The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate
(1985) In Scandinavian Journal of Clinical & Laboratory Investigation 45(2). p.97-101- Abstract
- The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for retinol-binding protein (r = 0.39). The calculated values of the glomerular elimination rate for creatinine and cystatin C were normally distributed in contrast to those for beta 2-microglobulin. The calculated glomerular... (More)
- The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for retinol-binding protein (r = 0.39). The calculated values of the glomerular elimination rate for creatinine and cystatin C were normally distributed in contrast to those for beta 2-microglobulin. The calculated glomerular elimination rate of cystatin C was not correlated to age, sex, type of disorder or disease activity. The results demonstrate that the serum level of cystatin C is a better measure of the glomerular filtration rate than the serum level of beta 2-microglobulin. (Less)
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https://lup.lub.lu.se/record/37eb603a-a152-43e4-a6b4-242b4147e05e
- author
- Simonsen, Ole LU ; Grubb, Anders LU and Thysell, Hans LU
- organization
- publishing date
- 1985
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 45
- issue
- 2
- pages
- 97 - 101
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:3923607
- scopus:0021964955
- ISSN
- 1502-7686
- DOI
- 10.3109/00365518509160980
- language
- English
- LU publication?
- yes
- id
- 37eb603a-a152-43e4-a6b4-242b4147e05e
- date added to LUP
- 2018-11-16 16:35:39
- date last changed
- 2021-11-08 04:00:14
@article{37eb603a-a152-43e4-a6b4-242b4147e05e, abstract = {{The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for retinol-binding protein (r = 0.39). The calculated values of the glomerular elimination rate for creatinine and cystatin C were normally distributed in contrast to those for beta 2-microglobulin. The calculated glomerular elimination rate of cystatin C was not correlated to age, sex, type of disorder or disease activity. The results demonstrate that the serum level of cystatin C is a better measure of the glomerular filtration rate than the serum level of beta 2-microglobulin.}}, author = {{Simonsen, Ole and Grubb, Anders and Thysell, Hans}}, issn = {{1502-7686}}, language = {{eng}}, number = {{2}}, pages = {{97--101}}, publisher = {{Informa Healthcare}}, series = {{Scandinavian Journal of Clinical & Laboratory Investigation}}, title = {{The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate}}, url = {{http://dx.doi.org/10.3109/00365518509160980}}, doi = {{10.3109/00365518509160980}}, volume = {{45}}, year = {{1985}}, }