Network of interactions among pair-rule genes regulating paired expression during primordial segmentation of Drosophila
Baumgartner, Stefan LU
and Noll, Markus
(1990)
In Mechanisms of Development
33(1).
p.1-18
- Abstract
A model of the trans-regulation of the Drosophila pair-rule segmentation gene, paired (prd), has been derived from the observed alterations in the distribution of prd transcripts during early embryogenesis in single and double pair-rule mutants. Important aspects of the model include the following features and implications: (i) The regulation of prd is subject to a regulatory hierarchy among pair-rule genes. In particular, it shows that prd is at the bottom of this hierarchy, mediating the transition from pair-rule to segment-polarity genes. The transition of the early 'pair-rule' to the 'segment-polarity' pattern of prd expression is regulated by the secondary pair-rule genes opa and odd. The model predicts the distributions of... (More)
A model of the trans-regulation of the Drosophila pair-rule segmentation gene, paired (prd), has been derived from the observed alterations in the distribution of prd transcripts during early embryogenesis in single and double pair-rule mutants. Important aspects of the model include the following features and implications: (i) The regulation of prd is subject to a regulatory hierarchy among pair-rule genes. In particular, it shows that prd is at the bottom of this hierarchy, mediating the transition from pair-rule to segment-polarity genes. The transition of the early 'pair-rule' to the 'segment-polarity' pattern of prd expression is regulated by the secondary pair-rule genes opa and odd. The model predicts the distributions of pair-rule gene products regulating prd at late syncytial blastoderm, e.g., that of opa. (ii) The initial activation of prd is independent of pair-rule genes. (iii) The regulation of prd is combinatorial and hence probably cooperative. Combination of one pair-rule gene product with different pair-rule gene proteins may lead to opposite regulatory effects on prd. Furthermore, we discuss a two-step conversion of the initial analogue specification of position along the anteroposterior axis into a digital code specified by combinations of active segment-polarity and homeotic genes.
(Less)
- author
- Baumgartner, Stefan
LU
and Noll, Markus
- publishing date
- 1990-01-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Digital positional code, Drosophila segmentation, Pair-rule gene hierarchy, Paired gene regulation
- in
- Mechanisms of Development
- volume
- 33
- issue
- 1
- pages
- 1 - 18
- publisher
- Elsevier
- external identifiers
-
- scopus:0025663641
- pmid:1982920
- ISSN
- 0925-4773
- DOI
- 10.1016/0925-4773(90)90130-E
- language
- English
- LU publication?
- no
- id
- 37be151b-2f13-44a3-98a7-d5de231de1da
- date added to LUP
- 2019-05-21 14:10:31
- date last changed
- 2024-01-01 05:55:34
@article{37be151b-2f13-44a3-98a7-d5de231de1da,
abstract = {{<p>A model of the trans-regulation of the Drosophila pair-rule segmentation gene, paired (prd), has been derived from the observed alterations in the distribution of prd transcripts during early embryogenesis in single and double pair-rule mutants. Important aspects of the model include the following features and implications: (i) The regulation of prd is subject to a regulatory hierarchy among pair-rule genes. In particular, it shows that prd is at the bottom of this hierarchy, mediating the transition from pair-rule to segment-polarity genes. The transition of the early 'pair-rule' to the 'segment-polarity' pattern of prd expression is regulated by the secondary pair-rule genes opa and odd. The model predicts the distributions of pair-rule gene products regulating prd at late syncytial blastoderm, e.g., that of opa. (ii) The initial activation of prd is independent of pair-rule genes. (iii) The regulation of prd is combinatorial and hence probably cooperative. Combination of one pair-rule gene product with different pair-rule gene proteins may lead to opposite regulatory effects on prd. Furthermore, we discuss a two-step conversion of the initial analogue specification of position along the anteroposterior axis into a digital code specified by combinations of active segment-polarity and homeotic genes.</p>}},
author = {{Baumgartner, Stefan and Noll, Markus}},
issn = {{0925-4773}},
keywords = {{Digital positional code; Drosophila segmentation; Pair-rule gene hierarchy; Paired gene regulation}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{1--18}},
publisher = {{Elsevier}},
series = {{Mechanisms of Development}},
title = {{Network of interactions among pair-rule genes regulating paired expression during primordial segmentation of Drosophila}},
url = {{http://dx.doi.org/10.1016/0925-4773(90)90130-E}},
doi = {{10.1016/0925-4773(90)90130-E}},
volume = {{33}},
year = {{1990}},
}