Effects of n-3 polyunsaturated fatty acids on left ventricular function and coronary flow in children with type 1 diabetes mellitus
Aburawi, Elhadi H. ; Liuba, Petru LU ; Odermarsky, Michal LU
; Sjöblad, Sture
LU
and Pesonen, Erkki
LU
(2011)
ESC Congress, 2011
In European Heart Journal
32(Supplement 1).
p.860-861
- Abstract
- Purposes: It has earlier been suggested that dietary supplementation with N-3 Polyunsaturated Fatty Acids (n-3 PUFAs) could have beneficial effects on cardio- vascular system patients with type 1 diabetes mellitus (DM1). Whether the benefit also extends to coronary circulation has not been yet investigated.Methods: In a double-blind placebo controlled cross-over study, 33 children with DM1 duration of more than one year were randomly and equally assigned to either n-3 PUFAs (2 gm/day, Nycoplus® Omega-3) or placebo treatment for 4 weeks. Following a 4-week period recovery, the groups were crossovered with above treatments for another 4 weeks. Transthoracic Doppler echocardiography (TTDE) study was done on each visit; pre treatment, post... (More)
- Purposes: It has earlier been suggested that dietary supplementation with N-3 Polyunsaturated Fatty Acids (n-3 PUFAs) could have beneficial effects on cardio- vascular system patients with type 1 diabetes mellitus (DM1). Whether the benefit also extends to coronary circulation has not been yet investigated.Methods: In a double-blind placebo controlled cross-over study, 33 children with DM1 duration of more than one year were randomly and equally assigned to either n-3 PUFAs (2 gm/day, Nycoplus® Omega-3) or placebo treatment for 4 weeks. Following a 4-week period recovery, the groups were crossovered with above treatments for another 4 weeks. Transthoracic Doppler echocardiography (TTDE) study was done on each visit; pre treatment, post treatment with n-3 PU- FAs on one occasion and with placebo on another and after one month recovery to assess left ventricular function and flow in the left anterior descending coronary artery (LAD). All data are mean±SD.Results: Of 33 recruited children, 28 (85%) completed the study. n-3 PUFAs treatment was associated with increase in both mean cardiac index (CI; from 2.7±0.4 to 3.7±0.8 l/min/m2, p<0.0001) and left ventricular fractional shortening (FS; from 31±2.5 to 39±3%, p<0.0001). In placebo treated groups there were no significant changes in these parameters. Also N-3 PUFAs treatment was as- sociated to decrease of both LAD peak flow velocity (PFVd; from 96±17 to 68±12 cm/s, p<0.0001) and LADs CF (from 105±31 to 66±15 ml/min, p<0.0001). Stop- ping n-3 PUFAs treatment and after one month recovery led to decrease of CI from 3.7±0.8 to 2.6±0.5 l/min/m2, p<0.0001 and mean FS from 39±3 to 32±2, p<0.0001. Mean PFVd increased from 68±12 to 90±12 cm/s, p<0.0001 and CF from 66±15 to 108±30 ml/min, p<0.0001.Conclusions: In patients with DM1, basal coronary flow parameters are in- creased, which could contribute to reduced coronary flow reserve. Treatment with n-3 PUFAs increases the cardiac index and LV systolic function and reverses the increased basal coronary flow, thereby improving the circumstances for better coronary flow reserve. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/368defa1-39f8-4495-809d-e9b6ef7e8c74
- author
- Aburawi, Elhadi H.
; Liuba, Petru
LU
; Odermarsky, Michal
LU
; Sjöblad, Sture
LU
and Pesonen, Erkki
LU
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Heart Journal
- volume
- 32
- issue
- Supplement 1
- article number
- P4830
- pages
- 1 pages
- publisher
- Oxford University Press
- conference name
- ESC Congress, 2011
- conference location
- Paris, France
- conference dates
- 2011-08-27 - 2011-08-31
- ISSN
- 0195-668X
- DOI
- 10.1093/eurheartj/ehr324
- language
- Swedish
- LU publication?
- no
- id
- 368defa1-39f8-4495-809d-e9b6ef7e8c74
- date added to LUP
- 2018-02-03 11:43:22
- date last changed
- 2021-03-22 18:11:57
@misc{368defa1-39f8-4495-809d-e9b6ef7e8c74,
abstract = {{Purposes: It has earlier been suggested that dietary supplementation with N-3 Polyunsaturated Fatty Acids (n-3 PUFAs) could have beneficial effects on cardio- vascular system patients with type 1 diabetes mellitus (DM1). Whether the benefit also extends to coronary circulation has not been yet investigated.Methods: In a double-blind placebo controlled cross-over study, 33 children with DM1 duration of more than one year were randomly and equally assigned to either n-3 PUFAs (2 gm/day, Nycoplus® Omega-3) or placebo treatment for 4 weeks. Following a 4-week period recovery, the groups were crossovered with above treatments for another 4 weeks. Transthoracic Doppler echocardiography (TTDE) study was done on each visit; pre treatment, post treatment with n-3 PU- FAs on one occasion and with placebo on another and after one month recovery to assess left ventricular function and flow in the left anterior descending coronary artery (LAD). All data are mean±SD.Results: Of 33 recruited children, 28 (85%) completed the study. n-3 PUFAs treatment was associated with increase in both mean cardiac index (CI; from 2.7±0.4 to 3.7±0.8 l/min/m2, p<0.0001) and left ventricular fractional shortening (FS; from 31±2.5 to 39±3%, p<0.0001). In placebo treated groups there were no significant changes in these parameters. Also N-3 PUFAs treatment was as- sociated to decrease of both LAD peak flow velocity (PFVd; from 96±17 to 68±12 cm/s, p<0.0001) and LADs CF (from 105±31 to 66±15 ml/min, p<0.0001). Stop- ping n-3 PUFAs treatment and after one month recovery led to decrease of CI from 3.7±0.8 to 2.6±0.5 l/min/m2, p<0.0001 and mean FS from 39±3 to 32±2, p<0.0001. Mean PFVd increased from 68±12 to 90±12 cm/s, p<0.0001 and CF from 66±15 to 108±30 ml/min, p<0.0001.Conclusions: In patients with DM1, basal coronary flow parameters are in- creased, which could contribute to reduced coronary flow reserve. Treatment with n-3 PUFAs increases the cardiac index and LV systolic function and reverses the increased basal coronary flow, thereby improving the circumstances for better coronary flow reserve.}},
author = {{Aburawi, Elhadi H. and Liuba, Petru and Odermarsky, Michal and Sjöblad, Sture and Pesonen, Erkki}},
issn = {{0195-668X}},
language = {{swe}},
note = {{Conference Abstract}},
number = {{Supplement 1}},
pages = {{860--861}},
publisher = {{Oxford University Press}},
series = {{European Heart Journal}},
title = {{Effects of n-3 polyunsaturated fatty acids on left ventricular function and coronary flow in children with type 1 diabetes mellitus}},
url = {{http://dx.doi.org/10.1093/eurheartj/ehr324}},
doi = {{10.1093/eurheartj/ehr324}},
volume = {{32}},
year = {{2011}},
}