Cardiovascular function in children born very preterm after intrauterine growth restriction with severely abnormal umbilical artery blood flow.
Morsing, Eva LU ; Liuba, Petru LU ; Fellman, Vineta LU
; Marsal, Karel
LU
and Brodszki, Jana
LU
(2014)
In European Journal of Preventive Cardiology
21(10).
p.1257-1266
- Abstract
- AIMS: Low birthweight has been linked to increased cardiovascular risk in adulthood. We evaluated the effect on cardiovascular outcome of intrauterine growth restriction (IUGR) with abnormal fetal blood flow in children born very preterm. METHODS: Blood pressure, cardiac function and size, diameters, distensibility, and stiffness of the abdominal aorta, carotid, and popliteal arteries, and endothelial function were assessed non-invasively in 7-year-old children (n = 32) born very preterm with IUGR, with birthweight (median, range) 650 g (395-976 g) and gestational age 27 weeks (24-29 weeks). In addition, intima-media thickness was measured in the carotid artery. Controls were matched for gender and age and had birthweight... (More)
- AIMS: Low birthweight has been linked to increased cardiovascular risk in adulthood. We evaluated the effect on cardiovascular outcome of intrauterine growth restriction (IUGR) with abnormal fetal blood flow in children born very preterm. METHODS: Blood pressure, cardiac function and size, diameters, distensibility, and stiffness of the abdominal aorta, carotid, and popliteal arteries, and endothelial function were assessed non-invasively in 7-year-old children (n = 32) born very preterm with IUGR, with birthweight (median, range) 650 g (395-976 g) and gestational age 27 weeks (24-29 weeks). In addition, intima-media thickness was measured in the carotid artery. Controls were matched for gender and age and had birthweight appropriate-for-gestational-age (AGA). The study included 32 preterm-AGA children with birthweight 1010 g (660-1790) g and 32 term-AGA children with birthweight 3530 g (3000-4390) g. RESULTS: Preterm-IUGR children had lower microvascular response to acetylcholine, lower aortic stiffness, and higher distensibility compared with the preterm-AGA group (p = 0.019, p = 0.001, and p < 0.001, respectively) and lower carotid intima-media thickness compared with the term-AGA group (p = 0.047). The highest aortic β and lowest distensibility were found in the preterm-AGA group. Height-adjusted systolic blood pressure was higher in the preterm groups than in the term-AGA group (p = 0.018). Cardiac function and size did not differ between the groups. CONCLUSION: IUGR and preterm birth appear to be associated with structural changes in the arterial wall, whereas preterm birth seems to be associated with higher blood pressure. Using conventional echocardiography, we observed no effect of IUGR on cardiac size and function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3733405
- author
- Morsing, Eva
LU
; Liuba, Petru
LU
; Fellman, Vineta
LU
; Marsal, Karel
LU
and Brodszki, Jana
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Preventive Cardiology
- volume
- 21
- issue
- 10
- pages
- 1257 - 1266
- publisher
- Oxford University Press
- external identifiers
-
- pmid:23613223
- wos:000342818000008
- scopus:84907502042
- ISSN
- 2047-4881
- DOI
- 10.1177/2047487313486044
- language
- English
- LU publication?
- yes
- id
- c153b850-bbaf-44f3-b01d-d86ee3986d9c (old id 3733405)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23613223?dopt=Abstract
- date added to LUP
- 2016-04-01 10:47:04
- date last changed
- 2022-02-02 20:55:30
@article{c153b850-bbaf-44f3-b01d-d86ee3986d9c,
abstract = {{AIMS: Low birthweight has been linked to increased cardiovascular risk in adulthood. We evaluated the effect on cardiovascular outcome of intrauterine growth restriction (IUGR) with abnormal fetal blood flow in children born very preterm. METHODS: Blood pressure, cardiac function and size, diameters, distensibility, and stiffness of the abdominal aorta, carotid, and popliteal arteries, and endothelial function were assessed non-invasively in 7-year-old children (n = 32) born very preterm with IUGR, with birthweight (median, range) 650 g (395-976 g) and gestational age 27 weeks (24-29 weeks). In addition, intima-media thickness was measured in the carotid artery. Controls were matched for gender and age and had birthweight appropriate-for-gestational-age (AGA). The study included 32 preterm-AGA children with birthweight 1010 g (660-1790) g and 32 term-AGA children with birthweight 3530 g (3000-4390) g. RESULTS: Preterm-IUGR children had lower microvascular response to acetylcholine, lower aortic stiffness, and higher distensibility compared with the preterm-AGA group (p = 0.019, p = 0.001, and p < 0.001, respectively) and lower carotid intima-media thickness compared with the term-AGA group (p = 0.047). The highest aortic β and lowest distensibility were found in the preterm-AGA group. Height-adjusted systolic blood pressure was higher in the preterm groups than in the term-AGA group (p = 0.018). Cardiac function and size did not differ between the groups. CONCLUSION: IUGR and preterm birth appear to be associated with structural changes in the arterial wall, whereas preterm birth seems to be associated with higher blood pressure. Using conventional echocardiography, we observed no effect of IUGR on cardiac size and function.}},
author = {{Morsing, Eva and Liuba, Petru and Fellman, Vineta and Marsal, Karel and Brodszki, Jana}},
issn = {{2047-4881}},
language = {{eng}},
number = {{10}},
pages = {{1257--1266}},
publisher = {{Oxford University Press}},
series = {{European Journal of Preventive Cardiology}},
title = {{Cardiovascular function in children born very preterm after intrauterine growth restriction with severely abnormal umbilical artery blood flow.}},
url = {{http://dx.doi.org/10.1177/2047487313486044}},
doi = {{10.1177/2047487313486044}},
volume = {{21}},
year = {{2014}},
}