A Microdialysis probe coupled with a miniaturized thermal glucose sensor for in vivo monitoring
(1995) In Analytical Letters 28(13). p.2275-2286- Abstract
A miniaturized thermal flow injection analysis biosensor has been
coupled with a microdialysis probe for continuous subcutaneous glucose
monitoring. Thermal biosensors are based on the principle of measuring
the heat evolved during enzyme catalysed reactions. The system presented
here consists of a miniaturized thermal biosensor with a small column
containing coimmibolized glucose oxidase and catalase. The analysis
buffer passes through the column at a flow rate of 60μL/min via an 1μL
sample loop which is connected to a microdialysis probe.Invitro
results showed constant permeability of the probe and stability of the
biosensor response during 24 hours. The response time was 85 sec... (More)A miniaturized thermal flow injection analysis biosensor has been
coupled with a microdialysis probe for continuous subcutaneous glucose
monitoring. Thermal biosensors are based on the principle of measuring
the heat evolved during enzyme catalysed reactions. The system presented
here consists of a miniaturized thermal biosensor with a small column
containing coimmibolized glucose oxidase and catalase. The analysis
buffer passes through the column at a flow rate of 60μL/min via an 1μL
sample loop which is connected to a microdialysis probe.Invitro
results showed constant permeability of the probe and stability of the
biosensor response during 24 hours. The response time was 85 sec giving a
sample rate of 42 samples/hour.During a load experiment, the
(Less)
glucose profile in a healthy volunteer was followed both in the
subcutaneous tissue and blood using the microdialysis set-up proposed
and comparing to blood glucose analyser.
- author
- Amine, A. ; Digua, K. ; Xie, B. LU and Danielsson, B. LU
- organization
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Glucose Biosensor, In-Vivo Monitoring, Microdialysis, Thermal
- in
- Analytical Letters
- volume
- 28
- issue
- 13
- pages
- 12 pages
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:0028814787
- ISSN
- 0003-2719
- DOI
- 10.1080/00032719508000371
- language
- English
- LU publication?
- yes
- id
- 363ffe68-a159-4ee5-93d3-d6c4a95f610d
- date added to LUP
- 2021-10-27 15:51:56
- date last changed
- 2021-11-01 11:36:16
@article{363ffe68-a159-4ee5-93d3-d6c4a95f610d,
abstract = {{<p>A miniaturized thermal flow injection analysis biosensor has been <br>
coupled with a microdialysis probe for continuous subcutaneous glucose <br>
monitoring. Thermal biosensors are based on the principle of measuring <br>
the heat evolved during enzyme catalysed reactions. The system presented<br>
here consists of a miniaturized thermal biosensor with a small column <br>
containing coimmibolized glucose oxidase and catalase. The analysis <br>
buffer passes through the column at a flow rate of 60μL/min via an 1μL <br>
sample loop which is connected to a microdialysis probe.</p> <p>Invitro <br>
results showed constant permeability of the probe and stability of the <br>
biosensor response during 24 hours. The response time was 85 sec giving a<br>
sample rate of 42 samples/hour.</p> <p>During a load experiment, the <br>
glucose profile in a healthy volunteer was followed both in the <br>
subcutaneous tissue and blood using the microdialysis set-up proposed <br>
and comparing to blood glucose analyser.</p>}},
author = {{Amine, A. and Digua, K. and Xie, B. and Danielsson, B.}},
issn = {{0003-2719}},
keywords = {{Glucose Biosensor; In-Vivo Monitoring; Microdialysis; Thermal}},
language = {{eng}},
number = {{13}},
pages = {{2275--2286}},
publisher = {{Taylor & Francis}},
series = {{Analytical Letters}},
title = {{A Microdialysis probe coupled with a miniaturized thermal glucose sensor for in vivo monitoring}},
url = {{http://dx.doi.org/10.1080/00032719508000371}},
doi = {{10.1080/00032719508000371}},
volume = {{28}},
year = {{1995}},
}