, Hanna and Vihinen, Mauno and Kalkkinen, Nisse and Lohi, Olli}}, issn = {{1873-5835}}, keywords = {{Repressor Proteins: metabolism; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: metabolism; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: diagnosis; Nuclear Proteins: metabolism; Cell Nucleolus: metabolism; DNA-Binding Proteins: metabolism; Tumor Markers; Biological: metabolism}}, language = {{eng}}, number = {{2}}, pages = {{232--236}}, publisher = {{Elsevier}}, series = {{Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis}}, title = {{Nucleolar proteins with altered expression in leukemic cell lines.}}, url = {{http://dx.doi.org/10.1016/j.leukres.2011.06.038}}, doi = {{10.1016/j.leukres.2011.06.038}}, volume = {{36}}, year = {{2012}}, }